Abstract:
:In arthropods, development is controlled by cholesterol-derived steroid hormones: the ecdysteroids. In vertebrates and insects, steroidogenesis is positively regulated and this is mediated by cAMP. In crustaceans, ecdysteroid biosynthesis by steroidogenic organs (Y-organs) is negatively regulated by a neuropeptide, the Molt Inhibiting Hormone (MIH). This neuropeptide-induced inhibition occurs via cyclic nucleotides and depends on protein synthesis. In the present work, we provide evidence that a major 36.2-kDa cytosolic protein (P36; pl: 6.8) from crab Y-organs is positively correlated with steroidogenic activity. On the basis of its amino acid sequence, P36 could be related to transaldolase, an enzyme of the pentose phosphate pathway which generates NADPH. In Y-organs, the enzymatic activity ofCarcinus transaldolase increases with steroidogenic activity, and MIH treatment decreases both synthesis and activity of transaldolase. Various transaldolases have been characterized in very distantly related groups, namely bacteria, yeasts, and humans. These enzymes are highly conserved and present strong structural homologies, interestingly the crab transaldolase is closest to that enzyme characterized in human cells.
journal_name
Endocrinejournal_title
Endocrineauthors
Lachaise F,Sommé G,Carpentier G,Granjeon E,Webster S,Baghdassarian Ddoi
10.1007/BF02738652subject
Has Abstractpub_date
1996-08-01 00:00:00pages
23-32issue
1eissn
1355-008Xissn
1559-0100journal_volume
5pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:3:279
更新日期:2002-08-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Endocrine
pub_type: 已发布勘误
doi:10.1007/s12020-020-02514-y
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-anal...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-017-1444-9
更新日期:2018-01-01 00:00:00
abstract::Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9372-y
更新日期:2010-10-01 00:00:00
abstract::RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9614-2
更新日期:2012-08-01 00:00:00
abstract::In this study, we investigated gingival enlargement in patients with acromegaly as a component of the disease. Eleven patients (5 males, 6 females) were evaluated. Diagnosis was confirmed with typical clinical features and laboratory. Oral examinations were carried out by the same periodontist. During the examination,...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:3:207
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Conformal, fractionated radiation therapy (XRT) is variably used as a treatment alternative for active acromegaly patients, usually, after failed pituitary surgery. Our objective was to evaluate the long-term efficacy and safety of XRT using strict criteria of biochemical control. SETTING, DESIG...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01955-4
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved. METHODS:The patient group comprised 200 children with CHI that were treated at the Beijing Children's Hospital from January 2006 to December 2018. Th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02585-x
更新日期:2021-01-27 00:00:00
abstract::Peptide hormones are generated by proteolytic processing of their respective protein precursors by several prohormone processing proteases. The peptide hormone PTHrP is widely expressed in normal and malignant tissues, where proPTHrP undergoes proteolytic processing to generate PTHrP peptides with distinct biological ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:15:2:217
更新日期:2001-07-01 00:00:00
abstract::The present study was designed to determine whether an association exists between HPA activity and cytokine production in major depression (MD). In 9 patients with MD and 11 control subjects of both sexes, all drug-free, activity of the HPA axis was evaluated by circadian rhythm of plasma cortisol, 24-h free urinary c...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-006-0016-1
更新日期:2006-12-01 00:00:00
abstract::Phex is the gene whose mutation is the cause of X-linked hypophosphatemia in humans and mice. The organs expressing Phex in normal animals, and their possible sensitivity to stimulation by low phosphate diets, are unknown. In this study, Phex expression was measured in 6-wk-old normal B6C3H male and female mice and in...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:1:81
更新日期:2000-08-01 00:00:00
abstract::Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0038-4
更新日期:2014-05-01 00:00:00
abstract::Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:26:1:011
更新日期:2005-02-01 00:00:00
abstract::Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with ve...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1078-3
更新日期:2016-11-01 00:00:00
abstract::The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-013-9985-z
更新日期:2014-03-01 00:00:00
abstract::Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9389-2
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating N...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02164-9
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Low mineral mass and reduced bone strength with increased fracture risk are the main causes of morbidity in Thalassemia Major (TM). The pathogenesis is multifactorial and includes ineffective erythropoiesis with medullary expansion, multiple endocrine dysfunctions, direct iron bone deposition, deferoxamine-i...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-019-02003-x
更新日期:2019-09-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinica...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0408-6
更新日期:2015-04-01 00:00:00
abstract::The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D-deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0693-8
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of mi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1551-2
更新日期:2018-05-01 00:00:00
abstract::Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02782760
更新日期:1996-04-01 00:00:00
abstract::Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0089-6
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:A recent report described a new PCOS-like phenotype in lean older infertile women, and was characterized by high age-specific anti-Müllerian hormone (AMH) but hypo- rather than the expected hyper-androgenism. The hypo-androgenism was, furthermore, characterized of, likely, adrenal origin and autoimmune etiol...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1498-8
更新日期:2018-03-01 00:00:00
abstract::Recently, an endogenous ligand has been described for the growth hormone secretagogue receptor (GHS-R), named ghrelin. It was originally isolated from the stomach, but it is also present in the hypothalamus, where the highest concentration of GHS-R has been detected. It is well established that synthetic GHSs exert th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:14:1:101
更新日期:2001-02-01 00:00:00
abstract::The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorph...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0218-x
更新日期:2015-02-01 00:00:00
abstract::Mineralocorticoid and glucocorticoid hormones activate the expression of the Na/K ATPase beta1 through direct binding of the mineralocorticoid receptor (MR) and glucocorticoid receptors (GR) to a mineralocorticoid- and glucocorticoid-responsive element in the beta1 promoter region, but activation of the beta1 promoter...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:3:287
更新日期:2000-12-01 00:00:00
abstract::To assess how early can estrogens induce female mating behaviors, rat pups 8-29 days old (D8-D29, respectively) were injected twice daily with estradiol benzoate (E) or oil (O) followed by progesterone (P) or oil, and then observed for the estrogen-dependent ear wiggling (EW) and lordosis in response to natural stimul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9046-1
更新日期:2007-12-01 00:00:00
abstract::Chronic ethanol exposure causes alterations in biologic membranes of different cell types. (Na + K) adenosine triphosphatase (ATPase), a membrane-bound enzyme inhibited by the acute presence of ethanol, increases its activity in rat kidney after chronic ethanol consumption. The aim of this investigation was to evaluat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:19:3:301
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION AND AIM:Hyperprolactinaemia in pregnancy leads to mild and reversible changes in the maternal skeletal system, and medicamentous hyperprolactinemia causes more detrimental effects. We conducted an experimental study to evaluate differences between Prlr gene expression in the duodenum, vertebrae and kidneys...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1730-1
更新日期:2018-12-01 00:00:00