Effect of ethanol on hepatic energy metabolism and intracellular pH in chronically ethanol-treated rats. A 31P NMR study of normoxic or hypoxic perfused liver.

abstract：:The accuracy and precision of the quantification of metabolite concentrations in in vivo (1) H NMR spectroscopy are affected by linewidth and signal-to-noise ratio (SNR). To study the effect of both factors in in vivo (1) H NMR spectra acquired at ultrahigh field, a reference spectrum was generated by summing nine in ...

journal_title：NMR in biomedicine

authors： Hong ST,Pohmann R

更新日期：2013-01-01 00:00:00

abstract：:Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, wit...

journal_title：NMR in biomedicine

authors： Turnbull DH,Mori S

更新日期：2007-05-01 00:00:00

abstract：:The application of 31P MR spectroscopy in the characterization and treatment of malignant human extremity tumors is reviewed and placed in the perspective of results obtained in murine sarcomas. Despite the now widespread acquisition of gradient localized spectral maps, the low spatial resolution that can be achieved ...

journal_title：NMR in biomedicine

authors： Sijens PE

更新日期：1998-11-01 00:00:00

abstract：:To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...

journal_title：NMR in biomedicine

authors： Zöllner HJ,Oeltzschner G,Schnitzler A,Wittsack HJ

更新日期：2021-01-01 00:00:00

abstract：:MR Z-spectroscopy allows enhanced imaging contrast on the basis of saturation transfer between the proton pools of cellular compounds and water, occurring via chemical exchange (chemical exchange saturation transfer, CEST) or dipole-dipole coupling (nuclear Overhauser effect, NOE). In previous studies, signals observe...

journal_title：NMR in biomedicine

authors： Zaiss M,Kunz P,Goerke S,Radbruch A,Bachert P

更新日期：2013-12-01 00:00:00

abstract：:Following the development of parallel imaging, parallel transmission describes the use of multiple RF transmit coils. Parallel transmission can be applied to improve RF excitation, in particular, multidimensional, spatially selective RF excitation. For instance, parallel transmission is able to shorten spatially selec...

journal_title：NMR in biomedicine

authors： Katscher U,Börnert P

更新日期：2006-05-01 00:00:00

abstract：:Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...

journal_title：NMR in biomedicine

authors： Kor D,Birkl C,Ropele S,Doucette J,Xu T,Wiggermann V,Hernández-Torres E,Hametner S,Rauscher A

更新日期：2019-07-01 00:00:00

abstract：:The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...

journal_title：NMR in biomedicine

authors： Walker SC,Asadi AK,Hopkins SR,Buxton RB,Prisk GK

更新日期：2015-09-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

journal_title：NMR in biomedicine

authors： Thoma WJ,Uğurbil K

更新日期：1988-04-01 00:00:00

abstract：:T2 relaxation time is a quantitative MRI in vivo surrogate of cerebral tissue damage in multiple sclerosis (MS) patients. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. This study centers on the quantit...

journal_title：NMR in biomedicine

authors： Gracien RM,Reitz SC,Hof SM,Fleischer V,Zimmermann H,Droby A,Steinmetz H,Zipp F,Deichmann R,Klein JC

更新日期：2016-04-01 00:00:00

abstract：:Results are presented from an in vivo study of human skin in which a zig-zag surface coil together with a three-pulse Fourier Series Window (FSW) protocol have been used to obtain minimally contaminated 31P skin spectra of the posterior calf. Phantom experiments indicate that while the fall-off in the B1 field profile...

journal_title：NMR in biomedicine

authors： Cowie AG,Bastin ME,Manners DN,Hands LJ,Styles P,Radda GK

更新日期：1996-08-01 00:00:00

abstract：:The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...

journal_title：NMR in biomedicine

authors： Zhang F,Bai Z,Shi Y,Wang J,Li Y,Yang X

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5  cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...

journal_title：NMR in biomedicine

authors： Chen JH,Mehta RS,Baek HM,Nie K,Liu H,Lin MQ,Yu HJ,Nalcioglu O,Su MY

更新日期：2011-04-01 00:00:00

abstract：:There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the...

journal_title：NMR in biomedicine

authors： Pudakalakatti SM,Uppangala S,D'Souza F,Kalthur G,Kumar P,Adiga SK,Atreya HS

更新日期：2013-01-01 00:00:00

abstract：:The performance of multichannel transmit coil layouts and parallel transmission (pTx) RF pulse design was evaluated with respect to transmit B1 (B1 (+)) homogeneity and specific absorption rate (SAR) at 3 T for a whole body coil. Five specific coils were modeled and compared: a 32-rung birdcage body coil (driven eithe...

journal_title：NMR in biomedicine

authors： Wu X,Zhang X,Tian J,Schmitter S,Hanna B,Strupp J,Pfeuffer J,Hamm M,Wang D,Nistler J,He B,Vaughan TJ,Ugurbil K,Van de Moortele PF

更新日期：2015-10-01 00:00:00

abstract：:High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive growth (in which the blood-brain barrier remains intact) and neoangiogenesis is a major challenge ...

journal_title：NMR in biomedicine

authors： Boult JK,Borri M,Jury A,Popov S,Box G,Perryman L,Eccles SA,Jones C,Robinson SP

更新日期：2016-11-01 00:00:00

abstract：:Quantification of metabolites is a goal of many biomedical NMR studies. To obtain absolute measurements of metabolite concentrations is often both difficult and time-consuming. In this paper a method for determining metabolite concentrations directly is described and validated. It is applicable to studies of amphibian...

journal_title：NMR in biomedicine

authors： Wray S,Wilkie DR

更新日期：1992-05-01 00:00:00

abstract：:1H MR spectroscopy was used to correlate the metabolite signals in 66 untreated metastatic brain tumors with the results of Gd-DTPA enhanced MRI. Cubic volumes containing brain metastases of lung cancer (n = 17), mammary carcinoma (n = 24), melanoma (n = 12) and those originating from other tumors (n = 13) were examin...

journal_title：NMR in biomedicine

authors： Sijens PE,Levendag PC,Vecht CJ,van Dijk P,Oudkerk M

更新日期：1996-04-01 00:00:00

abstract：:The combination of hyperpolarized Xe with chemical exchange saturation transfer (Hyper-CEST) is a powerful NMR technique to detect highly dilute concentrations of Xe binding sites using RF saturation pulses. Crucially, that combination of saturation pulse strength and duration that generates the maximal Hyper-CEST eff...

journal_title：NMR in biomedicine

authors： Kunth M,Witte C,Schröder L

更新日期：2015-06-01 00:00:00

abstract：:Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...

journal_title：NMR in biomedicine

authors： Mancini L,Davies L,Friedlos F,Falck-Miniotis M,Dzik-Jurasz AS,Springer CJ,Leach MO,Payne GS

更新日期：2009-06-01 00:00:00

abstract：:A method to extract shapes of bubble polyhedra from three-dimensional nuclear magnetic resonance image data of foam has been developed. The method consists of four steps: first, to compute series of maximum intensity projection images from the three-dimensional NMR image data of foam to visualize the network structure...

journal_title：NMR in biomedicine

authors： Kashiwagi K,Kose K

更新日期：1997-01-01 00:00:00

abstract：:Lung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time...

journal_title：NMR in biomedicine

authors： Bianchi A,Gobbo OL,Dufort S,Sancey L,Lux F,Tillement O,Coll JL,Crémillieux Y

更新日期：2017-11-01 00:00:00

abstract：:γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved sp...

journal_title：NMR in biomedicine

authors： Sanaei Nezhad F,Anton A,Michou E,Jung J,Parkes LM,Williams SR

更新日期：2018-01-01 00:00:00

abstract：:The increased magnetic susceptibility effects at higher magnetic fields increase the demands for shimming of the B0 field for in vivo MRI and MRS. Both static and dynamic techniques have been developed to compensate for susceptibility-induced field inhomogeneities. In this study, we investigate the impact of and need ...

journal_title：NMR in biomedicine

authors： Boer VO,Luttje MP,Luijten PR,Klomp DW

更新日期：2014-06-01 00:00:00

abstract：:Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...

journal_title：NMR in biomedicine

authors： Nivajärvi R,Olsson V,Hyppönen V,Bowen S,Leinonen HM,Lesch HP,Ardenkjaer-Larsen JH,Gröhn OHJ,Ylä-Herttuala S,Kettunen MI

更新日期：2020-04-01 00:00:00

abstract：:Localization techniques are considered an indispensable part of the clinical spectroscopy examination. The results are often a marked improvement in diagnostic information (amplification), but because of the introduction of new artifacts and the more prolonged examination time, some of the undoubted advantage is lost ...

journal_title：NMR in biomedicine

authors： Ross B,Narasimhan PT,Tropp J,Derby KS

更新日期：1989-12-01 00:00:00

abstract：:Structural high-resolution imaging of the brainstem can be of high importance in clinical practice. However, ultra-high field magnetic resonance imaging (MRI) is still restricted in use due to limited availability. Therefore, quantitative MRI techniques (quantitative susceptibility mapping [QSM], relaxation measuremen...

journal_title：NMR in biomedicine

authors： Straub S,Knowles BR,Flassbeck S,Steiger R,Ladd ME,Gizewski ER

更新日期：2019-09-01 00:00:00

abstract：:Bone contains a significant fraction of water that is not detectable with ordinary Cartesian imaging sequences. The advent of ultra-short echo-time (UTE) methods has allowed the recovery of this submillisecond T(2)* water. In this work, we have developed a new three-dimensional hybrid-radial ultra-short echo-time (3D ...

journal_title：NMR in biomedicine

authors： Rad HS,Lam SC,Magland JF,Ong H,Li C,Song HK,Love J,Wehrli FW

更新日期：2011-08-01 00:00:00

abstract：:During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...

journal_title：NMR in biomedicine

authors： Saniour I,Gaborit G,Perrier AL,Gillette L,Revillod G,Sablong R,Duvillaret L,Beuf O

更新日期：2018-01-01 00:00:00