Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats.

Abstract:

:Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent treadmill running at 26 m/min (60 min each, 5 days/week for 8 weeks). High-fat diet induced obesity, with increased body weight, body fat, and lipid profile. The level of IL-15 immunoreactivity (IL-15-ir) in plasma and gastrocnemius muscle was lower in obese than control rats, and the mRNA level of IL-15 in gastrocnemius muscle was markedly decreased. The mRNA and protein levels of IL-15R in adipose tissue were markedly lower in obese rats. Compared with sedentary obese rats, treadmill running showed decreased body weight and elevated mRNA expression of IL-15 in muscle and elevated IL-15-ir level in plasma and muscle. The mRNA and protein level of IL-15R were increased in adipose tissue in treadmill running obese rats. Our results showed that exercise training improve obesity and reversed the downregulation of the IL-15 in muscle and IL-15R in adipose tissue induced by high-fat diet.

journal_name

Endocrine

journal_title

Endocrine

authors

Yang H,Chang J,Chen W,Zhao L,Qu B,Tang C,Qi Y,Zhang J

doi

10.1007/s12020-012-9809-6

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

579-85

issue

3

eissn

1355-008X

issn

1559-0100

journal_volume

43

pub_type

杂志文章
  • Phytosterol additive boosts adrenal response to ACTH in male Japanese quail (Coturnix coturnix japonica).

    abstract::To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injecte...

    journal_title:Endocrine

    pub_type: 信件

    doi:10.1007/s12020-011-9590-y

    authors: Liu F,Chen J,Shi F,Wang T,Watanabe G,Taya K

    更新日期:2012-04-01 00:00:00

  • Anti-Saccaromyces Cerevisiae antibodies (ASCA) are elevated in autoimmune thyroid disease ASCA in autoimmune thyroid disease.

    abstract::Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-010-9372-y

    authors: Yazıcı D,Aydın SZ,Yavuz D,Tarçın O,Deyneli O,Direskeneli H,Akalın S

    更新日期:2010-10-01 00:00:00

  • Exosomal microRNA-29a mediates cardiac dysfunction and mitochondrial inactivity in obesity-related cardiomyopathy.

    abstract:PURPOSE:Present study aims to explore the pathophysiological role of microRNA (miR)-29a in the process of obesity-related cardiomyopathy in human subjects and mice. METHODS:The expression level of circulating exosomal miR-29a was measured in 37 lean and 30 obese human subjects, and correlated with cardiac parameters. ...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-018-1753-7

    authors: Li F,Zhang K,Xu T,Du W,Yu B,Liu Y,Nie H

    更新日期:2019-03-01 00:00:00

  • Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process.

    abstract::Factors affecting longevity are complex and poorly understood. We have recently found that Ames dwarf mice (df/df), which are deficient in growth hormone (GH), prolactin, and thyroid-stimulating hormone, live significantly longer than their normal siblings whereas transgenic mice that overexpress GH exhibit reduced li...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:11:1:41

    authors: Brown-Borg HM,Bode AM,Bartke A

    更新日期:1999-08-01 00:00:00

  • Loss-of-function of SHARPIN causes an osteopenic phenotype in mice.

    abstract::SHARPIN is a novel protein thought to interact with SHANK family and is widely expressed in multiple tissues/cells, including osteoblasts and osteoclasts. Loss-of-function of Sharpin develops the chronic proliferative dermatitis mutation (CPDM) in mice as well as a severe inflammation in other organs. The actual funct...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-010-9418-1

    authors: Xia T,Liang Y,Ma J,Li M,Gong M,Yu X

    更新日期:2011-04-01 00:00:00

  • No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity.

    abstract::AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 ge...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-012-9736-6

    authors: Beckers S,de Freitas F,Zegers D,Mertens IL,Verrijken A,Van Camp JK,Van Gaal LF,Van Hul W

    更新日期:2013-02-01 00:00:00

  • Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha.

    abstract::Steroid hormones regulate levels of gonadotropin mRNA in the pituitary, and gonadotropic hormones in plasma. To determine whether estrogen receptor alpha (ERalpha) mediates steroid negative feedback, wild type (WT) and estrogen receptor alpha knockout (ERalphaKO) mice of both sexes were gonadectomized and implanted wi...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:11:2:137

    authors: Wersinger SR,Haisenleder DJ,Lubahn DB,Rissman EF

    更新日期:1999-10-01 00:00:00

  • Correction to: Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Endocrine

    pub_type: 已发布勘误

    doi:10.1007/s12020-020-02514-y

    authors: Poli R,Scatolini M,Grosso E,Maletta F,Gallo M,Liscia D,Nelva A,Cesario F,Forte G,Metovic J,Volante M,Arvat E,Papotti M

    更新日期:2020-12-01 00:00:00

  • Effect of growth hormone and estrogen administration on hepatocyte alterations in old ovariectomized female wistar rats.

    abstract::Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/endo:26:1:011

    authors: Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

    更新日期:2005-02-01 00:00:00

  • Medullary thyroid carcinoma treated with percutaneous ultrasound-guided radiofrequency ablation.

    abstract:PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carc...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-019-01995-w

    authors: Biamonte E,Solbiati L,Ierace T,Colombo P,Lavezzi E,Mazziotti G,Lania A

    更新日期:2019-09-01 00:00:00

  • Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain.

    abstract::Cholecystokinin (CCK) amide concentrations were reduced over 85% in all the major brain regions of carboxypeptidase E (Cpe)(fat)/Cpe(fat) mice in comparison to control mice. Using an radioimmunoassay (RIA) specific for glycine-extended CCK (CCK Gly), low levels of CCK Gly were detected in control (0.65 ng/g tissue) an...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:9:3:329

    authors: Wang W,Cain BM,Beinfeld MC

    更新日期:1998-12-01 00:00:00

  • Reference values for handgrip strength in young people of both sexes.

    abstract::The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-012-9733-9

    authors: Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

    更新日期:2013-04-01 00:00:00

  • Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences.

    abstract:UNLABELLED:Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. OBJECTIVE:To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. SUBJECTS:Seventeen healthy overweight and obese subjects...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-008-9090-x

    authors: Araya AV,Orellana X,Espinoza J

    更新日期:2008-06-01 00:00:00

  • Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction.

    abstract::Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-020-02471-6

    authors: Deng W,Li Y,Ren Z,He Q,Jia Y,Liu Y,Zhang W,Gan X,Liu D

    更新日期:2020-12-01 00:00:00

  • Melatonin and Parkinson's disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnos...

    journal_title:Endocrine

    pub_type: 杂志文章,评审

    doi:10.1385/ENDO:27:2:169

    authors: Mayo JC,Sainz RM,Tan DX,Antolín I,Rodríguez C,Reiter RJ

    更新日期:2005-07-01 00:00:00

  • 68Ga-DOTANOC and 18F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers.

    abstract:OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-019-01846-8

    authors: Souteiro P,Gouveia P,Ferreira G,Belo S,Costa C,Carvalho D,Duarte H,Sampaio IL

    更新日期:2019-05-01 00:00:00

  • STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

    abstract:OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin ...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-017-1297-2

    authors: Gordon HM,Majithia N,MacDonald PE,Fox JEM,Sharma PR,Byrne FL,Hoehn KL,Evans-Molina C,Langman L,Brayman KL,Nunemaker CS

    更新日期:2017-06-01 00:00:00

  • True MEN1 or phenocopy? Evidence for geno-phenotypic correlations in MEN1 syndrome.

    abstract:PURPOSE:Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negative patients with MEN1-associated tumors represent phenocopies. By comparing mutation-positive and mut...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-019-01932-x

    authors: Kövesdi A,Tóth M,Butz H,Szücs N,Sármán B,Pusztai P,Tőke J,Reismann P,Fáklya M,Tóth G,Somogyi A,Borka K,Erdei A,Nagy EV,Deák V,Valkusz Z,Igaz P,Patócs A,Grolmusz VK

    更新日期:2019-08-01 00:00:00

  • Detection of serum p53 antibodies from Chinese patients with papillary thyroid carcinoma using phage-SP-ELISA: correlation with clinical parameters.

    abstract::The goal of the present study was to investigate whether p53 antibodies (Abs) could be a relevant marker for papillary thyroid carcinoma (PTC). Three types of enzyme-linked immunosorbent assay (ELISA) methods were developed for the detection of p53 Abs, including p53-ELISA, phage-SS-ELISA, and phage-SP-ELISA. A total ...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-014-0243-9

    authors: Pan P,Han X,Li F,Fu Q,Gao X,Sun H,Wang L

    更新日期:2014-11-01 00:00:00

  • Transforming growth factor-beta1 modulates chondrocyte responsiveness to 17beta-estradiol.

    abstract::This study examined the interrelationship between transforming growth factor-beta1 (TGF-beta1) and 17beta-estradiol (E2) in the regulation of growth plate chondrocytes. To determine whether TGF-beta1 modulates chondrocyte response to E2, we used cells isolated from the resting zone (RC) and growth zone (GC) of costoch...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:11:3:241

    authors: Nasatzky E,Grinfeld D,Boyan BD,Dean DD,Ornoy A,Schwartz Z

    更新日期:1999-12-01 00:00:00

  • Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells.

    abstract:PURPOSE:The influence of the dipeptidyl peptidase-IV inhibitor, gemigliptin alone or in combination with metformin on survival, proliferation, and migration of thyroid carcinoma cells was investigated. METHODS:SW1736 and TPC-1 human thyroid carcinoma cells were used. RESULTS:Gemigliptin and metformin caused cell deat...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-017-1503-2

    authors: Kim SH,Kang JG,Kim CS,Ihm SH,Choi MG,Yoo HJ,Lee SJ

    更新日期:2018-02-01 00:00:00

  • Secretion of inhibin and testicular expression of inhibin subunits in male duck embryos and newly hatched ducks.

    abstract::Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:28:2:171

    authors: Yang P,Medan MS,Arai KY,Jin W,Watanabe G,Taya K

    更新日期:2005-11-01 00:00:00

  • Exercise-induced nausea and vomiting: another sign and symptom of pheochromocytoma and paraganglioma.

    abstract::A cohort of nine patients, mostly young adults, presented with a new sign/symptom of pheochromocytoma/paraganglioma: exercise-induced nausea and vomiting. The aims of this article are to introduce this sign/symptom and offer a possible hypothesis for the observation. Following a 2000 report from a paraganglioma patien...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-010-9319-3

    authors: King KS,Darmani NA,Hughes MS,Adams KT,Pacak K

    更新日期:2010-06-01 00:00:00

  • Serum inhibin B for differentiating between congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty: a systematic review and meta-analysis.

    abstract:PURPOSE:The distinction between congenital hypogonadotropic hypogonadism (CHH) and constitutional delay of growth and puberty (CDGP) in patients with delayed puberty is difficult to distinguish, but important for timely treatment. The aim of this study is to perform a systematic review and meta-analysis to determine th...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-020-02582-0

    authors: Gao Y,Du Q,Liu L,Liao Z

    更新日期:2021-01-19 00:00:00

  • Genetic regulation of the embryology of the pituitary gland and somatotrophs.

    abstract::Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...

    journal_title:Endocrine

    pub_type: 杂志文章,评审

    doi:10.1385/ENDO:12:2:99

    authors: Cohen LE

    更新日期:2000-04-01 00:00:00

  • A transaldolase : An enzyme implicated in crab steroidogenesis.

    abstract::In arthropods, development is controlled by cholesterol-derived steroid hormones: the ecdysteroids. In vertebrates and insects, steroidogenesis is positively regulated and this is mediated by cAMP. In crustaceans, ecdysteroid biosynthesis by steroidogenic organs (Y-organs) is negatively regulated by a neuropeptide, th...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/BF02738652

    authors: Lachaise F,Sommé G,Carpentier G,Granjeon E,Webster S,Baghdassarian D

    更新日期:1996-08-01 00:00:00

  • The insulin resistance is reversed by exogenous 3,5,3'triiodothyronine in type 2 diabetic Goto-Kakizaki rats by an inflammatory-independent pathway.

    abstract:PURPOSE:Diabetes mellitus (DM) has a multifactorial etiology that imparts a particular challenge to effective pharmacotherapy. Thyroid hormone actions have demonstrated beneficial effects in diabetic as well as obese rats. In both conditions, inflammation status plays a crucial role in the development of insulin resist...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-020-02208-5

    authors: Panveloski-Costa AC,Kuwabara WMT,Munhoz AC,Lucena CF,Curi R,Carpinelli AR,Nunes MT

    更新日期:2020-05-01 00:00:00

  • Vasopressin, oxytocin, corticotrophin-releasing factor, and sodium responses during fluoxetine administration in the rat.

    abstract::Hyponatremia has been observed in elderly patients treated with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. The pathogenesis of this effect is not known, but enhanced release of vasopressin (VP) and its renal actions may be a possible mechanism. Excess secretion of VP in combination with large fluid ...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:8:1:13

    authors: Marar IE,Amico JA

    更新日期:1998-02-01 00:00:00

  • The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients.

    abstract:PURPOSE:Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relat...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-017-1307-4

    authors: Young Cho Y,Jeong Kim H,Won Jang H,Hyuk Kim T,Ki CS,Wook Kim S,Hoon Chung J

    更新日期:2017-07-01 00:00:00

  • Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas.

    abstract::Fibroadenomas are the most common benign breast tumors, occurring mainly in young women. Their responses to the hormonal environment are similar to those of normal breast tissue, which suggests that steroid receptors may play a role in tumor development. We evaluated the gene and protein expression of progesterone rec...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-009-9176-0

    authors: Branchini G,Schneider L,Cericatto R,Capp E,Brum IS

    更新日期:2009-06-01 00:00:00