1H NMR spin-echo spectroscopy of human erythrocytes. Transformation of exogenous compounds.

Abstract:

:1H NMR spin-echo spectroscopy has been used to study the metabolism of exogenous compounds in human erythrocytes. The non-invasive nature of the technique and the continuous monitoring makes it ideal to investigate both the conversion of substrates and the occurrence and the nature of the products. Hydrolysis rates may be determined and the hydrolysis of alkyl, vinyl, and aryl acetates are shown to be due to A-esterase activity. The conversion products are normally observed, but in the case of dimethyl phthalate and methyl acetate only part of the methanol is found. An interesting case is the hydrolysis of vinyl acetate and the consecutive conversion of the vinyl alcohol to acetaldehyde (hydrate). Coupling of glutathione to a variety of vinyl derivatives is also observed. Oxidation of acetaldehyde can also be followed. Styrene and 5-chloro-2-methylaniline are slowly converted in what is believed to be oxidation reactions. Changes in 1H chemical shifts are observed for a number of compounds upon uptake into human erythrocytes, a shift that is suggested to be due to binding to haemoglobin.

journal_name

NMR Biomed

journal_title

NMR in biomedicine

authors

Skibsted U,Hansen PE

doi

10.1002/nbm.1940030603

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

248-58

issue

6

eissn

0952-3480

issn

1099-1492

journal_volume

3

pub_type

杂志文章
  • In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: clinical applications to dietary therapy.

    abstract::Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...

    journal_title:NMR in biomedicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/nbm.824

    authors: Hwang JH,Bluml S,Leaf A,Ross BD

    更新日期:2003-05-01 00:00:00

  • Resonant inductive decoupling (RID) for transceiver arrays to compensate for both reactive and resistive components of the mutual impedance.

    abstract::Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting ante...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.2989

    authors: Avdievich NI,Pan JW,Hetherington HP

    更新日期:2013-11-01 00:00:00

  • A multi-Gaussian model for apparent diffusion coefficient histogram analysis of Wilms' tumour subtype and response to chemotherapy.

    abstract::Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

    journal_title:NMR in biomedicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/nbm.3337

    authors: Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

    更新日期:2015-08-01 00:00:00

  • Glioma grading using apparent diffusion coefficient map: application of histogram analysis based on automatic segmentation.

    abstract::The accurate diagnosis of glioma subtypes is critical for appropriate treatment, but conventional histopathologic diagnosis often exhibits significant intra-observer variability and sampling error. The aim of this study was to investigate whether histogram analysis using an automatically segmented region of interest (...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3153

    authors: Lee J,Choi SH,Kim JH,Sohn CH,Lee S,Jeong J

    更新日期:2014-09-01 00:00:00

  • High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid.

    abstract::Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/1099-1492(200008)13:5<297::aid-nbm648>3.0.

    authors: Boss EA,Moolenaar SH,Massuger LF,Boonstra H,Engelke UF,de Jong JG,Wevers RA

    更新日期:2000-08-01 00:00:00

  • Detection of bioradicals by in vivo L-band electron spin resonance spectrometry.

    abstract::The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.898

    authors: Fujii H,Berliner LJ

    更新日期:2004-08-01 00:00:00

  • Electric properties tomography: Biochemical, physical and technical background, evaluation and clinical applications.

    abstract::Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techn...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.3729

    authors: Katscher U,van den Berg CAT

    更新日期:2017-08-01 00:00:00

  • The influence of obesity on cerebral blood flow in young adults using arterial spin labeling MRI.

    abstract::Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.4375

    authors: Peng SL,Chen CM

    更新日期:2020-10-01 00:00:00

  • Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging.

    abstract::The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3885

    authors: Liu YJ,Lee YH,Chang HC,Chiu HC,Chiu TW,Hsu K,Pen CM,Hsu HH,Juan CJ

    更新日期:2018-03-01 00:00:00

  • NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold.

    abstract::One of the major goals of hyperpolarized-gas MR imaging has been to obtain (129)Xe dissolved-phase images in humans. Since the dissolved-phase signal is much weaker than the gas-phase signal, highly optimized MR pulse sequences are required to obtain adequate images during a single breath-hold. In particular, a solid ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.

    authors: Ruppert K,Brookeman JR,Hagspiel KD,Driehuys B,Mugler JP 3rd

    更新日期:2000-06-01 00:00:00

  • In vivo 31P MRS of experimental tumours.

    abstract::More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were rai...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.1940060602

    authors: de Certaines JD,Larsen VA,Podo F,Carpinelli G,Briot O,Henriksen O

    更新日期:1993-11-01 00:00:00

  • In-vivo visualization of phagocytotic cells in rat brains after transient ischemia by USPIO.

    abstract::Cerebral ischemia provokes tissue damage by two major patho-physiological mechanisms. Direct cell necrosis is induced by diminished access of neurons and glia to essential nutrients such as glucose and oxygen leading to energy failure. A second factor of cellular loss is related to the activation of immune-competent c...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.770

    authors: Rausch M,Baumann D,Neubacher U,Rudin M

    更新日期:2002-06-01 00:00:00

  • Interventional MRI-guided local delivery of agents into swine bile duct walls using MR-compatible needle-integrated balloon catheter system.

    abstract::The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3308

    authors: Zhang F,Bai Z,Shi Y,Wang J,Li Y,Yang X

    更新日期:2015-06-01 00:00:00

  • An indirect method for in vivo T2 mapping of [1-13 C] pyruvate using hyperpolarized 13 C CSI.

    abstract::An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpola...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3690

    authors: Joe E,Lee H,Lee J,Yang S,Choi YS,Wang E,Song HT,Kim DH

    更新日期:2017-05-01 00:00:00

  • Health and infarcted brain tissues studied at short diffusion times: the origins of apparent restriction and the reduction in apparent diffusion coefficient.

    abstract::The significance of NMR water diffusion measurements performed at short diffusion times (< 10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramat...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940070703

    authors: Norris DG,Niendorf T,Leibfritz D

    更新日期:1994-11-01 00:00:00

  • Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod.

    abstract::The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3877

    authors: Ziser L,Meyer-Schell N,Kurniawan ND,Sullivan R,Reutens D,Chen M,Vegh V

    更新日期:2018-03-01 00:00:00

  • Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS.

    abstract::This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5  cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1595

    authors: Chen JH,Mehta RS,Baek HM,Nie K,Liu H,Lin MQ,Yu HJ,Nalcioglu O,Su MY

    更新日期:2011-04-01 00:00:00

  • NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential.

    abstract::There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.2814

    authors: Pudakalakatti SM,Uppangala S,D'Souza F,Kalthur G,Kumar P,Adiga SK,Atreya HS

    更新日期:2013-01-01 00:00:00

  • A statistical clustering approach to discriminating perfusion from conduit vessel signal contributions in a pulmonary ASL MR image.

    abstract::The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3358

    authors: Walker SC,Asadi AK,Hopkins SR,Buxton RB,Prisk GK

    更新日期:2015-09-01 00:00:00

  • 13C NMR kinetic studies of the rapid stimulation of glucose metabolism by estrogen in immature rat uterus.

    abstract::Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940070503

    authors: Shinkarenko L,Kaye AM,Degani H

    更新日期:1994-08-01 00:00:00

  • Brain metabolism and blood flow in acute cerebral hypoxia studied by NMR spectroscopy and hydrogen clearance.

    abstract::We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940050109

    authors: Allen K,Busza AL,Crockard HA,Gadian DG

    更新日期:1992-01-01 00:00:00

  • Vessel size index measurements in a rat model of glioma: comparison of the dynamic (Gd) and steady-state (iron-oxide) susceptibility contrast MRI approaches.

    abstract::Vessel size index (VSI), a parameter related to the distribution of vessel diameters, may be estimated using two MRI approaches: (i) dynamic susceptibility contrast (DSC) MRI following the injection of a bolus of Gd-chelate. This technique is routinely applied in the clinic to assess intracranial tissue perfusion in p...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1734

    authors: Pannetier N,Lemasson B,Christen T,Tachrount M,Troprès I,Farion R,Segebarth C,Rémy C,Barbier EL

    更新日期:2012-02-01 00:00:00

  • Spring-damper equivalents of the fractional, poroelastic, and poroviscoelastic models for elastography.

    abstract::In MR elastography, it is common to use an elastic model for the tissue's response in order to interpret the results properly. More complex models, such as viscoelastic, fractional viscoelastic, poroelastic, or poroviscoelastic ones, are also used. These models appear at first sight to be very different, but here it i...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3854

    authors: Holm S

    更新日期:2018-10-01 00:00:00

  • Biomedical applications of 133Cs NMR.

    abstract::133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.909

    authors: Goodman J,Neil JJ,Ackerman JJ

    更新日期:2005-04-01 00:00:00

  • Longitudinal assessment of tissue properties and cardiac diffusion metrics of the ex vivo porcine heart at 7 T: Impact of continuous tissue fixation using formalin.

    abstract::In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.4298

    authors: Lohr D,Terekhov M,Veit F,Schreiber LM

    更新日期:2020-07-01 00:00:00

  • Non-invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using in-vivo 1H MRS at 1.5 tesla confirmed by ex-vivo high-resolution magic-angle spinning NMR.

    abstract::Management of brain tumours in children would benefit from improved non-invasive diagnosis, characterisation and prognostic biomarkers. Metabolite profiles derived from in-vivo MRS have been shown to provide such information. Studies indicate that using optimum a priori information on metabolite contents in the constr...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1432

    authors: Davies NP,Wilson M,Natarajan K,Sun Y,MacPherson L,Brundler MA,Arvanitis TN,Grundy RG,Peet AC

    更新日期:2010-01-01 00:00:00

  • An NMR assessment of the rheological properties of blood and its constituents: a review.

    abstract::This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.1940020102

    authors: Berling C,Hall LD

    更新日期:1989-06-01 00:00:00

  • A review of diffusion MRI of typical white matter development from early childhood to young adulthood.

    abstract::Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.3778

    authors: Lebel C,Treit S,Beaulieu C

    更新日期:2019-04-01 00:00:00

  • Measurement of tumor blood flow by deuterium NMR and the effects of modifiers.

    abstract::Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examin...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.1940050516

    authors: Evelhoch JL

    更新日期:1992-09-01 00:00:00

  • pH and compartmentation of isolated perfused rat liver studied by 31P and 19F NMR.

    abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940010207

    authors: Thoma WJ,Uğurbil K

    更新日期:1988-04-01 00:00:00