Role of chaperones in nuclear translocation and transactivation of steroid receptors.

abstract：:The application of a hemolytic plaque assay to antigen-secreting endocrine cells has brought about great advances in the study of regulation of hormone secretion. The reverse hemolytic plaque assay (RHPA) has enabled quantitation of secretion at the single cell level with simultaneous analysis of the population respon...

journal_title：Endocrine

authors： Gregerson KA

更新日期：1995-05-01 00:00:00

abstract：:Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the as...

journal_title：Endocrine

authors： Li Y,Tian XX,Liu T,Wang RT

更新日期：2015-05-01 00:00:00

abstract：:Cardiovascular morbidity and mortality are increased in patients with primary hyperparathyroidism (PHPT). We aimed to evaluate left ventricle systolic and diastolic functions with tissue Doppler imaging (TDI) and strain and strain rate echocardiography in patients with PHPT. Thirty-one patients with PHPT and 29 health...

journal_title：Endocrine

authors： Ozdemir D,Kalkan GY,Bayram NA,Onal ED,Ersoy R,Bozkurt E,Cakir B

更新日期：2014-11-01 00:00:00

abstract：:The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D-deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecal...

journal_title：Endocrine

authors： Pepe J,Mezzaroma I,Fantauzzi A,Falciano M,Salotti A,Di Traglia M,Diacinti D,Biondi P,Cipriani C,Cilli M,Minisola S

更新日期：2016-07-01 00:00:00

abstract：:Effects of hypothyroidism on the glucose and insulin levels are controversial, and its impact on the Langerhans islet morphology of adult subjects has been poorly addressed. In spite of hypothyroidism and diabetes mellitus are more frequent in females than in males, most studies using animal models have been done in m...

journal_title：Endocrine

authors： Rodríguez-Castelán J,Nicolás L,Morimoto S,Cuevas E

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...

journal_title：Endocrine

authors： Shao Y,Ren H,Lv C,Ma X,Wu C,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:We aimed to investigate different enhancement patterns of solid thyroid nodules on contrast-enhanced ultrasound (CEUS) and then to evaluate the corresponding diagnostic performance in the differentiation of benign and malignant nodules with and without enhancement. 229 solid thyroid nodules in 196 patients who had und...

journal_title：Endocrine

authors： Wu Q,Wang Y,Li Y,Hu B,He ZY

更新日期：2016-08-01 00:00:00

abstract：:Alendronate is a well-established treatment for osteoporosis and suppresses bone resorption by a direct effect on osteoclasts and their precursors. The effect of alendronate on osteoclasts is produced, at least in part, by the receptor activator of nuclear factor kappaB ligand (RANKL) and the osteoprotegerin (OPG) syn...

journal_title：Endocrine

authors： Enjuanes A,Ruiz-Gaspà S,Peris P,Ozalla D,Alvarez L,Combalia A,Martínez de Osaba MJ,Monegal A,Pares A,Guañabens N

更新日期：2010-04-01 00:00:00

abstract：:Our aim was to evaluate the effectiveness of off-label use of sunitinib in patients with advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAI) therapy. We performed a retrospective analysis of patients treated in the setting of clinical practice in a University General Hospital. Eleven...

journal_title：Endocrine

authors： Díez JJ,Iglesias P,Alonso T,Grande E

更新日期：2015-03-01 00:00:00

abstract：:It is well established that hypothalamic dopamine (DA) is the major physiologic regulator of prolactin (PRL) secretion, exerting a tonic inhibition throughout most of the estrous cycle. A dramatic drop in the amount of DA perfusing the anterior pituitary occurs in the afternoon of proestrus and is critical for the pro...

journal_title：Endocrine

authors： Gregerson KA

更新日期：2003-02-01 00:00:00

abstract：:Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tom...

journal_title：Endocrine

authors： Ulivieri FM,Silva BC,Sardanelli F,Hans D,Bilezikian JP,Caudarella R

更新日期：2014-11-01 00:00:00

abstract：:The oncogenic activation of the rearranged during transfection (RET) proto-oncogene has a main role in the pathogenesis of medullary thyroid cancer (MTC). Several lines of evidence suggest that RET function could be influenced by cyclic AMP (cAMP)-dependent protein kinase A (PKA) activity. We evaluated the in vitro an...

journal_title：Endocrine

authors： Dicitore A,Grassi ES,Caraglia M,Borghi MO,Gaudenzi G,Hofland LJ,Persani L,Vitale G

更新日期：2016-01-01 00:00:00

abstract：:The treatment of acromegaly is based on surgery, drugs, and radiotherapy as a third-line option. Fractionated stereotactic radiotherapy (FSRT) is a new technique with a need for long-term evaluation. The purpose of the study was to evaluate long-term results of FSRT in acromegaly. Overall, 34 patients [sex ratio 1.12,...

journal_title：Endocrine

authors： Diallo AM,Colin P,Litre CF,Diallo MM,Decoudier B,Bertoin F,Higel B,Patey M,Rousseaux P,Delemer B

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of mi...

journal_title：Endocrine

authors： Hu Y,Zhang X,Cui M,Su Z,Wang M,Liao Q,Zhao Y

更新日期：2018-05-01 00:00:00

abstract：CONTEXT:To prepare for radioactive iodine therapy in post total thyroidectomy patients with well-differentiated thyroid cancer (WDTC), either thyroid hormone withdrawal (THW) or administration of recombinant human thyrotropin (rhTSH) can be performed. OBJECTIVE:Our objective is to compare quality of life (QoL) paramet...

journal_title：Endocrine

authors： Tang CYL,Thang SP,Zaheer S,Kwan CK,Ng DC

更新日期：2020-07-01 00:00:00

abstract：:Previous evidence supports a role for growth hormone (GH)-insulin-like growth factor (IGF)-I deficiency in the pathophysiology of osteopenia/osteoporosis in adult thalassemia. Moreover, serum IGF-II has never been studied in this clinical condition. Thus, we elected to study the GH secretory status and the levels of c...

journal_title：Endocrine

authors： Scacchi M,Danesi L,Cattaneo A,Sciortino G,Radin R,Ambrogio AG,Vitale G,D'Angelo E,Mirra N,Zanaboni L,Arvigo M,Boschetti M,Ferone D,Marzullo P,Baldini M,Cassinerio E,Cappellini MD,Persani L,Cavagnini F

更新日期：2016-08-01 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...

journal_title：Endocrine

authors： Deng W,Li Y,Ren Z,He Q,Jia Y,Liu Y,Zhang W,Gan X,Liu D

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin ...

journal_title：Endocrine

authors： Gordon HM,Majithia N,MacDonald PE,Fox JEM,Sharma PR,Byrne FL,Hoehn KL,Evans-Molina C,Langman L,Brayman KL,Nunemaker CS

更新日期：2017-06-01 00:00:00

abstract：:Genetic mutations of steroidogenic factor 1 (also known as Ad4BP or Nr5a1) have increasingly been reported in patients with 46,XY disorders of sex development (46,XY disorders of sex development). However, because the phenotype of 46,XY disorders of sex development with a steroidogenic factor 1 mutation is wide-rangin...

journal_title：Endocrine

authors： Hatano M,Migita T,Ohishi T,Shima Y,Ogawa Y,Morohashi KI,Hasegawa Y,Shibasaki F

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Thiazolidinediones (TZDs) improve peripheral insulin sensitivity, but the effect on arterial stiffness is less clear. The aim of the present study was to assess the differential effect of pioglitazone or rosiglitazone on arterial stiffness and plasma levels of adiponectin and leptin in patients with type 2 d...

journal_title：Endocrine

authors： Oz O,Tuncel E,Eryilmaz S,Fazlioglu M,Gul CB,Ersoy C,Ocak N,Dirican M,Cangur S,Baran I,Imamoglu S

更新日期：2008-02-01 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorph...

journal_title：Endocrine

authors： Gu SJ,Chen DH,Guo ZR,Zhou ZY,Hu XS,Wu M

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Non-functioning pituitary adenomas (NFPA) have a substantial impact on patients' health status, yet research on the extent of healthcare utilization and costs among these patients is scarce. The objective was to determine healthcare usage, associated costs, and their determinants among patients treated for an N...

journal_title：Endocrine

authors： Lobatto DJ,van den Hout WB,Zamanipoor Najafabadi AH,Steffens ANV,Andela CD,Pereira AM,Peul WC,van Furth WR,Biermasz NR,Vliet Vlieland TPM

更新日期：2019-05-01 00:00:00

abstract：:The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

journal_title：Endocrine

authors： Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

更新日期：2013-04-01 00:00:00

abstract：:Increasing evidence suggests that inflammatory response may be a critical component of different brain pathologies. However, the role played by this reaction is not fully understood. The present findings suggest that neuroinflammtory mediators such as cytokines may be involved in a number of key steps in the pathologi...

journal_title：Endocrine

authors： Członkowska A,Ciesielska A,Gromadzka G,Kurkowska-Jastrzebska I

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). DESIGN AND METHODS:Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assesse...

journal_title：Endocrine

authors： Buchs AE,Zehavi S,Sher O,Yeheskely E,Muggia-Sulam M,Sherman Y,Rapoport MJ

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:11β-hydroxylase deficiency accounts for 5% of congenital adrenal hyperplasia cases. Diagnosis suspiction is classically based on the association between abnormal virilization, precocious puberty, and hypertension in 46XX or 46XY subjects. We investigated two families with siblings presenting with opposed clinic...

journal_title：Endocrine

authors： Valadares LP,Pfeilsticker ACV,de Brito Sousa SM,Cardoso SC,de Moraes OL,Gonçalves de Castro LC,de Oliveira RS,Lofrano-Porto A

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS:Immunohistochem...

journal_title：Endocrine

authors： Sotelo-Rivera I,Cote-Vélez A,Uribe RM,Charli JL,Joseph-Bravo P

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:In previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, ...

journal_title：Endocrine

authors： Toorop AA,van der Voorn B,Hollanders JJ,Dijkstra LR,Dolman KM,Heijboer AC,Rotteveel J,Honig A,Finken MJJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Data on the prevalence and type of endocrine disorders in β-thalassemia intermedia (β-TI) patients are scarce. This multicenter study was designed to determine the prevalence of endocrine complications and the associated risk factors in a large group of β-TI patients. METHODS:In this cross-sectional multice...

journal_title：Endocrine

authors： Karimi M,Zarei T,Haghpanah S,Azarkeivan A,Kattamis C,Ladis V,Kattamis A,Kilinc Y,Daar S,Alyaarubi S,Khater D,Wali Y,Elshinawy M,Almadhani A,Yassin M,Soliman AT,Canatan D,Obiedat M,Al-Rimawi H,Mariannis D,Christodo

更新日期：2020-07-01 00:00:00

abstract：:Variants of growth hormone (GH) are present in most vertebrates. Chicken GH (cGH) undergoes posttranslational modifications that contribute to its structural diversity. Although the 22-kDa form of GH is the most abundant, some other variants have discrete bioactivities that may not be shared by others. The proportion ...

journal_title：Endocrine

authors： Martínez-Coria H,López-Rosales LJ,Carranza M,Berumen L,Luna M,Arámburo C

更新日期：2002-03-01 00:00:00