Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.

abstract：:We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patient...

journal_title：NMR in biomedicine

authors： Menze BH,Lichy MP,Bachert P,Kelm BM,Schlemmer HP,Hamprecht FA

更新日期：2006-08-01 00:00:00

abstract：:In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid comp...

journal_title：NMR in biomedicine

authors： Mohajeri S,Ijare OB,Bezabeh T,King SB,Thomas MA,Minuk G,Lipschitz J,Kirkpatrick I,Smith M,Smith IC

更新日期：2014-10-01 00:00:00

abstract：:An MR thermometry method is proposed for measuring in vivo small temperature changes engendered by external RF heat sources. The method relies on reproducible and stable respiration and therefore currently applies to ventilated animals whose breathing is carefully controlled. It first consists in characterizing the st...

journal_title：NMR in biomedicine

authors： Boulant N,Bottlaender M,Uhrig L,Giacomini E,Luong M,Amadon A,Massire A,Larrat B,Vignaud A

更新日期：2015-01-01 00:00:00

abstract：:Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...

journal_title：NMR in biomedicine

authors： Sun H,Seres P,Wilman AH

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

journal_title：NMR in biomedicine

authors： Zhang J,Kim SG

更新日期：2019-11-01 00:00:00

abstract：:Phosphorus MRSI (31 P-MRSI) using a spiral-trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunte...

journal_title：NMR in biomedicine

authors： Valkovič L,Chmelík M,Meyerspeer M,Gagoski B,Rodgers CT,Krššák M,Andronesi OC,Trattnig S,Bogner W

更新日期：2016-12-01 00:00:00

abstract：:An optimized semi-LASER sequence that is capable of acquiring artefact-free data with an echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations were performed to determine the optimal TEs that minimize the expected Cramér-Rao lower bound (CRLB) as proxy for quantification accuracy of...

journal_title：NMR in biomedicine

authors： Landheer K,Gajdošík M,Juchem C

更新日期：2020-09-01 00:00:00

abstract：:A quantitative magnetization transfer (qMT) technique was employed to quantify the ratio of the sizes of the bound and free water proton pools in ex vivo mouse brains. The goal was to determine the pool size ratio sensitivity to myelin. Fixed brains from both shiverer mice and control littermates were imaged. The pool...

journal_title：NMR in biomedicine

authors： Ou X,Sun SW,Liang HF,Song SK,Gochberg DF

更新日期：2009-06-01 00:00:00

abstract：:The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...

journal_title：NMR in biomedicine

authors： Snaar JE,Teeuwisse WM,Versluis MJ,van Buchem MA,Kan HE,Smith NB,Webb AG

更新日期：2011-08-01 00:00:00

abstract：:13C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1-(13)C) glucose and/or (1-(13)C) acetate were administered orally or by intravenous infusion. (13)C spectra of diagnostic quality were acquired in more than 10...

journal_title：NMR in biomedicine

authors： Ross B,Lin A,Harris K,Bhattacharya P,Schweinsburg B

更新日期：2003-10-01 00:00:00

abstract：:The potential use of 13C multilabeled substrates has been studied in biological applications using in vivo and in vitro proton and 13C NMR spectroscopy. In 13C NMR spectroscopy, multilabeled compounds allow the simultaneous observation of several nuclei or increase distinctly the signal to noise ratio due to a higher ...

journal_title：NMR in biomedicine

authors： Künnecke B,Cerdan S

更新日期：1989-12-01 00:00:00

abstract：:Central obesity is the hallmark of a number of non-inheritable disorders. The advent of imaging techniques such as MRI has allowed for a fast and accurate assessment of body fat content and distribution. However, image analysis continues to be one of the major obstacles to the use of MRI in large-scale studies. In thi...

journal_title：NMR in biomedicine

authors： Borga M,Thomas EL,Romu T,Rosander J,Fitzpatrick J,Dahlqvist Leinhard O,Bell JD

更新日期：2015-12-01 00:00:00

abstract：:The leakage of metabolites from frozen and thawed tissue biopsies was measured semi-quantitatively by high-field (8.5 T) proton MRS. Human prostate and rat brain tissue specimens, frozen within 1 min of collection, lost significant and variable amounts of diagnostic metabolites immediately upon thawing. For prostate t...

journal_title：NMR in biomedicine

authors： Bourne R,Dzendrowskyj T,Mountford C

更新日期：2003-04-01 00:00:00

abstract：:MR spectroscopic imaging (MRSI) at ultra-high field (≥7 T) benefits from improved sensitivity that allows the detection of low-concentration metabolites in the brain. However, optimized acquisition techniques are required to overcome inherent limitations of MRSI at ultra-high field. This work describes an optimized me...

journal_title：NMR in biomedicine

authors： Coello E,Noeske R,Burns BL,Gordon JW,Jakary A,Menze B,Haase A,Larson PEZ,Li Y,Schulte RF

更新日期：2018-11-01 00:00:00

abstract：:(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...

journal_title：NMR in biomedicine

authors： Bakermans AJ,Abdurrachim D,van Nierop BJ,Koeman A,van der Kroon I,Baartscheer A,Schumacher CA,Strijkers GJ,Houten SM,Zuurbier CJ,Nicolay K,Prompers JJ

更新日期：2015-10-01 00:00:00

abstract：:This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...

journal_title：NMR in biomedicine

authors： Berling C,Hall LD

更新日期：1989-06-01 00:00:00

abstract：:Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...

journal_title：NMR in biomedicine

authors： Lipnick S,Liu X,Sayre J,Bassett LW,Debruhl N,Thomas MA

更新日期：2010-10-01 00:00:00

abstract：:A simple technique permitting long term 31P magnetic resonance spectroscopy of cultured mammalian cells is described. Cells are encapsulated in calcium alginate gels and perfused with a new phosphate-fre medium designed for maintenance of high cell viability. Intracellular pH and beta-NTP/Pi ratios, studied in three c...

journal_title：NMR in biomedicine

authors： Narayan KS,Moress EA,Chatham JC,Barker PB

更新日期：1990-02-01 00:00:00

abstract：:Hyperpolarised (HP) (13)C NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding of enzyme kinetics. The increased conversion of pyruvate to lactate in cancer cells has been well st...

journal_title：NMR in biomedicine

authors： Breukels V,Jansen KC,van Heijster FH,Capozzi A,van Bentum PJ,Schalken JA,Comment A,Scheenen TW

更新日期：2015-08-01 00:00:00

abstract：:Cerebral ischemia provokes tissue damage by two major patho-physiological mechanisms. Direct cell necrosis is induced by diminished access of neurons and glia to essential nutrients such as glucose and oxygen leading to energy failure. A second factor of cellular loss is related to the activation of immune-competent c...

journal_title：NMR in biomedicine

authors： Rausch M,Baumann D,Neubacher U,Rudin M

更新日期：2002-06-01 00:00:00

abstract：:In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...

journal_title：NMR in biomedicine

authors： Schad LR

更新日期：2001-11-01 00:00:00

abstract：:Studies of cholesteryl ester transfer protein (CETP) function in lipoprotein mixtures pose many difficulties by conventional biochemical methods. For instance, studies on the effects of CETP on the composition of apolipoprotein B containing lipoproteins (very low and low density lipoproteins) in lipoprotein mixtures a...

journal_title：NMR in biomedicine

authors： Korhonen A,Ala-Korpela M,Liinamaa MJ,Jokisaari J,Kesäniemi YA,Savolainen MJ

更新日期：1997-10-01 00:00:00

abstract：:Given the importance of genetically modified mice in studies of mammalian brain development and human congenital brain diseases, MRI has the potential to provide an efficient in vivo approach for analyzing mutant phenotypes in the early postnatal mouse brain. The combination of reduced tissue contrast at the high magn...

journal_title：NMR in biomedicine

authors： Wadghiri YZ,Blind JA,Duan X,Moreno C,Yu X,Joyner AL,Turnbull DH

更新日期：2004-12-01 00:00:00

abstract：:Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The magnetic resonance signal enhancement provided by spin hyperpolarization allows the metabolism of substrates labeled with carbon-13 t...

journal_title：NMR in biomedicine

authors： Yoshihara HAI,Bastiaansen JAM,Karlsson M,Lerche MH,Comment A,Schwitter J

更新日期：2020-03-01 00:00:00

abstract：:Phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) has gained much interest in schizophrenia research in recent years since it allows the non-invasive measurement of high-energy phosphates and phospholipids in vivo. However, until now only differences in metabolite concentrations between certain brain areas of ...

journal_title：NMR in biomedicine

authors： Riehemann S,Volz HP,Wenda B,Hübner G,Rössger G,Rzanny R,Sauer H

更新日期：1999-12-01 00:00:00

abstract：:In this study the conjugated macromolecular ligand, diethylenetriaminepentaacetic acid (DTPA)-amide-dextran, was synthesized by attaching DTPA to the dextran macromolecule (M(r) approximately 6000) by a covalent amide bond. Subsequently, DTPA-amide-dextran was complexed with either of the two lanthanide metal ions dys...

journal_title：NMR in biomedicine

authors： Chu WJ,Elgavish GA

更新日期：1995-06-01 00:00:00

abstract：:In this work we introduce the concept of correlation chemical shift imaging (CCSI). Novel CCSI pulse sequences are demonstrated on clinical scanners for two-dimensional Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) imaging experiments. To date there has been limited progress reported towar...

journal_title：NMR in biomedicine

authors： Andronesi OC,Gagoski BA,Adalsteinsson E,Sorensen AG

更新日期：2012-02-01 00:00:00

abstract：:One of the hallmarks of diffusion NMR and MRI is its ability to utilize restricted diffusion to probe compartments much smaller than the excited volume or the MRI voxel, respectively, and to extract microstructural information from them. Single-pulsed field gradient (s-PFG) MR methodologies have been employed with gre...

journal_title：NMR in biomedicine

authors： Shemesh N,Ozarslan E,Komlosh ME,Basser PJ,Cohen Y

更新日期：2010-08-01 00:00:00

abstract：:Glucosamine (GlcN) modulates fluoropyrimidine metabolism and enhances cytotoxicity of 5-fluorouridine (FUrd), but not of 5-fluorouracil (FUra), in human tumor models. To elucidate the underlying metabolic differences between FUra and FUrd, by the use of 19F and 31P NMR spectroscopy we studied these drugs in multicell ...

journal_title：NMR in biomedicine

authors： Chen TB,Bajzer Z,Macura S,Vuk-Pavlovic S

更新日期：1999-05-01 00:00:00

abstract：:Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...

journal_title：NMR in biomedicine

authors： Baudelet C,Cron GO,Ansiaux R,Crokart N,DeWever J,Feron O,Gallez B

更新日期：2006-02-01 00:00:00