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Verification of candidate microRNA markers for parathyroid carcinoma.

Abstract：

PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. METHODS:A total of 58 tissue samples, including 17 PCa lesions and 41 sporadic parathyroid adenomas (PAds), were obtained from 56 primary hyperparathyroidism (pHPT) patients. Candidate miRNAs (miR-139-5p, miR-155-5p, miR-222-3p, miR-26b-5p, miR-296-5p, miR-30b-5p, miR-372-3p, miR-503-5p, miR-517c-3p, miR-7-5p, and miR-126-5p) were quantified by TaqMan real-time quantitative PCR assays. RESULTS:Up-regulated miR-222 (p = 0.041) levels and down-regulated miR-139 (p = 0.003), miR-30b (p < 0.001), miR-517c (p = 0.038), and miR-126* (p = 0.002) levels were found in PCa relative to PAd. Binary logistic regression analysis showed that miR-139 and miR-30b were the best diagnostic markers. The combination of miR-139 and miR-30b yielded an area under the receiver operating characteristic curve of 0.888. Additionally, serum calcium (r s  = -0.518, p < 0.001), intact parathyroid hormone (iPTH) (r s  = -0.495, p < 0.001), and alkaline phosphatase (ALP) (r s  = -0.523, p < 0.001) levels were negatively correlated with miR-30b levels. CONCLUSIONS:miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd. The combined analysis of miR-139 and miR-30b may be used as a potential diagnostic strategy for distinguishing PCa from PAd.

journal_name

Endocrine

journal_title

Endocrine

authors

Hu Y,Zhang X,Cui M,Su Z,Wang M,Liao Q,Zhao Y

doi

10.1007/s12020-018-1551-2

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

246-254

issue

2

eissn

1355-008X

issn

1559-0100

pii

10.1007/s12020-018-1551-2

journal_volume

60

pub_type

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