Abstract:
:The adipocyte-derived catabolic protein leptin alters cell-mediated immunity and cytokine crosstalk. This may provide new insights into the altered immune response, seen in obese individuals. Therefore, we determined the tissue distribution of immune cells in diet-induced obese (dio) and normal weight F344 rats challenged with MADB106 tumor cells or leptin. Immune cell distribution in blood (by FACS analysis) and tissues (NK cells in spleen and liver, immunohistologically) as well as pro-inflammatory cytokines (IL-6, TNF-α; by flow cytometry) were investigated in 28 normal weight and 28 dio rats (n = 4-6/group). Pro-inflammatory cytokines were increased 3-fold for IL-6 and 7-fold for TNF-α in obese animals. Higher numbers of blood monocytes and NK cells were found in obese as compared to normal weight animals. In dio rats challenged with leptin and MADB106 tumor cells, monocyte numbers were decreased as compared to the obese control animals. Immunohistochemistry revealed an altered NK cell distribution in a compartment-, treatment-, and bodyweight-specific manner. In conclusion, our data reveal a distinct distribution pattern of monocytes and NK cells in dio rats as compared to normal weight littermates and an additional modulatory effect of a leptin- and MADB106 tumor cell challenge.
journal_name
Endocrinejournal_title
Endocrineauthors
Behrendt P,Buchenauer T,Horn R,Brabant G,Jacobs R,Bode F,Stephan M,Nave Hdoi
10.1007/s12020-010-9358-9subject
Has Abstractpub_date
2010-08-01 00:00:00pages
104-12issue
1eissn
1355-008Xissn
1559-0100journal_volume
38pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the as...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0451-3
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To assess the predictive value of some clinical and biochemical parameters, and of the +49 A/G polymorphism of the CTLA-4 gene, for long-term remission following the withdrawal of antithyroid drugs before starting antithyroid drug therapy. STUDY DESIGN:Observational, prospective and longitudinal study. METH...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1785-z
更新日期:2019-02-01 00:00:00
abstract::The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:3:267
更新日期:2003-12-01 00:00:00
abstract::PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0440-6
更新日期:2015-05-01 00:00:00
abstract::Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0038-4
更新日期:2014-05-01 00:00:00
abstract::Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) are synthesized and released from adrenal cells. Therefore, the effects of TNF-alpha and IL-6 on cortisol release from bovine zona fasciculata (ZF) cells were investigated. IL-6 (10-1000 pg/mL) significantly increased basal and adrenocorticotropic hormon...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:3:369
更新日期:2000-12-01 00:00:00
abstract::Initiation and maintenance of labor in humans is associated with an increase in prostaglandin synthesis by intrauterine tissues. The objective of the present study was to characterize the distribution of membrane-bound PGES (mPGES) protein and mPGES mRNA in human placenta, fetal membranes, and decidua at term and to d...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:3:219
更新日期:2003-04-01 00:00:00
abstract::We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0044-5
更新日期:2007-06-01 00:00:00
abstract::Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma are limited. The objectives of this study are to investigate carotid intima media thickness (IMT) as an indicator of atherosclerosis in subjects with non-functioning adrenal incidentaloma (AI) and to evaluate the factors that could be ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9160-8
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1398-y
更新日期:2017-10-01 00:00:00
abstract::Genetic mutations of steroidogenic factor 1 (also known as Ad4BP or Nr5a1) have increasingly been reported in patients with 46,XY disorders of sex development (46,XY disorders of sex development). However, because the phenotype of 46,XY disorders of sex development with a steroidogenic factor 1 mutation is wide-rangin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1043-1
更新日期:2016-11-01 00:00:00
abstract::Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9122-6
更新日期:2009-02-01 00:00:00
abstract::To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration. This was a single-center, cross-sectional study with consecutive enrollment. In total, 149 patients diagnosed with ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0855-8
更新日期:2016-08-01 00:00:00
abstract::Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738705
更新日期:1996-10-01 00:00:00
abstract::Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9908-z
更新日期:2013-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Endocrine
pub_type: 已发布勘误
doi:10.1007/s12020-020-02514-y
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Angiogenesis has been studied in pituitary neuroendocrine tumours (PitNETs), but the role of the tumour microenvironment (TME) in regulating PitNET angiogenesis remains unknown. We aimed to characterise the role of TME components in determining the angiogenetic PitNET profile, focusing on immune cells and tumou...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02478-z
更新日期:2020-12-01 00:00:00
abstract::The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorph...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0218-x
更新日期:2015-02-01 00:00:00
abstract::Acromegaly is a debilitating disease usually caused by a growth-hormone secreting pituitary adenoma. Therapeutic goals include improvement of symptoms, reduction in tumor mass, biochemical normalization, and preservation of pituitary function. Treatment options include transsphenoidal surgery, radiation, and pharmacot...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:20:3:291
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyro...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01913-0
更新日期:2019-07-01 00:00:00
abstract::Core needle biopsy (CNB) has been recently described as an accurate second-line test in thyroid inconclusive cytology (FNA). Here we retrospectively investigated the potential improvement given by Galectin-3, Cytokeratin-19, and HBME-1 on the accuracy of CNB in thyroid nodules with prior indeterminate FNA report. The ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0678-7
更新日期:2016-04-01 00:00:00
abstract::In these studies, we show that endothelin (ET), leukemia inhibitory factor (LIF), phenylephrine (PE), and prostaglandin F2alpha (PGF2alpha), which are all hypertrophic for neonatal rat cardiac myocytes in culture, induce distinct morphological, physiological, and genetic changes after a 48-h treatment. Transmission el...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:9:1:45
更新日期:1998-08-01 00:00:00
abstract::Interleukin-6 (IL-6) and tumor necrosis factor (TNF) are secreted by rat adrenal zona glomerulosa cells. Serotonin increases the release of aldosterone, corti-costerone, and cortisol from the adrenal cortex. Therefore, the effects of serotonin on IL-6 and TNF release from rat adrenal zona glomerulosa cells were invest...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02739062
更新日期:1996-12-01 00:00:00
abstract::Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the eff...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-009-9157-3
更新日期:2009-06-01 00:00:00
abstract::Environmental toxicants are thought to play a role in several estrogen-dependent diseases including breast cancer and endometriosis. Toxicant-induced increased aromatase activity, an enzyme complex that catalyzes the final rate-limiting step in the conversion of androgens to estrogens, has been reported in assays usin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:27:1:045
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovar...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01911-2
更新日期:2019-11-01 00:00:00
abstract::Alendronate is a well-established treatment for osteoporosis and suppresses bone resorption by a direct effect on osteoclasts and their precursors. The effect of alendronate on osteoclasts is produced, at least in part, by the receptor activator of nuclear factor kappaB ligand (RANKL) and the osteoprotegerin (OPG) syn...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9306-8
更新日期:2010-04-01 00:00:00
abstract::Silent information regulator T1 (SIRT1) plays several key roles in the regulation of lipid and glucose homoeostasis. In this study, we investigated the potential role of SIRT1 in hyperuricemia and explored possible mechanisms. Significant hyperuricemia was detected in C57BL/6 mice treated with oxonate and yeast polysa...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0896-7
更新日期:2016-08-01 00:00:00
abstract::Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress m...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0360-5
更新日期:2015-04-01 00:00:00
abstract::SHARPIN is a novel protein thought to interact with SHANK family and is widely expressed in multiple tissues/cells, including osteoblasts and osteoclasts. Loss-of-function of Sharpin develops the chronic proliferative dermatitis mutation (CPDM) in mice as well as a severe inflammation in other organs. The actual funct...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9418-1
更新日期:2011-04-01 00:00:00