Abstract:
:A cohort of nine patients, mostly young adults, presented with a new sign/symptom of pheochromocytoma/paraganglioma: exercise-induced nausea and vomiting. The aims of this article are to introduce this sign/symptom and offer a possible hypothesis for the observation. Following a 2000 report from a paraganglioma patient experiencing exercise-induced nausea and vomiting, we began asking patients about instances of nausea and vomiting with exercise. A total of nine patients, 4.4% of our pheochromocytoma/paraganglioma population, presented with reports of exercise-induced nausea and vomiting, initially with moderate-to-intense levels of exercise, at the first presentation of their disease. All of these patients reported a cessation of exercise-induced nausea and vomiting following the removal of their primary tumor. Two patients with metastatic disease to the lungs reported a recurrence of exercise-induced nausea and vomiting. The majority of patients studied were young adults with mean onset age of 19.4 years (range of 9-51 years) and the mean age of diagnosis being 24.1 years (range of 11-53 years). Exercise-induced nausea and vomiting should be considered a sign/symptom of pheochromocytoma/paraganglioma and should be addressed in the clinical evaluation of these patients, especially in young adults. Whether exercise-induced elevated catecholamine levels could account for the induced nausea and vomiting via activation of adrenergic receptors in the area postrema remains to be established.
journal_name
Endocrinejournal_title
Endocrineauthors
King KS,Darmani NA,Hughes MS,Adams KT,Pacak Kdoi
10.1007/s12020-010-9319-3subject
Has Abstractpub_date
2010-06-01 00:00:00pages
403-7issue
3eissn
1355-008Xissn
1559-0100journal_volume
37pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated in Parkinson's disease patients treated with dopamine agonists. Retrospective studies in prolactinoma patients tre...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1120-5
更新日期:2017-01-01 00:00:00
abstract::Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:26:1:011
更新日期:2005-02-01 00:00:00
abstract:UNLABELLED:Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. A...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-012-9631-1
更新日期:2012-08-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life. The aim of this study was to investigate uptake of deoxy-D-glucose by peripheral blood lymphocytes of PCOS patients with normal fasting plasma glucose and normal glucose tolerance test. The...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0174-5
更新日期:2014-11-01 00:00:00
abstract::We aimed to investigate different enhancement patterns of solid thyroid nodules on contrast-enhanced ultrasound (CEUS) and then to evaluate the corresponding diagnostic performance in the differentiation of benign and malignant nodules with and without enhancement. 229 solid thyroid nodules in 196 patients who had und...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0850-0
更新日期:2016-08-01 00:00:00
abstract::Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-016-1038-y
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01970-5
更新日期:2019-07-01 00:00:00
abstract::Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:2:163
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1742-x
更新日期:2018-12-01 00:00:00
abstract::We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0044-5
更新日期:2007-06-01 00:00:00
abstract::Persistent hyperglycemia is associated with chronic oxidative stress which contributes to the development and progression of diabetes-associated complications. The sensitivity of pancreatic β-cells to oxidative stress has been attributed to their low content of antioxidants compared with other tissues. Bioactive compo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9866-x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compar...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1468-1
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Acute porphyrias are metabolic disorders of heme biosynthesis characterized by acute life-threatening attacks. The diagnosis is often missed since clinical presentation is aspecific mimicking other medical and surgical conditions. Variegate porphyria (VP) is an autosomal dominant inherited disease with incomple...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1569-5
更新日期:2018-09-01 00:00:00
abstract::Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:30:1:121
更新日期:2006-08-01 00:00:00
abstract::The main objective of this article is to study the psychosocial profile of patients of Cushing disease (CD) in a developing country setting. Eighteen patients with CD underwent a cross-sectional assessment regarding their socio-demographic and clinical profile, life events, social support, coping, dysfunction, quality...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9182-2
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Various studies in placental tissue suggest that diabetes mellitus alters the expression of glucose transporter (GLUT) proteins, with insulin therapy being a possible modulatory factor. The aim of the present study was quantitative evaluation of the expression of glucose transporters (GLUT-1, GLUT-4, GLUT-9) in...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1202-4
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:This study investigated trends in chronic glucocorticoid (GC) use in South Korea, and determined the association between chronic GC use and 5-year all-cause mortality. METHODS:A sample cohort was extracted from the South Korean National Health Insurance database. Patients prescribed a continuous dose of GC for...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02382-6
更新日期:2020-09-01 00:00:00
abstract::Mammary cell mitogenic responsiveness was evaluated with an established nontransformed caprine mammary epithelial cell line (CMEC). As expected, the cells responded to insulin-like growth factor 1 (IGF-1), insulin, and hydrocortisone with an increased number of cells after 3 and 5 d in culture. In combination, insulin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:10:2:123
更新日期:1999-04-01 00:00:00
abstract:CONTEXT:Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION:We present a three-generation family with 5 affected memb...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1497-9
更新日期:2018-03-01 00:00:00
abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:Changes in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The main aim of this study were to evaluate changes in body composition and the prevalence of pre-sarcopenia and sarcopenia in patients with COPD, compared with two control groups and correlate these parameters wit...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1533-4
更新日期:2018-04-01 00:00:00
abstract::Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from indi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:29:1:27
更新日期:2006-02-01 00:00:00
abstract::Ames dwarf mice have primary deficiency of prolactin (PRL), growth hormone (GH), and thyroid-stimulating hormone (TSH), and live considerably longer than normal animals from the same line. In view of the documented effects of GH, PRL, and thyroid hormones on lean and fat body mass and skeletal growth, and the suspecte...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:1-2:149
更新日期:2003-02-01 00:00:00
abstract:UNLABELLED:Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. OBJECTIVE:To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. SUBJECTS:Seventeen healthy overweight and obese subjects...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9090-x
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. METHODS:Patients admitted for glioma and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02016-6
更新日期:2019-12-01 00:00:00
abstract::Chronic ethanol exposure causes alterations in biologic membranes of different cell types. (Na + K) adenosine triphosphatase (ATPase), a membrane-bound enzyme inhibited by the acute presence of ethanol, increases its activity in rat kidney after chronic ethanol consumption. The aim of this investigation was to evaluat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:19:3:301
更新日期:2002-12-01 00:00:00
abstract::Despite the availability of many new treatment options for type 2 diabetes, the proportion of patients achieving the HbA1c target < 7.0% remains around 50%. We put forward the hypothesis that the unchanged HbA1c results, observed in the last decade in type 2 diabetes patients, are also a consequence of medication nona...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-017-1517-9
更新日期:2018-07-01 00:00:00
abstract::Factors affecting longevity are complex and poorly understood. We have recently found that Ames dwarf mice (df/df), which are deficient in growth hormone (GH), prolactin, and thyroid-stimulating hormone, live significantly longer than their normal siblings whereas transgenic mice that overexpress GH exhibit reduced li...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:11:1:41
更新日期:1999-08-01 00:00:00
abstract::Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with ve...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1078-3
更新日期:2016-11-01 00:00:00
abstract::Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738705
更新日期:1996-10-01 00:00:00