Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia.

Abstract:

:Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of the adipokines adiponectin and/or resistin are altered during hypoxia and/or dexamethasone therapy in neonatal rats. Rat pups with their lactating dams were exposed to hypoxia (11% O2) from birth and treated with a tapering regimen of dexamethasone from postnatal day (PD) 3-6. Serum adiponectin and resistin were measured on PD7. Hypoxia and dexamethasone independently decreased body weight gain and increased adiponectin levels. The combination of hypoxia and dexamethasone did not further increase adiponectin. Dexamethasone caused a small increase in resistin in normoxic pups, which may facilitate the hyperinsulemic- normoglycemic state we previously described. We also conclude that adiponectin is increased during hypoxia in response to a decrease in the sensitivity to insulin.

journal_name

Endocrine

journal_title

Endocrine

authors

Raff H,Bruder ED

doi

10.1385/ENDO:29:2:341

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

341-4

issue

2

eissn

1355-008X

issn

1559-0100

pii

ENDO:29:2:341

journal_volume

29

pub_type

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