Abstract:
:Steroidogenic factor-1 (SF-1) is a transcription factor involved in regulation of steroidogenic enzymes. Recent evidence indicates that SF-1 is also important in the anterior pituitary gland, where it may influence gene expression in gonadotropes. We isolated a cDNA encoding ovine SF-1 and demonstrated that the SF-1 gene is expressed in the anterior pituitary gland of sheep. SF-1 transcripts and luteinizing hormone (LH) were colocalized in gonadotropes by in situ hybridization and immunohistochemistry, respectively. To test the hypothesis that GnRH stimulates pituitary expression of ovine SF-1 mRNA, ewes were ovariectomized to increase endogenous secretion of GnRH. Compared to ovary-intact ewes, ovariectomy resulted in three- and fourfold increases in steady-state amounts of mRNA encoding SF-1 and LH beta subunit, respectively. In ovariectomized ewes in which delivery of GnRH to the anterior pituitary gland was prevented by hypothalamic-pituitary disconnection (HPD), steady-state amounts of mRNA encoding SF-1 and LH beta-subunit were decreased. These results provide evidence that pituitary SF-1 gene expression in sheep is regulated by GnRH. Coordinate regulation of mRNAs encoding SF-1 and LH beta-subunit raises the possibility that SF-1 may be an important transcriptional regulator of LH beta-subunit gene expression in ovine gonadotropes.
journal_name
Endocrinejournal_title
Endocrineauthors
Turzillo AM,Quirk CC,Juengel JL,Nett TM,Clay CMdoi
10.1007/BF02820500subject
Has Abstractpub_date
1997-06-01 00:00:00pages
251-6issue
3eissn
1355-008Xissn
1559-0100journal_volume
6pub_type
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