Abstract:
:Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficult occurring even in patients with normal bone mineral density. In this study we evaluated the ability of high-resolution cone-beam computed tomography to provide information on skeletal abnormalities associated with vertebral fractures in acromegaly. 40 patients (24 females, 16 males; median age 57 years, range 25-72) and 21 healthy volunteers (10 females, 11 males; median age 60 years, range: 25-68) were evaluated for trabecular (bone volume/trabecular volume ratio, mean trabecular separation, and mean trabecular thickness) and cortical (thickness and porosity) parameters at distal radius using a high-resolution cone-beam computed tomography system. All acromegaly patients were evaluated for morphometric vertebral fractures and for mineral bone density by dual-energy X-ray absorptiometry at lumbar spine, total hip, femoral neck, and distal radius. Acromegaly patients with vertebral fractures (15 cases) had significantly (p < 0.05) lower bone volume/trabecular volume ratio, greater mean trabecular separation, and higher cortical porosity vs. nonfractured patients, without statistically significant differences in mean trabecular thickness and cortical thickness. Fractured and nonfractured acromegaly patients did not have significant differences in bone density at either skeletal site. Patients with acromegaly showed lower bone volume/trabecular volume ratio (p = 0.003) and mean trabecular thickness (p < 0.001) and greater mean trabecular separation (p = 0.02) as compared to control subjects, without significant differences in cortical thickness and porosity. This study shows for the first time that abnormalities of bone microstructure are associated with radiological vertebral fractures in acromegaly. High-resolution cone-beam computed tomography at the distal radius may be useful to evaluate and predict the effects of acromegaly on bone microstructure.
journal_name
Endocrinejournal_title
Endocrineauthors
Maffezzoni F,Maddalo M,Frara S,Mezzone M,Zorza I,Baruffaldi F,Doglietto F,Mazziotti G,Maroldi R,Giustina Adoi
10.1007/s12020-016-1078-3subject
Has Abstractpub_date
2016-11-01 00:00:00pages
532-542issue
2eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-016-1078-3journal_volume
54pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:2:163
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01846-8
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein sub...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1241-5
更新日期:2017-03-01 00:00:00
abstract::Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9809-6
更新日期:2013-06-01 00:00:00
abstract::Ascorbate is a reducing agent, which is also known to oxidize cellular components. Our proposed mechanism of the oxidative action is as follows: Ascorbate is concentrated in the pancreas and is leaked in adverse conditions, and oxidized to dehydroascorbate. The dehydroascorbate is carried into cells by a glucose trans...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:1:91
更新日期:2002-06-01 00:00:00
abstract::The adipocyte-derived catabolic protein leptin alters cell-mediated immunity and cytokine crosstalk. This may provide new insights into the altered immune response, seen in obese individuals. Therefore, we determined the tissue distribution of immune cells in diet-induced obese (dio) and normal weight F344 rats challe...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9358-9
更新日期:2010-08-01 00:00:00
abstract::Previous evidence supports the view that insulin, as well as insulin like growth factor-1 (IGF-1) provides neurotropic support for neurons in the central nervous system (CNS) and peripheral nervous system (PNS). In the present study we evaluated the effects of the intravenous infusion of IGF-1 on both necrosis and apo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0012-0
更新日期:2007-02-01 00:00:00
abstract::Graves' disease (GD) and Hashimoto's thyroiditis (HT) are both common autoimmune diseases of the thyroid gland (AITD). The IL-4 is involved in both humoral and cellular immunity. The aim of this study was to test whether the IL-4 gene could be used as a genetic marker to predict the development of AITD amongst the Chi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-9027-9
更新日期:2007-10-01 00:00:00
abstract::Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9842-5
更新日期:2013-08-01 00:00:00
abstract::Prolactinomas are the most common secretory pituitary tumors; however, their pathogenesis is unclear. In order to explore the pathogenesis of prolactinomas, we used fiber-optic BeadArray to examine gene expression profiles in five prolactinomas compared with three normal pituitaries. Three down-regulated genes and one...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9389-2
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:The early-life nutritional environment affects long-term glucose homeostasis, we investigated the effects of maternal low-protein diet combined with postnatal early overfeeding on the male offspring's glucose homeostasis in adulthood. METHODS:Only male rats were used, and their delivery was considered postnata...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1719-9
更新日期:2019-01-01 00:00:00
abstract::RU486 has been reported to be a glucocorticoid receptor (GR) and a progesterone receptor (PR) antagonist. We have analysed RU486 activity on the GR in WCL-2 (CHO) cells and in COS-7 cells transiently transfected with the mouse GR and with the reporter MMTVCAT (MCAT). These cell lines do not contain any active progeste...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02917442
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Risk of cardiovascular disease (CVD) is increased in Graves' disease (GD). CVD is predicted by increased pulse wave velocity (PWV) and blood pressure (BP). GD and these risk factors are all associated with lower levels of vitamin D. We aimed to assess the effect of supplemental vitamin D on PWV and BP in GD. M...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01997-8
更新日期:2019-11-01 00:00:00
abstract::Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0089-6
更新日期:2014-08-01 00:00:00
abstract::Despite the availability of many new treatment options for type 2 diabetes, the proportion of patients achieving the HbA1c target < 7.0% remains around 50%. We put forward the hypothesis that the unchanged HbA1c results, observed in the last decade in type 2 diabetes patients, are also a consequence of medication nona...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-017-1517-9
更新日期:2018-07-01 00:00:00
abstract::Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9472-3
更新日期:2011-10-01 00:00:00
abstract::Our aim was to evaluate the effectiveness of off-label use of sunitinib in patients with advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAI) therapy. We performed a retrospective analysis of patients treated in the setting of clinical practice in a University General Hospital. Eleven...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0356-1
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1742-x
更新日期:2018-12-01 00:00:00
abstract::Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738705
更新日期:1996-10-01 00:00:00
abstract::Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. This can be caused by stabilizing mutation of β-catenin (CTNNB1, exon 3) or by mutation or deregulated expression of other components of the WNT/β-catenin signaling pathway. Accumulation of non-phosphorylated active β-catenin h...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9690-3
更新日期:2012-12-01 00:00:00
abstract::Patients with ectopic ACTH syndrome often develop hypertension and hypokalemic alkalosis with an abnormal increase in the ratio of plasma cortisol to cortisone, indicating that 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) activity is inhibited. Inhibition of 11 beta HSD allows access of cortisol or corticosteron...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02801327
更新日期:1997-12-01 00:00:00
abstract::Circadian rhythmicity is affected in obese subjects. This article analyzes the effect of a high-fat diet (35% fat) on 24-h changes circulating prolactin, luteinizing hormone (LH), testosterone, corticosterone, thyroid-stimulating hormone (TSH) and glucose, and pineal melatonin content, in rats. When body weight of rat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9066-x
更新日期:2008-04-01 00:00:00
abstract::Persistent hyperglycemia is associated with chronic oxidative stress which contributes to the development and progression of diabetes-associated complications. The sensitivity of pancreatic β-cells to oxidative stress has been attributed to their low content of antioxidants compared with other tissues. Bioactive compo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9866-x
更新日期:2013-10-01 00:00:00
abstract::This study examined the interrelationship between transforming growth factor-beta1 (TGF-beta1) and 17beta-estradiol (E2) in the regulation of growth plate chondrocytes. To determine whether TGF-beta1 modulates chondrocyte response to E2, we used cells isolated from the resting zone (RC) and growth zone (GC) of costoch...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:11:3:241
更新日期:1999-12-01 00:00:00
abstract::Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:29:2:341
更新日期:2006-04-01 00:00:00
abstract::The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-013-9985-z
更新日期:2014-03-01 00:00:00
abstract::The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the pharmacologic properties of the human A1AR, examined somatic sites of A1AR gene expression, and identified the chromosomal location of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02746338
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:This study was to perform a meta-analysis to assess the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal glucose metabolism. METHODS:The data sources were PubMed and EMBASE up to June 2018. Studies providing the relationship between HTW phenotype and abnormal glucose metabolism we...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-019-01945-6
更新日期:2019-06-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Endocrine
pub_type: 已发布勘误
doi:10.1007/s12020-020-02514-y
更新日期:2020-12-01 00:00:00
abstract::Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0196-z
更新日期:2014-11-01 00:00:00