Abstract:
:Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, with emphasis on the use of MRI to analyze cardiovascular and neural development in mice. Comparisons are made with other imaging technologies, including optical and ultrasound imaging, discussing the potential strengths and weaknesses of MRI and identifying the future challenges for MRI in mouse developmental biology.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Turnbull DH,Mori Sdoi
10.1002/nbm.1146subject
Has Abstractpub_date
2007-05-01 00:00:00pages
265-74issue
3eissn
0952-3480issn
1099-1492journal_volume
20pub_type
杂志文章,评审abstract::The use of cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated. The method is validated on standard samples of N-acetyl aspartate (NAA) and lactate, and possible sources of error are discussed. Using the STEAM pulse sequence, co...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060114
更新日期:1993-01-01 00:00:00
abstract::Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1511
更新日期:2010-10-01 00:00:00
abstract::We describe and discuss the application of three-dimensional (3D) time-of-flight (TOF) magnetic resonance angiography (MRA) to visualize non-invasively the cerebral vasculature of the rat. MR angiograms of healthy spontaneously hypertensive rats were obtained without the use of contrast agents. Total imaging time rang...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199906)12:4<189::aid-nbm55
更新日期:1999-06-01 00:00:00
abstract::A short-echo spectroscopic imaging sequence extended with a frequency-selective multiple-quantum- coherence technique (Sel-MQC) is presented. The method enables acquisition of a complete water-suppressed proton spectrum with a short echo time and filtering of the J-coupling metabolite, lactate, from co-resonant lipids...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1284
更新日期:2008-11-01 00:00:00
abstract::The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2 -weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone-fed (n = 5) mice, with significant increas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2992
更新日期:2013-11-01 00:00:00
abstract::γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved sp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3847
更新日期:2018-01-01 00:00:00
abstract::Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4250
更新日期:2020-04-01 00:00:00
abstract::The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.784
更新日期:2002-11-01 00:00:00
abstract::In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.714
更新日期:2001-11-01 00:00:00
abstract::Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070503
更新日期:1994-08-01 00:00:00
abstract::A quantitative magnetization transfer (qMT) technique was employed to quantify the ratio of the sizes of the bound and free water proton pools in ex vivo mouse brains. The goal was to determine the pool size ratio sensitivity to myelin. Fixed brains from both shiverer mice and control littermates were imaged. The pool...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1358
更新日期:2009-06-01 00:00:00
abstract::MR Z-spectroscopy allows enhanced imaging contrast on the basis of saturation transfer between the proton pools of cellular compounds and water, occurring via chemical exchange (chemical exchange saturation transfer, CEST) or dipole-dipole coupling (nuclear Overhauser effect, NOE). In previous studies, signals observe...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3021
更新日期:2013-12-01 00:00:00
abstract::With a fixed time to acquire a magnetic resonance (MR) image, time can be spent to acquire better spatial resolution with decrease in signal-to-noise ratio (SNR) or decreased resolution with increase in SNR. This resolution/SNR tradeoff at fixed time has been investigated by a visual rater study using images of ex viv...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1359
更新日期:2009-06-01 00:00:00
abstract::Lung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3790
更新日期:2017-11-01 00:00:00
abstract::Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1375
更新日期:2009-06-01 00:00:00
abstract::(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3371
更新日期:2015-10-01 00:00:00
abstract::The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.898
更新日期:2004-08-01 00:00:00
abstract::31P NMR spectra were obtained from sera of 22 healthy volunteers and 20 patients with multiple myeloma at the time of diagnosis and repeated up to five times during therapy. All spectra consisted of a Pi peak (used as a reference peak) and two peaks from phospholipids (PL): one peak due to phosphatidylethanolamine and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080308
更新日期:1995-05-01 00:00:00
abstract::The accuracy and precision of the quantification of metabolite concentrations in in vivo (1) H NMR spectroscopy are affected by linewidth and signal-to-noise ratio (SNR). To study the effect of both factors in in vivo (1) H NMR spectra acquired at ultrahigh field, a reference spectrum was generated by summing nine in ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2821
更新日期:2013-01-01 00:00:00
abstract::Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940020308
更新日期:1989-09-01 00:00:00
abstract::During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3849
更新日期:2018-01-01 00:00:00
abstract::Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199804)11:2<67::aid-nbm503
更新日期:1998-04-01 00:00:00
abstract::An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1261
更新日期:2008-11-01 00:00:00
abstract::Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2882
更新日期:2013-04-01 00:00:00
abstract::A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...
journal_title:NMR in biomedicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/nbm.4167
更新日期:2019-11-01 00:00:00
abstract::NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4318
更新日期:2020-12-01 00:00:00
abstract::Phosphatidylcholine (PC) metabolism in bovine adrenal chromaffin cells has been studied in vivo with 100 MHz 13C NMR spectroscopy. The incorporation of 13[CH3]choline was examined in cells embedded in 1% agarose strands and perfused at 37 degrees C. The pattern of 13C NMR spectroscopy. The incorporation of [13CH3]chol...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940040304
更新日期:1991-06-01 00:00:00
abstract::Proton NMR spectroscopy of biological fluids has produced interesting results lately. We used the technique to investigate the effects of cryopreservation on primary porcine hepatocytes as successful cryopreservation of primary porcine hepatocytes is of importance to the development of bioartificial liver support syst...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.765
更新日期:2002-05-01 00:00:00
abstract::An MR thermometry method is proposed for measuring in vivo small temperature changes engendered by external RF heat sources. The method relies on reproducible and stable respiration and therefore currently applies to ventilated animals whose breathing is carefully controlled. It first consists in characterizing the st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3232
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to acquire high-quality in vivo (1) H spectra concurrently from two voxels at ultra-high field (7 T) without specialized hardware. To this end, an acquisition scheme was developed in which first-order shims and flip angles are dynamically updated to acquire spectra from both of the brain's mo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3328
更新日期:2015-07-01 00:00:00