Abstract:
:Giant prolactinomas are rare tumors characterized by their large size, compressive symptoms, and extremely high prolactin secretion. The aim of this study is to describe our experience with a series of 16 giant prolactinomas cases in terms of clinical presentation, therapeutic decisions, and final outcomes. Retrospective analysis of adult patients diagnosed with giant prolactinomas at the endocrine departments of three university tertiary hospitals. We included 16 patients (43.7 % women); mean age at diagnosis: 42.1 ± 21 years. The most frequent presentation was compressive symptoms. The delay in diagnosis was higher in women (median of 150 months vs. 12 in men; p = 0.09). The mean maximum tumor diameter at diagnosis was 56.9 ± 15.5 mm, and mean prolactin levels were 10,995.9 ± 12,157.8 ng/mL. Dopamine agonists were the first-line treatment in 11 patients (mean maximum dose: 3.9 ± 3.2 mg/week). Surgery was the initial treatment in five patients and the second-line treatment in six. Radiotherapy was used in four cases. All patients but one, are still with dopamine agonists. After a mean follow-up of 9 years, prolactin normalized in 7/16 patients (43.7 %) and 13 patients (81 %) reached prolactin levels lower than twice the upper limit of normal. Mean prolactin level at last visit: 79.5 ± 143 ng/mL. Tumor volume was decreased by 93.8 ± 11.3 %, and final maximum tumor diameter was 18.4 ± 18.8 mm. Three patients are actually tumor free. Giant prolactinomas are characterized by a large tumor volume and extreme prolactin hypersecretion. Multimodal treatment is frequently required to obtain biochemical and tumor control.
journal_name
Endocrinejournal_title
Endocrineauthors
Andujar-Plata P,Villar-Taibo R,Ballesteros-Pomar MD,Vidal-Casariego A,Pérez-Corral B,Cabezas-Agrícola JM,Álvarez-Vázquez P,Serramito R,Bernabeu Idoi
10.1007/s12020-016-1129-9subject
Has Abstractpub_date
2017-01-01 00:00:00pages
231-238issue
1eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-016-1129-9journal_volume
55pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Pituitary tumors are highly vascular neoplasms, which suggest an important role of angiogenesis in pituitary tumor growth. We used the human pituitary cell line (HP75) to examine the effects of the growth factors TGFbeta1, bFGF, and EGF on cell growth, and on the regulation of the pro-angiogenic growth factor VEGF-A a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:2:141
更新日期:2004-07-01 00:00:00
abstract::Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:29:2:341
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1742-x
更新日期:2018-12-01 00:00:00
abstract::Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9372-y
更新日期:2010-10-01 00:00:00
abstract::The therapeutic activity of 131I administered to patients with Graves' disease can be calculated by means of Marinelli's formula. The thyroidal iodine uptake (131IUmax) needed for the calculation is usually determined with the use of 131I. The purpose of the paper was to estimate 131IUmax on the basis of technetium up...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1074-7
更新日期:2016-12-01 00:00:00
abstract::To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:15:1:079
更新日期:2001-06-01 00:00:00
abstract::The bovine corpus luteum contains a myristoylated alanine-rich C kinase substrate (MARCKS) protein known to crosslink actin filaments in the cytoskeletal cortex associated with the plasma membrane. We conducted experiments to determine whether concentrations of MARCKS mRNA and protein in the bovine corpus luteum varie...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:12:3:289
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:To assess the effectiveness and safety of myoinositol for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primar...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-017-1442-y
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:In previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02273-w
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Thiazolidinediones (TZDs) improve peripheral insulin sensitivity, but the effect on arterial stiffness is less clear. The aim of the present study was to assess the differential effect of pioglitazone or rosiglitazone on arterial stiffness and plasma levels of adiponectin and leptin in patients with type 2 d...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-008-9058-x
更新日期:2008-02-01 00:00:00
abstract::We performed this study to investigate the prevalences of insulin resistance and metabolic syndrome (MetS) in a Chinese population with normal weight. We also examined whether fat mass is associated with insulin resistance and MetS in normal-weight individuals. Data were drawn from a cross-sectional study in China. Su...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0079-8
更新日期:2014-08-01 00:00:00
abstract::A mechanism explaining the differential skeletal effects of intermittent and continuous elevation of serum parathyroid hormone (PTH) remains elusive. Intermittent PTH increases bone formation and bone mass and is being investigated as a therapy for osteoporosis. By contrast, chronic hyperparathyroidism results in the ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:17:1:29
更新日期:2002-02-01 00:00:00
abstract::Ascorbate is a reducing agent, which is also known to oxidize cellular components. Our proposed mechanism of the oxidative action is as follows: Ascorbate is concentrated in the pancreas and is leaked in adverse conditions, and oxidized to dehydroascorbate. The dehydroascorbate is carried into cells by a glucose trans...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:1:91
更新日期:2002-06-01 00:00:00
abstract::Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9389-2
更新日期:2010-12-01 00:00:00
abstract::Mammalian reproduction is dependent on both a successful pregnancy and on the subsequent period of lactation. In the rat, ovulation occurs shortly after parturition making it possible for a dam to be simultaneously pregnant and lactating. The present studies investigate the effect of placental hormones on suckling-ind...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738662
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0032-9
更新日期:2007-04-01 00:00:00
abstract::Subacute thyroiditis is a transient inflammatory thyroid disease of unknown etiology. The primary goal for treatment is to mitigate inflammation. The aim of this retrospective study was to compare the therapeutic effects of prednisolone and nonsteroidal anti-inflammation drugs in patients with subacute thyroiditis. In...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1122-3
更新日期:2017-01-01 00:00:00
abstract::Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738705
更新日期:1996-10-01 00:00:00
abstract:PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02069-7
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Angiogenesis has been studied in pituitary neuroendocrine tumours (PitNETs), but the role of the tumour microenvironment (TME) in regulating PitNET angiogenesis remains unknown. We aimed to characterise the role of TME components in determining the angiogenetic PitNET profile, focusing on immune cells and tumou...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02478-z
更新日期:2020-12-01 00:00:00
abstract::Molecular chaperones assist proteins to reach their mature and functional conformation. It has become apparent in recent years that chaperones function as part of a multiprotein heterocomplex that is potentially involved not only in protein folding, but also in intracellular trafficking and in targeting proteins for d...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:14:2:143
更新日期:2001-03-01 00:00:00
abstract::Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:21:2:159
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:Bilateral inferior petrosal sinus sampling (BIPSS) is useful for differential diagnosis of adult Cushing's disease (CD) but may not be so reliable in pediatric cases. The purpose of this study was to evaluate the sensitivity of BIPSS before and after desmopressin stimulation in pediatric CD, and to explore rela...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1779-x
更新日期:2019-03-01 00:00:00
abstract::Plasma levels for insulin-like growth factor-I (IGF-I) steadily increase in female rats between 20 and 40 d of life, and this increase is intimately related to the wellknown growth spurt occurring at this age. Since specific actions of IGF-I related to sexual function have been described at the ovarian and hypothalami...
journal_title:Endocrine
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Many aspects of tuberoinfundibular dopaminergic neuronal function are increased by elevated prolactin (PRL) levels, including the activity of tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of dopamine. This study evaluated the roles of calmodulin, cyclic nucleotide-dependent protein kinase, and cal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:16:2:105
更新日期:2001-11-01 00:00:00
abstract::Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:3:229
更新日期:2004-12-01 00:00:00
abstract::Thickened pituitary stalks (TPSs) on magnetic resonance imaging (MRI) result from diverse pathologies; therefore, it is essential to make specific diagnoses for clinical decision-making. The diagnoses and indications for surgical biopsies in patients with central diabetes insipidus (CDI) and TPSs are thoroughly discus...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-014-0184-3
更新日期:2014-09-01 00:00:00
abstract::The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738959
更新日期:1997-04-01 00:00:00
abstract::In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9048-z
更新日期:2007-12-01 00:00:00
abstract::Leptin is an important hormone that has potent effects on appetite and body weight. The regulation of leptin gene expression and secretion by corticosteroids and insulin was studied in the rat. Adrenalectomy resulted in a significant reduction in leptin gene expression and secretion. The reduction was corrected by hor...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:1:85
更新日期:1998-02-01 00:00:00