当前位置： SCI文献检索 > NMR IN BIOMEDICINE期刊下所有文献 > Assessment of cortical damage in early multiple sclerosis with quantitative T2 relaxometry.

Assessment of cortical damage in early multiple sclerosis with quantitative T2 relaxometry.

Abstract：

:T2 relaxation time is a quantitative MRI in vivo surrogate of cerebral tissue damage in multiple sclerosis (MS) patients. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. This study centers on the quantitative evaluation of the tissue parameter T2 in cortical NAGM in a collective of early MS and clinically isolated syndrome (CIS) patients, hypothesizing that T2 prolongation is already present at early disease stages and variable over space, in line with global and focal inflammatory processes in MS. Additionally, magnetization transfer ratio (MTR) mapping was performed for further characterization of the expected cortical T2 alteration. Quantitative T2 and MTR maps were acquired from 12 patients with CIS and early MS, and 12 matched healthy controls. The lesion-free part of the cortical volume was identified, and the mean T2 and MTR values and their standard deviations within the cortical volume were determined. For evaluation of spatial specificity, cortical lobar subregions were tested separately for differences of mean T2 and T2 standard deviation. We detected significantly prolonged T2 in cortical NAGM in patients. T2 prolongation was found across the whole cerebral cortex and in all individual lobar subregions. Significantly higher standard deviations across the respective region of interest were found for the whole cerebral cortex and all subregions, suggesting the occurrence of spatially inhomogeneous cortical damage in all regions studied. A trend was observed for MTR reduction and increased MTR variability across the whole cortex in the MS group, suggesting demyelination. In conclusion, our results suggest that cortical damage in early MS is evidenced by spatially inhomogeneous T2 prolongation which goes beyond demyelination. Iron deposition, which is known to decrease T2, seems less prominent.

journal_name

NMR Biomed

journal_title

NMR in biomedicine

authors

Gracien RM,Reitz SC,Hof SM,Fleischer V,Zimmermann H,Droby A,Steinmetz H,Zipp F,Deichmann R,Klein JC

doi

10.1002/nbm.3486

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

444-50

issue

eissn

0952-3480

issn

1099-1492

journal_volume

pub_type

杂志文章

在线工具

Assessment of cortical damage in early multiple sclerosis with quantitative T2 relaxometry.