Abstract:
:Results are presented from an in vivo study of human skin in which a zig-zag surface coil together with a three-pulse Fourier Series Window (FSW) protocol have been used to obtain minimally contaminated 31P skin spectra of the posterior calf. Phantom experiments indicate that while the fall-off in the B1 field profile of the zig-zag surface coil is superior to conventional surface coil designs, it is still not sufficient on its own to reduce muscle signal contamination to acceptable levels in human studies. The additional spatial localization required is provided by the FSW, which reduces signal contamination to less than 30% of the total signal collected. In a study of 18 normal controls the measured pH was found to be relatively high (7.39 +/- 0.08), while the ratios of skin PCr/ beta-ATP (1.04 +/- 0.35) and PCr/Pi (1.67 +/- 0.4) were found to be low compared with that of skeletal muscle. In addition, substantial signal from phosphomonoesters and phosphodiesters were also observed.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Cowie AG,Bastin ME,Manners DN,Hands LJ,Styles P,Radda GKdoi
10.1002/(SICI)1099-1492(199608)9:5<195::AID-NBM416subject
Has Abstractpub_date
1996-08-01 00:00:00pages
195-200issue
5eissn
0952-3480issn
1099-1492pii
10.1002/(SICI)1099-1492(199608)9:5<195::AID-NBM416journal_volume
9pub_type
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abstract::Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...
journal_title:NMR in biomedicine
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doi:10.1002/nbm.1281
更新日期:2008-11-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2010-07-01 00:00:00
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更新日期:2006-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1590
更新日期:2011-07-01 00:00:00
abstract::Blood flow and phosphorus metabolites have been measured simultaneously in the murine RIF-1 tumour in vivo. Blood flow was measured using the H2 washout technique and 31P NMR spectroscopy was used to measure high energy phosphates, inorganic phosphate and intracellular pH within the tumour. Following NMR and flow meas...
journal_title:NMR in biomedicine
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doi:10.1002/nbm.1940030406
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-06-01 00:00:00
abstract::Phosphorus MRSI (31 P-MRSI) using a spiral-trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunte...
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract::One of the hallmarks of diffusion NMR and MRI is its ability to utilize restricted diffusion to probe compartments much smaller than the excited volume or the MRI voxel, respectively, and to extract microstructural information from them. Single-pulsed field gradient (s-PFG) MR methodologies have been employed with gre...
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pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
abstract::The intimal and medial linings of the pulmonary artery consist largely of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), respectively. The migration of these cell types to a potential tissue-engineered pulmonary valve (TEPV) implant process is therefore of interest in understanding the val...
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更新日期:2012-03-01 00:00:00
abstract::Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...
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abstract::Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...
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更新日期:2020-10-01 00:00:00