Abstract:
:A study was undertaken to determine if the vascular characteristics measured by dynamic contrast-enhanced magnetic resonance imaging (primarily permeability surface area product and extracellular-extravascular tissue volume fraction) would be beneficial in explaining the inter-lesion metabolic heterogeneity displayed by human intracranial tumours. Magnetic resonance spectroscopy was carried out using a single-voxel STEAM sequence and dynamic imaging was carried out using a combination of pre-contrast proton density-weighted FSPGR images (to remove the influence of native tissue T1), bolus injection of Gd-DTPA and subsequent T1-weighted FSPGR dynamic imaging. A two-compartment pharmacokinetic model was employed to determine vascular characteristics. Results obtained from 12 meningiomas suggest a possible correlation between the level of lipids/macromolecules and permeability surface area product, although the confounding issue of extra-voxel contamination arising from lipids in the scalp and skull marrow cannot be ruled out in the more superficial lesions. Results obtained from 11 gliomas (four low and seven high grade) demonstrate that permeability surface area product is not specific for the range of vascular characteristics and metabolite profiles observed in gliomas and is therefore unable to explain metabolic heterogeneity in these lesions.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Manton DJ,Lowry M,Rowland-Hill C,Crooks D,Mathew B,Turnbull LWdoi
10.1002/nbm.675subject
Has Abstractpub_date
2000-12-01 00:00:00pages
449-59issue
8eissn
0952-3480issn
1099-1492journal_volume
13pub_type
杂志文章abstract::The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis usin...
journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-08-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2019-11-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2014-01-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1281
更新日期:2008-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199612)9:8<359::AID-NBM428
更新日期:1996-12-01 00:00:00
abstract::Central obesity is the hallmark of a number of non-inheritable disorders. The advent of imaging techniques such as MRI has allowed for a fast and accurate assessment of body fat content and distribution. However, image analysis continues to be one of the major obstacles to the use of MRI in large-scale studies. In thi...
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pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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更新日期:2018-10-01 00:00:00
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更新日期:2013-04-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3504
更新日期:2016-05-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940050402
更新日期:1992-07-01 00:00:00