Abstract:
:A short-echo spectroscopic imaging sequence extended with a frequency-selective multiple-quantum- coherence technique (Sel-MQC) is presented. The method enables acquisition of a complete water-suppressed proton spectrum with a short echo time and filtering of the J-coupling metabolite, lactate, from co-resonant lipids in one scan. The purpose of the study was to validate this combined pulse sequence in vitro and in vivo. Measurements on phantoms confirmed the feasibility of the method, and, for a practical in vivo application, experiments were carried out on eight tumors from two different tumor models [UT-SCC-8 (n = 4) and SAS (n = 4)]. T(1)- and T(2)-weighted metabolite and lipid ratios were calculated, and the tumors showed different values in the central and outer regions. The ratio of the lipid methylene peak area (1.30 ppm) to choline peak area (3.20 ppm) was significantly (p < 0.01) different in the central tumor area between the two models, and lactate was detected in only three out of four tumors in the SAS tumor line. The present approach of combining short-echo spectroscopic imaging and lactate editing allows the characterization of tumor-specific metabolites such as choline, lipid methylene and methyl resonances as well as lactate in a single scan.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Melkus G,Mörchel P,Behr VC,Kotas M,Flentje M,Jakob PMdoi
10.1002/nbm.1284subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1076-86issue
10eissn
0952-3480issn
1099-1492journal_volume
21pub_type
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更新日期:2021-01-22 00:00:00
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更新日期:2017-11-01 00:00:00
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更新日期:2013-10-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1816
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/nbm.1219
更新日期:2008-06-01 00:00:00
abstract::Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...
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pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
abstract::The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...
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更新日期:2013-12-01 00:00:00
abstract::The purpose of this study was to investigate the reliability of 3D isotropic MRI and quantitative multi-parametric MRI characterization on an orthotopic pancreatic head tumor model in rats. 3D isotropic T2 -weighted MRI was performed as a routine for tumor longitudinal follow-up and volume estimation. Common bile duct...
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更新日期:2017-02-01 00:00:00
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更新日期:1989-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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更新日期:2002-05-01 00:00:00
abstract::Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
abstract::The aim of this study was to acquire high-quality in vivo (1) H spectra concurrently from two voxels at ultra-high field (7 T) without specialized hardware. To this end, an acquisition scheme was developed in which first-order shims and flip angles are dynamically updated to acquire spectra from both of the brain's mo...
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更新日期:2015-07-01 00:00:00
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