Abstract:
:1H NMR spin-echo spectroscopy has been used to study the metabolism of exogenous compounds in human erythrocytes. The non-invasive nature of the technique and the continuous monitoring makes it ideal to investigate both the conversion of substrates and the occurrence and the nature of the products. Hydrolysis rates may be determined and the hydrolysis of alkyl, vinyl, and aryl acetates are shown to be due to A-esterase activity. The conversion products are normally observed, but in the case of dimethyl phthalate and methyl acetate only part of the methanol is found. An interesting case is the hydrolysis of vinyl acetate and the consecutive conversion of the vinyl alcohol to acetaldehyde (hydrate). Coupling of glutathione to a variety of vinyl derivatives is also observed. Oxidation of acetaldehyde can also be followed. Styrene and 5-chloro-2-methylaniline are slowly converted in what is believed to be oxidation reactions. Changes in 1H chemical shifts are observed for a number of compounds upon uptake into human erythrocytes, a shift that is suggested to be due to binding to haemoglobin.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Skibsted U,Hansen PEdoi
10.1002/nbm.1940030603subject
Has Abstractpub_date
1990-12-01 00:00:00pages
248-58issue
6eissn
0952-3480issn
1099-1492journal_volume
3pub_type
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journal_title:NMR in biomedicine
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abstract::Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting ante...
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journal_title:NMR in biomedicine
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abstract::Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...
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pub_type: 杂志文章
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abstract::The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
abstract::Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techn...
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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abstract::The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.
更新日期:2000-06-01 00:00:00
abstract::More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were rai...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:1993-11-01 00:00:00
abstract::Cerebral ischemia provokes tissue damage by two major patho-physiological mechanisms. Direct cell necrosis is induced by diminished access of neurons and glia to essential nutrients such as glucose and oxygen leading to energy failure. A second factor of cellular loss is related to the activation of immune-competent c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.770
更新日期:2002-06-01 00:00:00
abstract::The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3308
更新日期:2015-06-01 00:00:00
abstract::An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpola...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3690
更新日期:2017-05-01 00:00:00
abstract::The significance of NMR water diffusion measurements performed at short diffusion times (< 10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070703
更新日期:1994-11-01 00:00:00
abstract::The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3877
更新日期:2018-03-01 00:00:00
abstract::This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5 cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1595
更新日期:2011-04-01 00:00:00
abstract::There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2814
更新日期:2013-01-01 00:00:00
abstract::The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3358
更新日期:2015-09-01 00:00:00
abstract::Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070503
更新日期:1994-08-01 00:00:00
abstract::We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940050109
更新日期:1992-01-01 00:00:00
abstract::Vessel size index (VSI), a parameter related to the distribution of vessel diameters, may be estimated using two MRI approaches: (i) dynamic susceptibility contrast (DSC) MRI following the injection of a bolus of Gd-chelate. This technique is routinely applied in the clinic to assess intracranial tissue perfusion in p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1734
更新日期:2012-02-01 00:00:00
abstract::In MR elastography, it is common to use an elastic model for the tissue's response in order to interpret the results properly. More complex models, such as viscoelastic, fractional viscoelastic, poroelastic, or poroviscoelastic ones, are also used. These models appear at first sight to be very different, but here it i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3854
更新日期:2018-10-01 00:00:00
abstract::133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.909
更新日期:2005-04-01 00:00:00
abstract::In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4298
更新日期:2020-07-01 00:00:00
abstract::Management of brain tumours in children would benefit from improved non-invasive diagnosis, characterisation and prognostic biomarkers. Metabolite profiles derived from in-vivo MRS have been shown to provide such information. Studies indicate that using optimum a priori information on metabolite contents in the constr...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1432
更新日期:2010-01-01 00:00:00
abstract::This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020102
更新日期:1989-06-01 00:00:00
abstract::Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.3778
更新日期:2019-04-01 00:00:00
abstract::Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examin...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940050516
更新日期:1992-09-01 00:00:00
abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940010207
更新日期:1988-04-01 00:00:00