Multilabeled 13C substrates as probes in in vivo 13C and 1H NMR spectroscopy.

Abstract:

:The potential use of 13C multilabeled substrates has been studied in biological applications using in vivo and in vitro proton and 13C NMR spectroscopy. In 13C NMR spectroscopy, multilabeled compounds allow the simultaneous observation of several nuclei or increase distinctly the signal to noise ratio due to a higher degree of enrichment. Contiguous labeling of substrates leads to homonuclear 13C-13C spin couplings and provides a simple means to distinguish between endogenous stores of metabolites and metabolites derived from added substrates.

journal_name

NMR Biomed

journal_title

NMR in biomedicine

authors

Künnecke B,Cerdan S

doi

10.1002/nbm.1940020516

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

274-7

issue

5-6

eissn

0952-3480

issn

1099-1492

journal_volume

2

pub_type

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