SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway.

abstract：PURPOSE:Efficacy of multi-disciplinary weight management (MDM) in youth has not been compared to their routine care. OBJECTIVES:To compare body mass index z-score (zBMI) and blood test (lab) changes (Δ) in youth before and after MDM and to correlate bio-impedance analysis (BIA) and lab measurements. METHODS:We compar...

journal_title：Endocrine

authors： Majumdar I,Espino B,Bianco K,Epstein J,Mamilly L,Harmon CM

更新日期：2019-08-01 00:00:00

abstract：:The possible association between low skeletal muscle mass and cardiovascular disease (CVD) risk factors necessitates estimation of muscle mass even in subjects with normal body mass index (BMI). This study was aimed to investigate optimal cutoffs for skeletal muscle mass reflecting CVD risk factors and to evaluate the...

journal_title：Endocrine

authors： Kim Y,Han BD,Han K,Shin KE,Lee H,Kim TR,Cho KH,Kim DH,Kim YH,Kim H,Nam GE

更新日期：2015-11-01 00:00:00

abstract：:Recently, an endogenous ligand has been described for the growth hormone secretagogue receptor (GHS-R), named ghrelin. It was originally isolated from the stomach, but it is also present in the hypothalamus, where the highest concentration of GHS-R has been detected. It is well established that synthetic GHSs exert th...

journal_title：Endocrine

authors： Korbonits M,Kojima M,Kangawa K,Grossman AB

更新日期：2001-02-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, the anterior pituitary, and the endocrine pancreas. Our patient was a 58-year-old man who manifested typical features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and lipom...

journal_title：Endocrine

authors： Nishiuchi T,Imachi H,Murao K,Fujiwara M,Muraoka T,Kikuchi F,Nishiuchi Y,Kushida Y,Haba R,Ishida T

更新日期：2009-08-01 00:00:00

abstract：:Melatonin, a pineal hormone, is known to be an important neurohormonal factor involved in the timing of reproductive events which occur seasonally in various mammalian species. In order to evaluate the influence of melatonin on neurons which are producing gonadotropin-releasing hormone (GnRH), we studied the effect of...

journal_title：Endocrine

authors： Li S,Pelletier G

更新日期：1995-07-01 00:00:00

abstract：:Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress m...

journal_title：Endocrine

authors： Kawamoto R,Kohara K,Katoh T,Kusunoki T,Ohtsuka N,Abe M,Kumagi T,Miki T

更新日期：2015-04-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnos...

journal_title：Endocrine

authors： Mayo JC,Sainz RM,Tan DX,Antolín I,Rodríguez C,Reiter RJ

更新日期：2005-07-01 00:00:00

abstract：:Metabolic syndrome has become a major public health problem worldwide and represents a common clinical condition in countries with a high incidence of obesity and western dietary patterns. Metabolic syndrome associates with common cancers at many sites, including liver, colorectal, and bladder cancers in men, and endo...

journal_title：Endocrine

authors： Esposito K,Capuano A,Giugliano D

更新日期：2014-04-01 00:00:00

abstract：:Although ghrelin in cord blood has been associated to birth weight, its role in fetal and postnatal growth has not been elucidated. The aim of this study was to analyze total ghrelin, acyl ghrelin (AG), and des-acyl ghrelin (DAG) in cord blood of newborns with idiopathic birth weight alterations, and to evaluate prote...

journal_title：Endocrine

authors： González-Domínguez MI,Lazo-de-la-Vega-Monroy ML,Zaina S,Sabanero M,Daza-Benítez L,Malacara JM,Barbosa-Sabanero G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and ...

journal_title：Endocrine

authors： Das L,Rai A,Mavuduru R,Vaiphei K,Sharma A,Gupta V,Bhadada SK,Lodha S,Panda N,Bhansali A,Singh P,Dutta P

更新日期：2020-08-01 00:00:00

abstract：:In all mammalian species, the 20 amino acids of the genetic code are required for net protein accretion. The nutritional supply of amino acids for growth is defined as the net umbilical uptake of amino acids, representing the net transfer from maternal circulation, through the placenta and then to the fetus, of essent...

journal_title：Endocrine

authors： Regnault TR,de Vrijer B,Battaglia FC

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:We retrospectively evaluated all patients with pituitary tumours treated in our department from 1/1/1997 to 01/11/2014. PATIENTS AND METHODS:Two hundred and fifteen patients (124 females, 91 males, mean age 50.9 years) were treated because of pituitary tumours. All patients underwent basal hormonal analys...

journal_title：Endocrine

authors： Askitis D,Tsitlakidis D,Müller N,Waschke A,Wolf G,Müller UA,Kloos C

更新日期：2018-05-01 00:00:00

abstract：:Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775)...

journal_title：Endocrine

authors： Pawlak-Adamska E,Frydecka I,Bolanowski M,Tomkiewicz A,Jonkisz A,Karabon L,Partyka A,Nowak O,Szalinski M,Daroszewski J

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...

journal_title：Endocrine

authors： Wang S,Sun H,Chen HY,Zhao ZF,Yang Y,Zhao YJ,Cui B,Ning G

更新日期：2007-04-01 00:00:00

abstract：:Alendronate is a well-established treatment for osteoporosis and suppresses bone resorption by a direct effect on osteoclasts and their precursors. The effect of alendronate on osteoclasts is produced, at least in part, by the receptor activator of nuclear factor kappaB ligand (RANKL) and the osteoprotegerin (OPG) syn...

journal_title：Endocrine

authors： Enjuanes A,Ruiz-Gaspà S,Peris P,Ozalla D,Alvarez L,Combalia A,Martínez de Osaba MJ,Monegal A,Pares A,Guañabens N

更新日期：2010-04-01 00:00:00

abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...

journal_title：Endocrine

authors： Sandhoff TW,McLean MP

更新日期：1996-10-01 00:00:00

abstract：:Fibromyalgia (FM) is a disease entity consisting of a heterogeneous cluster of symptoms that has thus far eluded identification of a causative etiology. The disease onset appears to follow physiological and/or psychological stressors and involves a subset of symptoms that are consistent with varied disorders found in ...

journal_title：Endocrine

authors： Shuer ML

更新日期：2003-10-01 00:00:00

abstract：PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...

journal_title：Endocrine

authors： Liu R,Xia Y,Chen C,Ye T,Huang X,Ma L,Hu Y,Jiang Y

更新日期：2019-12-01 00:00:00

abstract：:Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...

journal_title：Endocrine

authors： Guaraldi F,Prencipe N,di Giacomo V,Scanarini M,Gasco V,Gardiman MP,Berton AM,Ghigo E,Grottoli S

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:11β-hydroxylase deficiency accounts for 5% of congenital adrenal hyperplasia cases. Diagnosis suspiction is classically based on the association between abnormal virilization, precocious puberty, and hypertension in 46XX or 46XY subjects. We investigated two families with siblings presenting with opposed clinic...

journal_title：Endocrine

authors： Valadares LP,Pfeilsticker ACV,de Brito Sousa SM,Cardoso SC,de Moraes OL,Gonçalves de Castro LC,de Oliveira RS,Lofrano-Porto A

更新日期：2018-11-01 00:00:00

abstract：:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...

journal_title：Endocrine

authors： Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya K

更新日期：2002-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is significantly affected by environmental regulators impacting on genetic predisposition. Lifestyle changes can significantly modulate the phenotype of this disease. Diet, exercise, smoking, stress, and other factors adversely affect reproductive outcomes in PCOS. These influences can...

journal_title：Endocrine

authors： Norman RJ,Homan G,Moran L,Noakes M

更新日期：2006-08-01 00:00:00

abstract：:FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and...

journal_title：Endocrine

authors： Resmini E,Santos A,Aulinas A,Webb SM,Vives-Gilabert Y,Cox O,Wand G,Lee RS

更新日期：2016-12-01 00:00:00

abstract：:Fifty children ages 4-10 yr with type 1 diabetes mellitus volunteered to participate in a study to evaluate and compare a new needle-free device developed for growth hormone delivery. Children answered descriptive questions related to nervousness and worry, hurt or pain, redness or bleeding, and stinging and wetness. ...

journal_title：Endocrine

authors： Silverstein JH,Murray FT,Malasanos T,Myers S,Johnson SB,Frye K,Grossman M

更新日期：2001-06-01 00:00:00

abstract：:The main objective of this article is to study the psychosocial profile of patients of Cushing disease (CD) in a developing country setting. Eighteen patients with CD underwent a cross-sectional assessment regarding their socio-demographic and clinical profile, life events, social support, coping, dysfunction, quality...

journal_title：Endocrine

authors： Mattoo SK,Bhansali AK,Gupta N,Grover S,Malhotra R

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Recently, it has been confirmed that circulating miRNAs play an important role in disease pathogenesis and can be biomarkers of many autoimmune diseases. However, the knowledge about circulating miRNAs in Graves' disease (GD) is very limited. In this study, we aimed to identify circulating miRNAs as potential b...

journal_title：Endocrine

authors： Yao Q,Wang X,He W,Song Z,Wang B,Zhang J,Qin Q

更新日期：2019-07-01 00:00:00

abstract：:Hyponatremia has been observed in elderly patients treated with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. The pathogenesis of this effect is not known, but enhanced release of vasopressin (VP) and its renal actions may be a possible mechanism. Excess secretion of VP in combination with large fluid ...

journal_title：Endocrine

authors： Marar IE,Amico JA

更新日期：1998-02-01 00:00:00

abstract：:We have linked two human chorionic gonadotropin (hCG) beta-subunit cDNAs in tandem such that the expressed fusion protein consists of two mature beta-subunits joined through the carboxy terminal peptide of the first beta-subunit. A single glycine residue is inserted between the two subunits in the fusion protein. Chin...

journal_title：Endocrine

authors： Lobel L,Pollak S,Wang S,Chaney M,Lustbader JW

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Patients with cortisol secreting adrenal adenomas present with Cushing's syndrome (CS), while 5-15% of subjects with adrenal incidentalomas have subclinical hypercortisolism (SH) as they have biochemical abnormalities suggesting autonomous cortisol secretion without associated clinical features of CS. GOALS...

journal_title：Endocrine

authors： Khawandanah D,ElAsmar N,Arafah BM

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...

journal_title：Endocrine

authors： Sun H,Jiang XF,Wang S,Chen HY,Sun J,Li PY,Ning G,Zhao YJ

更新日期：2007-06-01 00:00:00