Abstract:
:In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Nevertheless, the technique is currently mainly used in a research setting. This review provides an overview of the state-of-the-art of three-dimensional MRSI, including the specific hardware required, dedicated data acquisition sequences and information on the spectral content with background on the MR-visible metabolites. In clinical practice, it is important that relevant MRSI results become available rapidly, reliably and in an easy digestible way. However, this functionality is currently not fully available for prostate MRSI, which is a major obstacle for routine use by inexperienced clinicians. Routine use requires more automation in the processing of raw data than is currently available. Therefore, we pay specific attention in this review on the status and prospects of the automated handling of prostate MRSI data, including quality control. The clinical potential of three-dimensional MRSI of the prostate is illustrated with literature examples on prostate cancer detection, its localisation in the prostate, its role in the assessment of cancer aggressiveness and in the selection and monitoring of therapy.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Kobus T,Wright AJ,Scheenen TW,Heerschap Adoi
10.1002/nbm.2973subject
Has Abstractpub_date
2014-01-01 00:00:00pages
39-52issue
1eissn
0952-3480issn
1099-1492journal_volume
27pub_type
杂志文章,评审abstract::Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3619
更新日期:2017-04-01 00:00:00
abstract::The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single-voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi-TE single-voxel STEAM MRS data of a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4439
更新日期:2020-11-17 00:00:00
abstract::This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.707
更新日期:2001-06-01 00:00:00
abstract::In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.714
更新日期:2001-11-01 00:00:00
abstract::Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibili...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4195
更新日期:2020-03-01 00:00:00
abstract::The aim of this study was to analyze Na+ fluxes in whole perfused hearts using Li+ as a Na+ congener and 7Li-nuclear magnetic resonance as a detection method. Hearts were equilibrated for 32 min with 15 mM LiCl added to P1-free Krebs-Henseleit buffer (intracellular space (ICS) [Li+] = 21.5 +/- 3.4 mM). Li+ efflux was ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199709)10:6<271::aid-nbm47
更新日期:1997-09-01 00:00:00
abstract::A noise figure and noise parameter measurement system was developed that consists of a combination spectrum and network analyzer, preamplifier, programmable power supply, noise source, tuning board, and desktop computer. The system uses the Y-factor method for noise figure calculation and allows calibrations to correc...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3138
更新日期:2014-08-01 00:00:00
abstract::Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions of inflammation and hypoxia to the lung's metabolic shift to glycolysis in an experimental animal mode...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4380
更新日期:2020-11-01 00:00:00
abstract::In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3839
更新日期:2018-01-01 00:00:00
abstract::Blood flow and phosphorus metabolites have been measured simultaneously in the murine RIF-1 tumour in vivo. Blood flow was measured using the H2 washout technique and 31P NMR spectroscopy was used to measure high energy phosphates, inorganic phosphate and intracellular pH within the tumour. Following NMR and flow meas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940030406
更新日期:1990-08-01 00:00:00
abstract::In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2802
更新日期:2012-11-01 00:00:00
abstract::Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940020308
更新日期:1989-09-01 00:00:00
abstract::(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3371
更新日期:2015-10-01 00:00:00
abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940010207
更新日期:1988-04-01 00:00:00
abstract::Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4475
更新日期:2021-01-21 00:00:00
abstract::We propose a very high-resolution, three-dimensional (3D) gradient-echo technique with a twofold parallel imaging acceleration using a specialized occipital receiver coil at 3 T to perform functional MRI (fMRI) of the visual cortex. This configuration makes it possible to acquire 3D fMRI data within a timescale compat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1158
更新日期:2007-08-01 00:00:00
abstract::A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199605)9:3<135::AID-NBM404
更新日期:1996-05-01 00:00:00
abstract::The development and implementation of novel MRI pulse sequences remains challenging and laborious. Gradient waveforms are typically designed using a combination of analytical and ad hoc methods to construct each gradient waveform axis independently. This strategy makes coding the pulse sequence complicated, in additio...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4308
更新日期:2020-12-01 00:00:00
abstract::The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2 -weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone-fed (n = 5) mice, with significant increas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2992
更新日期:2013-11-01 00:00:00
abstract::T2 of NAA, creatine and choline-containing compounds were measured in posterior frontal white matter and occipital grey matter in 10 healthy human volunteers. Decay curves comprised signals from eight TE times ranging from 30 to 800 ms with TR 2000 ms acquired with a PRESS sequence on a 1.5 T clinical scanner. Simulat...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.916
更新日期:2005-02-01 00:00:00
abstract::133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.909
更新日期:2005-04-01 00:00:00
abstract::Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3056
更新日期:2014-02-01 00:00:00
abstract::The significance of NMR water diffusion measurements performed at short diffusion times (< 10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070703
更新日期:1994-11-01 00:00:00
abstract::The aim of this work was to identify spectral markers of cell proliferation that could be of use in clinical MRS. Cultured C6 ATCC rat glioma cells were used as models for this purpose and metabolites were extracted with perchloric acid at three different growth curve stages: log, confluence and post-confluence. 1D an...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1024
更新日期:2006-04-01 00:00:00
abstract::Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199804)11:2<67::aid-nbm503
更新日期:1998-04-01 00:00:00
abstract::The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4176
更新日期:2019-12-01 00:00:00
abstract::In recent years considerable effort has been devoted to applying pattern recognition techniques to the complex task of data analysis in magnetic resonance spectroscopy. It may be argued that such techniques will facilitate putting MRS technology to practical clinical use. This paper reviews approaches of pattern recog...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(199705)10:3<99::aid-nbm461
更新日期:1997-05-01 00:00:00
abstract::A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...
journal_title:NMR in biomedicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/nbm.4167
更新日期:2019-11-01 00:00:00
abstract::Quantitative analysis of extracts from two Ehrlich ascites tumour cell lines (Lettre cells) by 19F NMR in vitro demonstrated that one Lettre cell line (designated LLM) metabolized 30-50% less 5-fluorouracil to 5-fluoronucleotides when compared to the other cell line (designated LHM). HPLC analysis of these cellular ex...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940040605
更新日期:1991-12-01 00:00:00
abstract::The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3006
更新日期:2013-12-01 00:00:00