Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome.

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnos...

journal_title：Endocrine

authors： Mayo JC,Sainz RM,Tan DX,Antolín I,Rodríguez C,Reiter RJ

更新日期：2005-07-01 00:00:00

abstract：:Effects of hypothyroidism on the glucose and insulin levels are controversial, and its impact on the Langerhans islet morphology of adult subjects has been poorly addressed. In spite of hypothyroidism and diabetes mellitus are more frequent in females than in males, most studies using animal models have been done in m...

journal_title：Endocrine

authors： Rodríguez-Castelán J,Nicolás L,Morimoto S,Cuevas E

更新日期：2015-04-01 00:00:00

abstract：:In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract...

journal_title：Endocrine

authors： Yang YS,Li XY,Hong J,Gu WQ,Zhang YF,Yang J,Song HD,Chen JL,Ning G

更新日期：2007-12-01 00:00:00

abstract：:Erectile dysfunction (ED) is commonly associated with risk factors for cardiovascular disease, including diabetes. The prevalence of ED in diabetic patients is high--about 75% of diabetic men 60 yr of age or older had ED in one study. Endothelial dysfunction, accelerated atherosclerosis, and diabetic neuropathy likely...

journal_title：Endocrine

authors： Kloner RA

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:The primary aim of this study is to isolate cytokines specific for active Graves' orbitopathy (GO) in the tears of affected patients. The secondary aim is to identify other cytokines of interest and to look at the profile of their levels over time. METHODS:This is a prospective pilot study conducted at the Sin...

journal_title：Endocrine

authors： Yang M,Chung Y,Lang S,Yawata N,Seah LL,Looi A

更新日期：2018-02-01 00:00:00

abstract：:Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...

journal_title：Endocrine

authors： Yang H,Chang J,Chen W,Zhao L,Qu B,Tang C,Qi Y,Zhang J

更新日期：2013-06-01 00:00:00

abstract：:The bovine corpus luteum contains a myristoylated alanine-rich C kinase substrate (MARCKS) protein known to crosslink actin filaments in the cytoskeletal cortex associated with the plasma membrane. We conducted experiments to determine whether concentrations of MARCKS mRNA and protein in the bovine corpus luteum varie...

journal_title：Endocrine

authors： Filley S,Supancic S,Salli U,Orwig K,Stormshak F

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:This study investigated trends in chronic glucocorticoid (GC) use in South Korea, and determined the association between chronic GC use and 5-year all-cause mortality. METHODS:A sample cohort was extracted from the South Korean National Health Insurance database. Patients prescribed a continuous dose of GC for...

journal_title：Endocrine

authors： Oh TK,Song IA

更新日期：2020-09-01 00:00:00

abstract：:Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...

journal_title：Endocrine

authors： Cetin C,Baş F,Uçar A,Poyrazoğlu S,Saka N,Bundak R,Darendeliler F

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Rathke's cleft cysts (RCC) are lesions that arise from Rathke's pouch. Though frequently incidental, resulting symptoms in a minority of cases are indicators for surgical resection, which may prove beneficial. OBJECTIVE:To characterize a cohort of surgically-resected RCC cases at Oregon Health & Science Uni...

journal_title：Endocrine

authors： Langlois F,Manea A,Lim DST,McCartney S,Yedinak CG,Cetas JS,Fleseriu M

更新日期：2019-03-01 00:00:00

abstract：:Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...

journal_title：Endocrine

authors： Vitale G,Tortora F,Baldelli R,Cocchiara F,Paragliola RM,Sbardella E,Simeoli C,Caranci F,Pivonello R,Colao A,A.B.C. Group.

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the p...

journal_title：Endocrine

authors： Aydoğan Y,Altay M,Ünsal O,Kaplanoğlu V,Çağır Y,Yıldız C,Beyan E,Ramadan SU

更新日期：2018-11-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinica...

journal_title：Endocrine

authors： Kurtulmus N,Mert M,Tanakol R,Yarman S

更新日期：2015-04-01 00:00:00

abstract：:Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...

journal_title：Endocrine

authors： Jiang Z,Gui S,Zhang Y

更新日期：2010-12-01 00:00:00

abstract：:The objectives of this study were to analyse the results of surgical treatment of multinodular goiter (MG) in a population with under 30 yr of age; (2) to determine the incidence and evolution of related thyroid carcinomas; and (3) to evaluate the rate of relapse. Eighty-one patients operated for MG and under 30 yr of...

journal_title：Endocrine

authors： Ríos A,Rodríguez JM,Galindo PJ,Montoya MJ,Canteras M,Parrilla P

更新日期：2005-08-01 00:00:00

abstract：:Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...

journal_title：Endocrine

authors： Cohen LE

更新日期：2000-04-01 00:00:00

abstract：:Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...

journal_title：Endocrine

authors： Guaraldi F,Prencipe N,di Giacomo V,Scanarini M,Gasco V,Gardiman MP,Berton AM,Ghigo E,Grottoli S

更新日期：2013-08-01 00:00:00

abstract：:Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they co...

journal_title：Endocrine

authors： Bruyère O,Reginster JY

更新日期：2015-02-01 00:00:00

abstract：:It is well established that hypothalamic dopamine (DA) is the major physiologic regulator of prolactin (PRL) secretion, exerting a tonic inhibition throughout most of the estrous cycle. A dramatic drop in the amount of DA perfusing the anterior pituitary occurs in the afternoon of proestrus and is critical for the pro...

journal_title：Endocrine

authors： Gregerson KA

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:The aim of this study is to investigate in a population of adolescents living in Regione Campania, undergoing sun exposure at least 9 months per year the prevalence of severe deficiency (<20 ng/ml) or insufficiency (21-29 ng/ml) of 25-Hydroxyvitamin D (25(OH)D) levels and its relationship with individual body w...

journal_title：Endocrine

authors： Colao A,Muscogiuri G,Rubino M,Vuolo L,Pivonello C,Sabatino P,Pizzo M,Campanile G,Fittipaldi R,Lombardi G,Di Somma C

更新日期：2015-06-01 00:00:00

abstract：:Our aim was to assess short-term natural course of hypogonadism diagnosed during hospitalization for acute disease in aged male patients after discharge. A group of 43 hypogonadal males, aged 86.7±5.7 year, was studied. Serum concentrations of testosterone (T) and gonadotropins (follicle-stimulating hormone, FSH, and ...

journal_title：Endocrine

authors： Iglesias P,Prado F,Muñoz A,Guerrero MT,Macías MC,Ridruejo E,Tajada P,García-Arévalo C,Díez JJ

更新日期：2015-04-01 00:00:00

abstract：:We investigated the expression and activity of cytosolic phospholipase A2 (cPLA2) in the corpus luteum during spontaneous and induced luteolysis in pseudopregnant rats. In both models, luteal PLA2 activity rose in association with functional regression and persisted during the following structural regression. Tissue c...

journal_title：Endocrine

authors： Kurusu S,Sakaguchi S,Kawaminami M,Hashimoto I

更新日期：2001-04-01 00:00:00

abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...

journal_title：Endocrine

authors： Hunt N,Willey KP,Abend N,Balvers M,Jähner D,Northemann W,Ivell R

更新日期：1995-03-01 00:00:00

abstract：:A substantial number of pregnancies are complicated by gestational diabetes mellitus (GDM) and up to 70 % of women with GDM go on to develop type 2 diabetes. Given the extensive body of research suggesting physical activity reduces the risk of type 2 diabetes, facilitating physical activity, and reducing sedentary tim...

journal_title：Endocrine

authors： Johnson ST,Lynch B,Vallance J,Davenport MH,Gardiner PA,Butalia S

更新日期：2016-04-01 00:00:00

abstract：:Cytoplasmic calcium ([Ca(2+)](i)) changes evoked by adenosine 5(1)-triphosphate (ATP) were recorded in cultured individual Leydig cells within 10-18 h after cell dispersion. [Ca(2+)](i) was monitored using Fura-2AM loaded cells with a digital ratio imaging system. Five micromolars ATP induced biphasic [Ca(2+)](i) resp...

journal_title：Endocrine

authors： Pérez-Armendariz EM,Nadal A,Fuentes E,Spray DC

更新日期：1996-06-01 00:00:00

abstract：:The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...

journal_title：Endocrine

authors： Qiu H,Tang W,Yin P,Cheng F,Wang L

更新日期：2014-03-01 00:00:00

abstract：:The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...

journal_title：Endocrine

authors： Waldmann J,Langer P,Habbe N,Fendrich V,Ramaswamy A,Rothmund M,Bartsch DK,Slater EP

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carc...

journal_title：Endocrine

authors： Biamonte E,Solbiati L,Ierace T,Colombo P,Lavezzi E,Mazziotti G,Lania A

更新日期：2019-09-01 00:00:00

abstract：:There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...

journal_title：Endocrine

authors： Bañón S,Rosillo M,Gómez A,Pérez-Elias MJ,Moreno S,Casado JL

更新日期：2015-06-01 00:00:00

abstract：:Oestradiol (E(2)) alters lymphocyte functionin vitro including T cell DNA synthesis and B cell immunoglobulin production in human tonsillar, splenic and peripheral blood cells. We have investigated whether one mechanism for this effect is that E(2) modifies the expression of IL-2, IL-6 and IFN-γ mRNA in human tonsilla...

journal_title：Endocrine

authors： Evagelatou M,Farrant J

更新日期：1995-11-01 00:00:00