Abstract：
INTRODUCTION:Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. MATERIAL AND METHODS:Serum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey hypophysis and hypothalamus slides, serum cytokines though an array membrane and cell-mediated immunity though the white blood cells count. RESULTS:Nineteen PAH cases entered the study. APA or AHA were identified in all cases. APA were detected in 13 patients (68.4%) and AHA in 13 patients (68.4%). Ten patients (52.6%) were simultaneously positive for both APA and AHA. The prevalence of APAs and AHAs was higher as compared to those observed in 50 health controls (respectively 14% p < 0.001 and 24% p = 0.004) and in 100 not-secreting pituitary adenoma (NFPAs) (respectively 22% p = 0.002 and 8% p < 0.001). Similarly, the prevalence of simultaneous positivity for APA and AHA (52.9%) was higher as compared to the those detected in patients affected by NFPAs (0%; p < 0.001) and in health controls (16% p = 0.002). No differences were identified between PAHs and controls at qualitative and quantitative analysis of serum cytokines and white blood cells count. CONCLUSIONS:This study suggest that APA and AHA may be detected in an high percentage of PAH cases and that their simultaneous identification may be useful for the differential diagnosis between PAH and NFPAs, in an appropriate clinical context.
journal_name
Endocrinejournal_title
Endocrineauthors
Chiloiro S,Giampietro A,Angelini F,Arena V,Stigliano E,Tartaglione T,Mattogno PP,D'Alessandris QG,Lauretti L,Pontecorvi A,De Marinis L,Bianchi Adoi
10.1007/s12020-021-02612-5subject
Has Abstractpub_date
2021-01-23 00:00:00eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-021-02612-5pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract：:Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775)...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-016-1096-1
更新日期：2017-01-01 00:00:00
abstract：:The therapeutic activity of 131I administered to patients with Graves' disease can be calculated by means of Marinelli's formula. The thyroidal iodine uptake (131IUmax) needed for the calculation is usually determined with the use of 131I. The purpose of the paper was to estimate 131IUmax on the basis of technetium up...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-016-1074-7
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relat...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-017-1307-4
更新日期：2017-07-01 00:00:00
abstract：:A cohort of nine patients, mostly young adults, presented with a new sign/symptom of pheochromocytoma/paraganglioma: exercise-induced nausea and vomiting. The aims of this article are to introduce this sign/symptom and offer a possible hypothesis for the observation. Following a 2000 report from a paraganglioma patien...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-010-9319-3
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND AND AIM:A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in overweight subjects is still a matter of concern. We studied free cortisol (urinary free cortiso...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-020-02392-4
更新日期：2020-08-01 00:00:00
abstract：:PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease ...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1007/s12020-014-0440-6
更新日期：2015-05-01 00:00:00
abstract：:Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:9:2:163
更新日期：1998-10-01 00:00:00
abstract：PURPOSE:Changes in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The main aim of this study were to evaluate changes in body composition and the prevalence of pre-sarcopenia and sarcopenia in patients with COPD, compared with two control groups and correlate these parameters wit...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1533-4
更新日期：2018-04-01 00:00:00
abstract：:Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the eff...
journal_title：Endocrine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12020-009-9157-3
更新日期：2009-06-01 00:00:00
abstract：:A great number of prospective studies have investigated the relationship between leisure time physical activity (LTPA) and metabolic syndrome (MetS) risk. However, the results have been inconsistent. The aim of this study was to clarify the relationship between LTPA and MetS risk. Literature databases were searched in...
journal_title：Endocrine
pub_type： 杂志文章,meta分析
doi：10.1007/s12020-013-0110-0
更新日期：2014-06-01 00:00:00
abstract：:Variants of growth hormone (GH) are present in most vertebrates. Chicken GH (cGH) undergoes posttranslational modifications that contribute to its structural diversity. Although the 22-kDa form of GH is the most abundant, some other variants have discrete bioactivities that may not be shared by others. The proportion ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:17:2:91
更新日期：2002-03-01 00:00:00
abstract：:The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-009-9178-y
更新日期：2009-06-01 00:00:00
abstract：:Multiple lines of evidence have implicated the growth hormone (GH) axis in the regulation of erythropoiesis. To test the hypothesis that GH deficiency is associated with hematologic abnormalities, we analyzed pretreatment hemoglobin levels in 100 children with GH deficiency. Hemoglobin levels were decreased in childre...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:18:2:135
更新日期：2002-07-01 00:00:00
abstract：:Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-012-9842-5
更新日期：2013-08-01 00:00:00
abstract：:Recently, an endogenous ligand has been described for the growth hormone secretagogue receptor (GHS-R), named ghrelin. It was originally isolated from the stomach, but it is also present in the hypothalamus, where the highest concentration of GHS-R has been detected. It is well established that synthetic GHSs exert th...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:14:1:101
更新日期：2001-02-01 00:00:00
abstract：:The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-016-1069-4
更新日期：2017-01-01 00:00:00
abstract：:Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:25:3:229
更新日期：2004-12-01 00:00:00
abstract：:Various factors influence quality of life (QoL) in acromegaly. Whether disease control and treatment approach are related to QoL is still a matter of debate. The aim of the present study was to evaluate QoL in patients with acromegaly using the disease-specific Acromegaly Quality of Life Questionnaire in respect to di...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0521-6
更新日期：2015-08-01 00:00:00
abstract：:We performed this study to investigate the prevalences of insulin resistance and metabolic syndrome (MetS) in a Chinese population with normal weight. We also examined whether fat mass is associated with insulin resistance and MetS in normal-weight individuals. Data were drawn from a cross-sectional study in China. Su...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-013-0079-8
更新日期：2014-08-01 00:00:00
abstract：:Diabetes with hypertension is characterized by increased cerebrovascular pathology and poorer outcomes following stroke. In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine. Normal and dia...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:25:2:091
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:Acute porphyrias are metabolic disorders of heme biosynthesis characterized by acute life-threatening attacks. The diagnosis is often missed since clinical presentation is aspecific mimicking other medical and surgical conditions. Variegate porphyria (VP) is an autosomal dominant inherited disease with incomple...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1569-5
更新日期：2018-09-01 00:00:00
abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02738705
更新日期：1996-10-01 00:00:00
abstract：:RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-012-9614-2
更新日期：2012-08-01 00:00:00
abstract：:The aim of the study was to assess the impact of sex hormone-binding globulin (SHBG) on bone mineral density (BMD) and bone turnover among Chinese middle-aged and elderly men. This cross-sectional study was carried out among 404 Chinese men aged over 45 years. BMD was measured with dual-energy X-ray absorptiometry, an...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-013-0155-0
更新日期：2014-11-01 00:00:00
abstract：CONTEXT:To prepare for radioactive iodine therapy in post total thyroidectomy patients with well-differentiated thyroid cancer (WDTC), either thyroid hormone withdrawal (THW) or administration of recombinant human thyrotropin (rhTSH) can be performed. OBJECTIVE:Our objective is to compare quality of life (QoL) paramet...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-020-02238-z
更新日期：2020-07-01 00:00:00
abstract：:Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations. Given that the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity and type 2 diabetes, we hypothesize that the common rs9939609 varia...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-009-9257-0
更新日期：2009-12-01 00:00:00
abstract：:The objectives of this study were to analyse the results of surgical treatment of multinodular goiter (MG) in a population with under 30 yr of age; (2) to determine the incidence and evolution of related thyroid carcinomas; and (3) to evaluate the rate of relapse. Eighty-one patients operated for MG and under 30 yr of...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:27:3:245
更新日期：2005-08-01 00:00:00
abstract：:To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:15:1:079
更新日期：2001-06-01 00:00:00
abstract：:Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1385/ENDO:12:2:99
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negative patients with MEN1-associated tumors represent phenocopies. By comparing mutation-positive and mut...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-01932-x
更新日期：2019-08-01 00:00:00
