Abstract:
PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carcinoma (MTC) who did not undergo surgery due to high anesthesiological risk. METHODS AND RESULTS:A 64-year-old woman was referred to our institution for a routine endocrinological visit. No thyroid-related symptoms were present. She had a history of metabolic, cardiovascular and neurological diseases. On clinical examination, a nodular lesion of about 10 mm was palpable in the right thyroid lobe; ultrasonography (US) confirmed the presence of a 13 mm thyroid nodule in the lower pole of the right lobe, that was hypoechoic and with regular margins. Serum calcitonin (Ctn) level was significantly high (647 pg/mL). Fine-needle aspiration (FNA) of the thyroid nodule was negative for malignant cells, but the marked increase of Ctn level in the FNA wash-out fluid confirmed the diagnostic suspicion of MTC. Since patient refused surgery due to high anesthesiological risk, percutaneous US-guided RFA in single session was performed. At 6-months follow-up the serum Ctn level decreased from the initial value of 647 pg/mL, reaching near-normal range (15 pg/mL), and neck ultrasound showed a complete necrosis of the tumour. Afterward, serum Ctn slowly increased to 49 pg/mL at 15-month follow-up. The US performed at 6 and 12 months of follow-up revealed fibrotic tissue in place of the thyroid nodule, without evidence of cervical lymph-node metastases. CONCLUSIONS:This clinical case suggests that RFA may be effective and safe for treatment of MTC when surgery cannot be performed.
journal_name
Endocrinejournal_title
Endocrineauthors
Biamonte E,Solbiati L,Ierace T,Colombo P,Lavezzi E,Mazziotti G,Lania Adoi
10.1007/s12020-019-01995-wsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
515-519issue
3eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-019-01995-wjournal_volume
65pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:21:2:159
更新日期:2003-07-01 00:00:00
abstract::The adipocyte-derived catabolic protein leptin alters cell-mediated immunity and cytokine crosstalk. This may provide new insights into the altered immune response, seen in obese individuals. Therefore, we determined the tissue distribution of immune cells in diet-induced obese (dio) and normal weight F344 rats challe...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9358-9
更新日期:2010-08-01 00:00:00
abstract::Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1020-8
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:This study was to perform a meta-analysis to assess the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal glucose metabolism. METHODS:The data sources were PubMed and EMBASE up to June 2018. Studies providing the relationship between HTW phenotype and abnormal glucose metabolism we...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-019-01945-6
更新日期:2019-06-01 00:00:00
abstract::Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with ve...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1078-3
更新日期:2016-11-01 00:00:00
abstract::Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9908-z
更新日期:2013-12-01 00:00:00
abstract::Hypopituitarism reduces life expectancy and increases the risk of cardiovascular and cerebrovascular diseases, as well as death. Abnormalities in the cardiovascular system may be independently related to GH deficiency (GHD). The aim of this study was to prospectively investigate coronary flow reserve and diastolic fun...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0951-4
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1297-2
更新日期:2017-06-01 00:00:00
abstract::Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/endo:26:3:259
更新日期:2005-04-01 00:00:00
abstract::Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations. Given that the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity and type 2 diabetes, we hypothesize that the common rs9939609 varia...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9257-0
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Data on the prevalence and type of endocrine disorders in β-thalassemia intermedia (β-TI) patients are scarce. This multicenter study was designed to determine the prevalence of endocrine complications and the associated risk factors in a large group of β-TI patients. METHODS:In this cross-sectional multice...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02159-6
更新日期:2020-07-01 00:00:00
abstract::Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9122-6
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:to assess bone damage and metabolic abnormalities in patients with Addison's disease given replacement doses of glucocorticoids and mineralocorticoids. METHODS:A total of 87 patients and 81 age-matched and sex-matched healthy controls were studied. The following parameters were measured: urinary cortisol, seru...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1380-8
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:This study investigated trends in chronic glucocorticoid (GC) use in South Korea, and determined the association between chronic GC use and 5-year all-cause mortality. METHODS:A sample cohort was extracted from the South Korean National Health Insurance database. Patients prescribed a continuous dose of GC for...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02382-6
更新日期:2020-09-01 00:00:00
abstract::Pituitary tumors are highly vascular neoplasms, which suggest an important role of angiogenesis in pituitary tumor growth. We used the human pituitary cell line (HP75) to examine the effects of the growth factors TGFbeta1, bFGF, and EGF on cell growth, and on the regulation of the pro-angiogenic growth factor VEGF-A a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:2:141
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01970-5
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:Insulin resistance is an important factor in the pathogenesis of polycystic ovary syndrome (PCOS), which is associated with higher risk of metabolic syndrome (MetS) and cardiovascular complications. Early atherosclerotic lesions may be diagnosed by ultrasonographic parameters: brachial artery flow-mediated dila...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02596-8
更新日期:2021-01-13 00:00:00
abstract::Chronic ethanol exposure causes alterations in biologic membranes of different cell types. (Na + K) adenosine triphosphatase (ATPase), a membrane-bound enzyme inhibited by the acute presence of ethanol, increases its activity in rat kidney after chronic ethanol consumption. The aim of this investigation was to evaluat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:19:3:301
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:Recently, it has been confirmed that circulating miRNAs play an important role in disease pathogenesis and can be biomarkers of many autoimmune diseases. However, the knowledge about circulating miRNAs in Graves' disease (GD) is very limited. In this study, we aimed to identify circulating miRNAs as potential b...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01884-2
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyro...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01913-0
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate the serum level of zonulin, which is an intestinal permeability (IP) biomarker, in primary hyperparathyroidism (PHPT) and to investigate the relationship between zonulin, calcium, and parathormone (PTH) levels. METHODS:The study included 34 healthy control (HC) and 39 patients with PHPT. Serum calc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02504-0
更新日期:2020-09-28 00:00:00
abstract::Fibroadenomas are the most common benign breast tumors, occurring mainly in young women. Their responses to the hormonal environment are similar to those of normal breast tissue, which suggests that steroid receptors may play a role in tumor development. We evaluated the gene and protein expression of progesterone rec...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9176-0
更新日期:2009-06-01 00:00:00
abstract::To explore the regulation of follistatin gene expression, porcine granulosa cells were incubated with the translational inhibitor, cycloheximide (CHX), for periods from 6-24 h. This resulted in a 3 to 10-fold increase in follistatin mRNA accumulation compared to vehicle treated control cultures. At 20 h, CHX augmented...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02953027
更新日期:1995-08-01 00:00:00
abstract::Steroidogenic factor-1 (SF-1) is a transcription factor involved in regulation of steroidogenic enzymes. Recent evidence indicates that SF-1 is also important in the anterior pituitary gland, where it may influence gene expression in gonadotropes. We isolated a cDNA encoding ovine SF-1 and demonstrated that the SF-1 g...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02820500
更新日期:1997-06-01 00:00:00
abstract::The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1069-4
更新日期:2017-01-01 00:00:00
abstract::Ames dwarf mice have primary deficiency of prolactin (PRL), growth hormone (GH), and thyroid-stimulating hormone (TSH), and live considerably longer than normal animals from the same line. In view of the documented effects of GH, PRL, and thyroid hormones on lean and fat body mass and skeletal growth, and the suspecte...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:1-2:149
更新日期:2003-02-01 00:00:00
abstract::Growth hormone (GH) and prolactin share similarities in structure and function. We have previously shown that women with congenital isolated GH deficiency (IGHD) caused by a homozygous mutation in the GHRH receptor gene (GHRHR) (MUT/MUT) have a short reproductive life, with anticipated climacteric. At climacteric, the...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9896-z
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Non-functioning pituitary adenomas (NFPA) have a substantial impact on patients' health status, yet research on the extent of healthcare utilization and costs among these patients is scarce. The objective was to determine healthcare usage, associated costs, and their determinants among patients treated for an N...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01847-7
更新日期:2019-05-01 00:00:00
abstract::Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02471-6
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:To prepare for radioactive iodine therapy in post total thyroidectomy patients with well-differentiated thyroid cancer (WDTC), either thyroid hormone withdrawal (THW) or administration of recombinant human thyrotropin (rhTSH) can be performed. OBJECTIVE:Our objective is to compare quality of life (QoL) paramet...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02238-z
更新日期:2020-07-01 00:00:00