Recycling processes of cellular ascorbate generate oxidative stress in pancreatic tissues in in vitro system.

abstract：:RU486 has been reported to be a glucocorticoid receptor (GR) and a progesterone receptor (PR) antagonist. We have analysed RU486 activity on the GR in WCL-2 (CHO) cells and in COS-7 cells transiently transfected with the mouse GR and with the reporter MMTVCAT (MCAT). These cell lines do not contain any active progeste...

journal_title：Endocrine

authors： Zhang S,Danielsen M

更新日期：1995-01-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency predisposes affected individuals highly susceptible to oxidative stress, which is one of the risk factors for diabetes. To evaluate the relationship between blood level of G6PD activity and diabetes in Taiwan, blood G6PD activity was analyzed among 237 patients with ...

journal_title：Endocrine

authors： Wan GH,Tsai SC,Chiu DT

更新日期：2002-11-01 00:00:00

abstract：:There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...

journal_title：Endocrine

authors： Bañón S,Rosillo M,Gómez A,Pérez-Elias MJ,Moreno S,Casado JL

更新日期：2015-06-01 00:00:00

abstract：:To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injecte...

journal_title：Endocrine

authors： Liu F,Chen J,Shi F,Wang T,Watanabe G,Taya K

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid ...

journal_title：Endocrine

authors： Pesenti C,Muzza M,Colombo C,Proverbio MC,Farè C,Ferrero S,Miozzo M,Fugazzola L,Tabano S

更新日期：2018-07-01 00:00:00

abstract：:Steroidogenic factor-1 (SF-1) is a transcription factor involved in regulation of steroidogenic enzymes. Recent evidence indicates that SF-1 is also important in the anterior pituitary gland, where it may influence gene expression in gonadotropes. We isolated a cDNA encoding ovine SF-1 and demonstrated that the SF-1 g...

journal_title：Endocrine

authors： Turzillo AM,Quirk CC,Juengel JL,Nett TM,Clay CM

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:To assess the effectiveness and safety of myoinositol for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primar...

journal_title：Endocrine

authors： Zeng L,Yang K

更新日期：2018-01-01 00:00:00

abstract：:The influence of thyroid hormones on cardiovascular system is well established. Thyroid diseases can effectively enhance the alteration on cardiovascular system by influencing chronotropic and inotropic actions of the heart; altering the strength and the speed of contraction, the speed of relaxation, the duration of t...

journal_title：Endocrine

authors： Scicchitano P,Dentamaro I,Tunzi F,Ricci G,Carbonara S,Devito F,Zito A,Ciampolillo A,Ciccone MM

更新日期：2016-12-01 00:00:00

abstract：:Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1 cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndrome (PCOS) patients. In the present study we evaluated the association of serum IL-18 levels with insulin resi...

journal_title：Endocrine

authors： Zhang YF,Yang YS,Hong J,Gu WQ,Shen CF,Xu M,Du PF,Li XY,Ning G

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). METHODS:Fifty patients who were admitted to endocrinology outpatient clinics ...

journal_title：Endocrine

authors： Eker F,Gungunes A,Durmaz S,Kisa U,Celik ZR

更新日期：2020-09-23 00:00:00

abstract：:Adrenal transplantation may restore adrenal function after bilateral adrenalectomy or when adrenal function is lost. Thus, animal experiments could provide useful information before clinical application of adrenal transplantation. Using an experimental model of autotransplantion of a complete adrenal gland in the sple...

journal_title：Endocrine

authors： Allende G,Chavira R,Quintana-Stephan A

更新日期：2001-12-01 00:00:00

abstract：:Previous evidence supports a role for growth hormone (GH)-insulin-like growth factor (IGF)-I deficiency in the pathophysiology of osteopenia/osteoporosis in adult thalassemia. Moreover, serum IGF-II has never been studied in this clinical condition. Thus, we elected to study the GH secretory status and the levels of c...

journal_title：Endocrine

authors： Scacchi M,Danesi L,Cattaneo A,Sciortino G,Radin R,Ambrogio AG,Vitale G,D'Angelo E,Mirra N,Zanaboni L,Arvigo M,Boschetti M,Ferone D,Marzullo P,Baldini M,Cassinerio E,Cappellini MD,Persani L,Cavagnini F

更新日期：2016-08-01 00:00:00

abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...

journal_title：Endocrine

authors： Hunt N,Willey KP,Abend N,Balvers M,Jähner D,Northemann W,Ivell R

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To evaluate the reliability of intermittent intraoperative neuromonitoring (I-IONM) through recurrent laryngeal nerve (RLN) stimulation and laryngeal palpation in predicting postoperative vocal cord palsy and to examine the reliability of this technique in providing useful information in the decision to perform...

journal_title：Endocrine

authors： Cavicchi O,Burgio L,Cioccoloni E,Piccin O,Macrì G,Schiavon P,Dionigi G

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein sub...

journal_title：Endocrine

authors： Szalat A,Shpitzen S,Tsur A,Zalmon Koren I,Shilo S,Tripto-Shkolnik L,Durst R,Leitersdorf E,Meiner V

更新日期：2017-03-01 00:00:00

abstract：:Effects of hypothyroidism on the glucose and insulin levels are controversial, and its impact on the Langerhans islet morphology of adult subjects has been poorly addressed. In spite of hypothyroidism and diabetes mellitus are more frequent in females than in males, most studies using animal models have been done in m...

journal_title：Endocrine

authors： Rodríguez-Castelán J,Nicolás L,Morimoto S,Cuevas E

更新日期：2015-04-01 00:00:00

abstract：:Renal or hepatic impairment, often encountered in patients with type 2 diabetes, influences the pharmacokinetics and bioavailability of antihyperglycemic agents. An emerging concern is whether pharmacotherapy with incretin-based agents, the most recent drug classes to be introduced for type 2 diabetes, can be safely u...

journal_title：Endocrine

authors： Giorda CB,Nada E,Tartaglino B

更新日期：2014-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been identified to play important functions during osteoblast proliferation, differentiation, and apoptosis. The miR-17~92 cluster is highly conserved in all vertebrates. Loss-of-function of the miR-17-92 cluster results in smaller embryos and immediate postnatal death of all animals. Germline ...

journal_title：Endocrine

authors： Zhou M,Ma J,Chen S,Chen X,Yu X

更新日期：2014-03-01 00:00:00

abstract：:To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...

journal_title：Endocrine

authors： Luo LG,Lee SL,Lechan RM,Jackson IM

更新日期：2001-06-01 00:00:00

abstract：:Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+ concentration ([Ca2+]i), which is determined by Ca2+ influx and release from intracellular Ca2+ storage sites. Ca2+ influx...

journal_title：Endocrine

authors： Han X,Zhu Y,Zhao Y,Chen C

更新日期：2011-10-01 00:00:00

abstract：:Regulation of energy homeostasis is tightly controlled by the central nervous system (CNS). Several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, ...

journal_title：Endocrine

authors： Seoane-Collazo P,Fernø J,Gonzalez F,Diéguez C,Leis R,Nogueiras R,López M

更新日期：2015-11-01 00:00:00

abstract：:Pituitary tumors are highly vascular neoplasms, which suggest an important role of angiogenesis in pituitary tumor growth. We used the human pituitary cell line (HP75) to examine the effects of the growth factors TGFbeta1, bFGF, and EGF on cell growth, and on the regulation of the pro-angiogenic growth factor VEGF-A a...

journal_title：Endocrine

authors： Horiguchi H,Jin L,Ruebel KH,Scheithauer BW,Lloyd RV

更新日期：2004-07-01 00:00:00

abstract：:Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...

journal_title：Endocrine

authors： Cohen LE

更新日期：2000-04-01 00:00:00

abstract：:Adrenal crises are life-threatening complications of adrenal insufficiency. These events have an estimated incidence of between 5 and 10  adrenal crises/100 patient years and are responsible for some of the increased morbidity and excess mortality experienced by patients with adrenal insufficiency. Treatment involves ...

journal_title：Endocrine

authors： Rushworth RL,Torpy DJ,Falhammar H

更新日期：2017-02-01 00:00:00

abstract：PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...

journal_title：Endocrine

authors： Liu R,Xia Y,Chen C,Ye T,Huang X,Ma L,Hu Y,Jiang Y

更新日期：2019-12-01 00:00:00

abstract：:Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...

journal_title：Endocrine

authors： Yongtao Z,Kunzheng W,Jingjing Z,Hu S,Jianqiang K,Ruiyu L,Chunsheng W

更新日期：2014-11-01 00:00:00

abstract：:Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic cell-line, a model for endochondral ossification, were analyzed. For this purpose, real-time PCR, Western blot...

journal_title：Endocrine

authors： Ben-Eliezer M,Phillip M,Gat-Yablonski G

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:The institutional database of the Thyroid Surgery Division in China-Japan Union Hospital of Jilin University was queried to audit time trend patterns in thyroid cancer (TC) management between 2008 and 2017. METHODS:Retrospective longitudinal analysis. Clinicopathological features and treatment strategies were ...

journal_title：Endocrine

authors： Sui C,Liang N,Du R,He Q,Zhang D,Li F,Fu Y,Dionigi G,Sun H

更新日期：2020-06-01 00:00:00

abstract：:The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...

journal_title：Endocrine

authors： Waldmann J,Langer P,Habbe N,Fendrich V,Ramaswamy A,Rothmund M,Bartsch DK,Slater EP

更新日期：2009-06-01 00:00:00

abstract：:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...

journal_title：Endocrine

authors： Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya K

更新日期：2002-06-01 00:00:00