An NMR blood test for cancer: a critical assessment.

abstract：:Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibili...

journal_title：NMR in biomedicine

authors： Peng SL,Yang HC,Chen CM,Shih CT

更新日期：2020-03-01 00:00:00

abstract：:The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2 -weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone-fed (n = 5) mice, with significant increas...

journal_title：NMR in biomedicine

authors： Thiessen JD,Zhang Y,Zhang H,Wang L,Buist R,Del Bigio MR,Kong J,Li XM,Martin M

更新日期：2013-11-01 00:00:00

abstract：:Previous studies have demonstrated that using hyperpolarized [2-13 C]pyruvate as a contrast agent can reveal 13 C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-13 C]pyruvate are the result of several metabolic st...

journal_title：NMR in biomedicine

authors： Chen AP,Lau AZ,Gu YP,Schroeder MA,Barry J,Cunningham CH

更新日期：2018-01-01 00:00:00

abstract：:Encoding of spatial information in magnetic resonance imaging is conventionally accomplished by using magnetic field gradients. During gradient encoding, the position in k-space is determined by a time-integral of the gradient field, resulting in a limitation in imaging speed due to either gradient power or secondary ...

journal_title：NMR in biomedicine

authors： Wright SM,McDougall MP

更新日期：2009-11-01 00:00:00

abstract：:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...

journal_title：NMR in biomedicine

authors： Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5  cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...

journal_title：NMR in biomedicine

authors： Chen JH,Mehta RS,Baek HM,Nie K,Liu H,Lin MQ,Yu HJ,Nalcioglu O,Su MY

更新日期：2011-04-01 00:00:00

abstract：:Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to th...

journal_title：NMR in biomedicine

authors： Podo F

更新日期：1999-11-01 00:00:00

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:The potential use of 13C multilabeled substrates has been studied in biological applications using in vivo and in vitro proton and 13C NMR spectroscopy. In 13C NMR spectroscopy, multilabeled compounds allow the simultaneous observation of several nuclei or increase distinctly the signal to noise ratio due to a higher ...

journal_title：NMR in biomedicine

authors： Künnecke B,Cerdan S

更新日期：1989-12-01 00:00:00

abstract：:An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...

journal_title：NMR in biomedicine

authors： Huang MQ,Pickup S,Nelson DS,Qiao H,Xu HN,Li LZ,Zhou R,Delikatny EJ,Poptani H,Glickson JD

更新日期：2008-11-01 00:00:00

abstract：:Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions of inflammation and hypoxia to the lung's metabolic shift to glycolysis in an experimental animal mode...

journal_title：NMR in biomedicine

authors： Pourfathi M,Xin Y,Rosalino M,Cereda M,Kadlecek S,Duncan I,Profka H,Hamedani H,Siddiqui S,Ruppert K,Chatterjee S,Rizi RR

更新日期：2020-11-01 00:00:00

abstract：:Elevated brain myo-inositol (m-Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a marker...

journal_title：NMR in biomedicine

authors： Gazdzinski SP,Gaździńska AP,Orzeł J,Redlisz-Redlicki G,Pietruszka M,Mojkowska A,Pacho RA,Wylezol M

更新日期：2018-09-01 00:00:00

abstract：:The performance of multichannel transmit coil layouts and parallel transmission (pTx) RF pulse design was evaluated with respect to transmit B1 (B1 (+)) homogeneity and specific absorption rate (SAR) at 3 T for a whole body coil. Five specific coils were modeled and compared: a 32-rung birdcage body coil (driven eithe...

journal_title：NMR in biomedicine

authors： Wu X,Zhang X,Tian J,Schmitter S,Hanna B,Strupp J,Pfeuffer J,Hamm M,Wang D,Nistler J,He B,Vaughan TJ,Ugurbil K,Van de Moortele PF

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...

journal_title：NMR in biomedicine

authors： Otto LAM,Froeling M,van Eijk RPA,Asselman FL,Wadman R,Cuppen I,Hendrikse J,van der Pol WL

更新日期：2021-01-22 00:00:00

abstract：:T2 relaxation time is a quantitative MRI in vivo surrogate of cerebral tissue damage in multiple sclerosis (MS) patients. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. This study centers on the quantit...

journal_title：NMR in biomedicine

authors： Gracien RM,Reitz SC,Hof SM,Fleischer V,Zimmermann H,Droby A,Steinmetz H,Zipp F,Deichmann R,Klein JC

更新日期：2016-04-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes fo...

journal_title：NMR in biomedicine

authors： Furuyama JK,Nagarajan R,Roberts CK,Lee CC,Hahn TJ,Thomas MA

更新日期：2014-10-01 00:00:00

abstract：:In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...

journal_title：NMR in biomedicine

authors： Grinberg F,Ciobanu L,Farrher E,Shah NJ

更新日期：2012-11-01 00:00:00

abstract：:A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...

journal_title：NMR in biomedicine

authors： Richter J,Rabe D,Duysen K,Melchert UH,Oltmanns KM

更新日期：2019-11-01 00:00:00

abstract：:31P Nuclear magnetic resonance spectroscopy has been used to investigate the combined effect of 70 mM ethanol administration and hypoxia on the energetic metabolism and cytosolic pH of the perfused liver isolated from naive, fasted or chronically ethanol-treated rats. Ethanol-treatment or fasting induce a similar 25% ...

journal_title：NMR in biomedicine

authors： Desmoulin F,Canioni P,Masson S,Gérolami A,Cozzone PJ

更新日期：1990-06-01 00:00:00

abstract：:The application of 31P MR spectroscopy in the characterization and treatment of malignant human extremity tumors is reviewed and placed in the perspective of results obtained in murine sarcomas. Despite the now widespread acquisition of gradient localized spectral maps, the low spatial resolution that can be achieved ...

journal_title：NMR in biomedicine

authors： Sijens PE

更新日期：1998-11-01 00:00:00

abstract：:Traditional methods of measuring magnetization in magnetic fluid samples, such as vibrating sample magnetometry (VSM), are typically limited to maximum field strengths of about 1 T. This work demonstrates the ability of MRI to measure the magnetization associated with two commercial MRI contrast agents at 3 T by compa...

journal_title：NMR in biomedicine

authors： Cantillon-Murphy P,Wald LL,Zahn M,Adalsteinsson E

更新日期：2009-10-01 00:00:00

abstract：:A noise figure and noise parameter measurement system was developed that consists of a combination spectrum and network analyzer, preamplifier, programmable power supply, noise source, tuning board, and desktop computer. The system uses the Y-factor method for noise figure calculation and allows calibrations to correc...

journal_title：NMR in biomedicine

authors： Lagore RL,Roberts BR,Possanzini C,Saylor C,Fallone BG,De Zanche N

更新日期：2014-08-01 00:00:00

abstract：:At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...

journal_title：NMR in biomedicine

authors： Marjańska M,Auerbach EJ,Valabrègue R,Van de Moortele PF,Adriany G,Garwood M

更新日期：2012-02-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST) potentially provides the ability to detect small solute pools through indirect measurements of attenuated water signals. However, CEST effects may be diluted by various competing effects, such as non-specific magnetization transfer (MT) and asymmetric MT effects, water long...

journal_title：NMR in biomedicine

authors： Li H,Zu Z,Zaiss M,Khan IS,Singer RJ,Gochberg DF,Bachert P,Gore JC,Xu J

更新日期：2015-02-01 00:00:00

abstract：:Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, wit...

journal_title：NMR in biomedicine

authors： Turnbull DH,Mori S

更新日期：2007-05-01 00:00:00

abstract：:Raised concentrations of glucose for extended periods of time have detrimental effects on the insulin-producing beta-cell. As de novo synthesis of lipids has been observed under such conditions, it was hypothesized that newly formed lipids may preferentially contain saturated fatty acids, which in particular have been...

journal_title：NMR in biomedicine

authors： Nyblom HK,Nord LI,Andersson R,Kenne L,Bergsten P

更新日期：2008-05-01 00:00:00

abstract：:Human tumor and skeletal muscle tissue was studied by means of in vivo 1H, 31P, and 13C MRS. The examinations were performed with a 1.5 T whole-body MR scanner equipped with a second RF system. Localized 1H and broadband proton-decoupled 31P and 13C MR spectra were obtained in measurement times of 5, 10 and 33 min, re...

journal_title：NMR in biomedicine

authors： Bachert P,Bellemann ME,Layer G,Koch T,Semmler W,Lorenz WJ

更新日期：1992-07-01 00:00:00

abstract：:A novel and fast time-domain quantitation algorithm--quantitation based on semi-parametric quantum estimation (QUEST)--invoking optimal prior knowledge is proposed and tested. This nonlinear least-squares algorithm fits a time-domain model function, made up from a basis set of quantum-mechanically simulated whole-meta...

journal_title：NMR in biomedicine

authors： Ratiney H,Sdika M,Coenradie Y,Cavassila S,van Ormondt D,Graveron-Demilly D

更新日期：2005-02-01 00:00:00

abstract：:Studies of cholesteryl ester transfer protein (CETP) function in lipoprotein mixtures pose many difficulties by conventional biochemical methods. For instance, studies on the effects of CETP on the composition of apolipoprotein B containing lipoproteins (very low and low density lipoproteins) in lipoprotein mixtures a...

journal_title：NMR in biomedicine

authors： Korhonen A,Ala-Korpela M,Liinamaa MJ,Jokisaari J,Kesäniemi YA,Savolainen MJ

更新日期：1997-10-01 00:00:00