Abstract:
:A quantitative magnetization transfer (qMT) technique was employed to quantify the ratio of the sizes of the bound and free water proton pools in ex vivo mouse brains. The goal was to determine the pool size ratio sensitivity to myelin. Fixed brains from both shiverer mice and control littermates were imaged. The pool size ratio in the corpus callosum of shiverer mice was substantially lower than that in the control mice, while there was no distinguishable difference in the pool size ratio in the gray matter. These results correlate with diffusion tensor imaging (DTI) derived radial diffusivity which previously was shown to reflect myelin integrity in this animal model. Histological study reveals the presence of myelin in control mice white matter and the absence of myelin in shiverer mice white matter, supporting the qMT and DTI results. Our findings support the view that qMT may be used for estimating myelin integrity.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Ou X,Sun SW,Liang HF,Song SK,Gochberg DFdoi
10.1002/nbm.1358subject
Has Abstractpub_date
2009-06-01 00:00:00pages
480-7issue
5eissn
0952-3480issn
1099-1492journal_volume
22pub_type
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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abstract::Modified gradient-echo MR techniques were applied to study the effects of inflow on functional brain imaging studies using visual and motor cortex stimulation. The results demonstrate that the large signal changes, seen in previously reported gradient-echo studies at 1.5-2.0 T, are dominated by direct inflow effects, ...
journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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更新日期:2004-06-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2009-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
abstract::The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-ha...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.2885
更新日期:2013-08-01 00:00:00
abstract::MRI detects changes in blood-oxygenation-level dependent (BOLD) contrast in tumors caused by tumor oxygenating agents. These changes can be used to guide the design of improved tumor oxygenating treatments (TOXs). The conventional approach to detection of BOLD effects assumes that the water resonance is a single, homo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.728
更新日期:2002-02-01 00:00:00
abstract::More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were rai...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940060602
更新日期:1993-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199912)12:8<483::aid-nbm58
更新日期:1999-12-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199701)10:1<13::aid-nbm443
更新日期:1997-01-01 00:00:00
abstract::Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1511
更新日期:2010-10-01 00:00:00
abstract::Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1556
更新日期:2011-01-01 00:00:00
abstract::The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.898
更新日期:2004-08-01 00:00:00
abstract::The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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abstract::31P Nuclear magnetic resonance spectroscopy has been used to investigate the combined effect of 70 mM ethanol administration and hypoxia on the energetic metabolism and cytosolic pH of the perfused liver isolated from naive, fasted or chronically ethanol-treated rats. Ethanol-treatment or fasting induce a similar 25% ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940030306
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1149
更新日期:2007-05-01 00:00:00
abstract::Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2021-01-21 00:00:00
abstract::Localization techniques are considered an indispensable part of the clinical spectroscopy examination. The results are often a marked improvement in diagnostic information (amplification), but because of the introduction of new artifacts and the more prolonged examination time, some of the undoubted advantage is lost ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020525
更新日期:1989-12-01 00:00:00
abstract::At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1754
更新日期:2012-02-01 00:00:00
abstract::The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3837
更新日期:2018-01-01 00:00:00
abstract::We propose a very high-resolution, three-dimensional (3D) gradient-echo technique with a twofold parallel imaging acceleration using a specialized occipital receiver coil at 3 T to perform functional MRI (fMRI) of the visual cortex. This configuration makes it possible to acquire 3D fMRI data within a timescale compat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1158
更新日期:2007-08-01 00:00:00
abstract::The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including py...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1039
更新日期:2006-06-01 00:00:00
abstract::An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...
journal_title:NMR in biomedicine
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doi:10.1002/nbm.1261
更新日期:2008-11-01 00:00:00