Abstract:
:The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D-deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecalciferol in vitamin D-deficient HIV-1 postmenopausal women undergoing treatment with highly active anti-retroviral therapy (cART), with and without PIs. Forty HIV-1 postmenopausal women treated with cART, with hypovitaminosis D (<20 ng/ml), were enrolled. We measured serum changes of 25-hydroxyvitamin D [25(OH)D]; 1,25-dihydroxyvitamin D [1,25(OH)2D], parathyroid hormone (PTH), serum calcium, and urinary calcium excretion following a loading dose of 600,000 IU of cholecalciferol after 3, 30, 60, 90, and 120 days. Patients were divided into two groups, whether or not they were taking PI. A significant increase in mean 25(OH)D and 1,25(OH)2D levels at day 3 and throughout the entire observation period was found in both groups (p < 0.001). PTH levels concomitantly decreased in both groups (p < 0.001). Mean albumin-adjusted serum calcium increases with respect to baseline were significant only at day 3 and day 30 for both groups (p < 0.01). Considering remaining parameters, there were no significant differences between the groups at any time, by two-way RM ANOVA. An oral dose of 600,000 IU of cholecalciferol in HIV-1 postmenopausal women rapidly increases 25(OH)D and 1,25(OH)2D levels reducing PTH levels, regardless of the presence of PIs in the cART scheme.
journal_name
Endocrinejournal_title
Endocrineauthors
Pepe J,Mezzaroma I,Fantauzzi A,Falciano M,Salotti A,Di Traglia M,Diacinti D,Biondi P,Cipriani C,Cilli M,Minisola Sdoi
10.1007/s12020-015-0693-8subject
Has Abstractpub_date
2016-07-01 00:00:00pages
299-304issue
1eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-015-0693-8journal_volume
53pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract:PURPOSE:To evaluate the reliability of intermittent intraoperative neuromonitoring (I-IONM) through recurrent laryngeal nerve (RLN) stimulation and laryngeal palpation in predicting postoperative vocal cord palsy and to examine the reliability of this technique in providing useful information in the decision to perform...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1739-5
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1398-y
更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS:Members of...
journal_title:Endocrine
pub_type: 杂志文章,实务指引
doi:10.1007/s12020-017-1290-9
更新日期:2017-05-01 00:00:00
abstract::Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0038-4
更新日期:2014-05-01 00:00:00
abstract::Regulation of energy homeostasis is tightly controlled by the central nervous system (CNS). Several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-015-0658-y
更新日期:2015-11-01 00:00:00
abstract::The purpose of the study was to determine whether impaired beta-cell function exists in Chinese individuals within the normal range of glucose tolerance (NGT), and these individuals are predisposed to diabetes later in life. The cross-sectional study included 843 NGT subjects and 562 isolated impaired glucose toleranc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0244-8
更新日期:2015-02-01 00:00:00
abstract::A great number of prospective studies have investigated the relationship between leisure time physical activity (LTPA) and metabolic syndrome (MetS) risk. However, the results have been inconsistent. The aim of this study was to clarify the relationship between LTPA and MetS risk. Literature databases were searched in...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-013-0110-0
更新日期:2014-06-01 00:00:00
abstract::Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9472-3
更新日期:2011-10-01 00:00:00
abstract::Many aspects of tuberoinfundibular dopaminergic neuronal function are increased by elevated prolactin (PRL) levels, including the activity of tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of dopamine. This study evaluated the roles of calmodulin, cyclic nucleotide-dependent protein kinase, and cal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:16:2:105
更新日期:2001-11-01 00:00:00
abstract::In glucocorticoid-induced osteoporosis (GIO), both bone formation and resorption are altered, however, with a relative prevalence of resorption, consistent with the positive results that have been reported with bisphosphonate treatment. Many studies have investigated the effect of bisphosphonates (BPs), a widely used ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0506-5
更新日期:2015-08-01 00:00:00
abstract::Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress m...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0360-5
更新日期:2015-04-01 00:00:00
abstract::The androgen receptor (AR) plays a critical role in sexual differentiation and in the virilization of the male reproductive system. A clear understanding of AR expression at the early stages of sexual development will help elucidate the sensitivity of perinatal animals to endocrine modulation by external agents, such ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:3:253
更新日期:1998-12-01 00:00:00
abstract::First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0619-5
更新日期:2016-03-01 00:00:00
abstract::Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they co...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0357-0
更新日期:2015-02-01 00:00:00
abstract::Follicle-stimulating hormone is synthesized and secreted as a mixture of heterogeneous isoforms that differ from each other in carbohydrate structure, biological potency, and plasma half-life. The relative abundance of the FSH isoforms will depend on the endocrine status of the donor at the time of sample collection. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:23:2-3:189
更新日期:2004-03-01 00:00:00
abstract::Giant prolactinomas are rare tumors characterized by their large size, compressive symptoms, and extremely high prolactin secretion. The aim of this study is to describe our experience with a series of 16 giant prolactinomas cases in terms of clinical presentation, therapeutic decisions, and final outcomes. Retrospect...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1129-9
更新日期:2017-01-01 00:00:00
abstract::The secreted hepatokine fetuin-A emerges as an independent predictor of type 2 diabetes in adulthood. The overall aims of this study were: (1) to investigate the associations of fetuin-A with adiposity and insulin resistance, as well as its relationship with adipokines, in prepubertal children, and, (2) to evaluate wh...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1009-3
更新日期:2017-05-01 00:00:00
abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract::Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9372-y
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To perform an online survey about the use of Thyroid Imaging Reporting and Data System (TIRADS) classification in Italy. METHODS:An online questionnaire was administered to all members of the Italian Society of Medical and Interventional Radiology (Società Italiana di Radiologia Medica ed Interventistica, SIRM...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02199-3
更新日期:2020-05-01 00:00:00
abstract::Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroid disease (AITD). The aim of the study was to investigate the association of AITD with 25(OH) vitamin D levels in women with polycystic ovary syndrome (PCOS). Fifty women with PCOS were consecutively en...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0745-0
更新日期:2016-08-01 00:00:00
abstract::Leptin is an important hormone that has potent effects on appetite and body weight. The regulation of leptin gene expression and secretion by corticosteroids and insulin was studied in the rat. Adrenalectomy resulted in a significant reduction in leptin gene expression and secretion. The reduction was corrected by hor...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:1:85
更新日期:1998-02-01 00:00:00
abstract:PURPOSE:Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influe...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-020-02536-6
更新日期:2021-01-01 00:00:00
abstract::Fifty children ages 4-10 yr with type 1 diabetes mellitus volunteered to participate in a study to evaluate and compare a new needle-free device developed for growth hormone delivery. Children answered descriptive questions related to nervousness and worry, hurt or pain, redness or bleeding, and stinging and wetness. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:15:1:015
更新日期:2001-06-01 00:00:00
abstract::Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9809-6
更新日期:2013-06-01 00:00:00
abstract::Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1020-8
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:This study investigated trends in chronic glucocorticoid (GC) use in South Korea, and determined the association between chronic GC use and 5-year all-cause mortality. METHODS:A sample cohort was extracted from the South Korean National Health Insurance database. Patients prescribed a continuous dose of GC for...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02382-6
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1786-y
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years. METHODS:A total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01928-7
更新日期:2019-07-01 00:00:00
abstract::The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738959
更新日期:1997-04-01 00:00:00