Abstract:
:Polycystic ovary syndrome (PCOS) is significantly affected by environmental regulators impacting on genetic predisposition. Lifestyle changes can significantly modulate the phenotype of this disease. Diet, exercise, smoking, stress, and other factors adversely affect reproductive outcomes in PCOS. These influences can be modulated by structure change in an individual or group. Lifestyle choices should be discussed in this group of patients. The role of insulin sensitizers, including metformin, has still to be determined in this condition.
journal_name
Endocrinejournal_title
Endocrineauthors
Norman RJ,Homan G,Moran L,Noakes Mdoi
10.1385/ENDO:30:1:35subject
Has Abstractpub_date
2006-08-01 00:00:00pages
35-43issue
1eissn
1355-008Xissn
1559-0100pii
ENDO:30:1:35journal_volume
30pub_type
杂志文章,评审相关文献
ENDOCRINE文献大全abstract::A great number of prospective studies have investigated the relationship between leisure time physical activity (LTPA) and metabolic syndrome (MetS) risk. However, the results have been inconsistent. The aim of this study was to clarify the relationship between LTPA and MetS risk. Literature databases were searched in...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-013-0110-0
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovar...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01911-2
更新日期:2019-11-01 00:00:00
abstract::Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9842-5
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Histologic and pTNM classification of differentiated thyroid cancer (DTC) is mandatory to assess risk of relapse, risk of death, and radioactive iodine administration. The impact of an expert central review of external pathology reports has not yet been reported. METHODS:Monocentric retrospective study to eval...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02531-x
更新日期:2020-10-31 00:00:00
abstract::Diabetes with hypertension is characterized by increased cerebrovascular pathology and poorer outcomes following stroke. In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine. Normal and dia...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:2:091
更新日期:2004-11-01 00:00:00
abstract::Hypertensive heart disease, here defined by the presence of pathologic left ventricular hypertrophy in the absence of a cause other than arterial hypertension, is characterized by complex changes in myocardial structure including enhanced cardiomyocyte growth and non-cardiomyocyte alterations that induce the remodelin...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-012-9649-4
更新日期:2012-08-01 00:00:00
abstract::Quality of life (QoL) is an important aspect that reflects the way people feel and function. The assessment of QoL quality of life is an essential tool for estimating the efficacy of any therapy in different pathophysiological conditions. In normal, healthy women, the perception of QoL can be significantly modified du...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:24:3:231
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1483-2
更新日期:2018-07-01 00:00:00
abstract::Thickened pituitary stalks (TPSs) on magnetic resonance imaging (MRI) result from diverse pathologies; therefore, it is essential to make specific diagnoses for clinical decision-making. The diagnoses and indications for surgical biopsies in patients with central diabetes insipidus (CDI) and TPSs are thoroughly discus...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-014-0184-3
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND AIM:A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in overweight subjects is still a matter of concern. We studied free cortisol (urinary free cortiso...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02392-4
更新日期:2020-08-01 00:00:00
abstract::Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the str...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9416-3
更新日期:2011-02-01 00:00:00
abstract::We validated the effect of prolactin-releasing peptide (PrRP) on prolactin (PRL) secretion from rat anterior pituitary cells in in vitro culture. We found that culture conditions considerably influenced the response of the anterior pituitary cells to PrRP. Longer culture term (4 d) was required to obtain better respon...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:12:3:215
更新日期:2000-06-01 00:00:00
abstract::Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-013-9892-3
更新日期:2013-08-01 00:00:00
abstract::Thyroid hormone (TH) abnormalities are common in patients with diabetes mellitus (DM). These thyroid hormone abnormalities have been associated with inflammatory activity in several conditions but this link remains unclear in DM. We assessed the influence of subclinical inflammation in TH metabolism in euthyroid diabe...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0651-5
更新日期:2016-01-01 00:00:00
abstract::The possible association between low skeletal muscle mass and cardiovascular disease (CVD) risk factors necessitates estimation of muscle mass even in subjects with normal body mass index (BMI). This study was aimed to investigate optimal cutoffs for skeletal muscle mass reflecting CVD risk factors and to evaluate the...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0577-y
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02451-w
更新日期:2020-08-10 00:00:00
abstract::Fifty children ages 4-10 yr with type 1 diabetes mellitus volunteered to participate in a study to evaluate and compare a new needle-free device developed for growth hormone delivery. Children answered descriptive questions related to nervousness and worry, hurt or pain, redness or bleeding, and stinging and wetness. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:15:1:015
更新日期:2001-06-01 00:00:00
abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract::The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to the human thyroid-stimulating hormone (TSH) receptor (TSHR), a potent a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:1:025
更新日期:2004-06-01 00:00:00
abstract::The oncogenic activation of the rearranged during transfection (RET) proto-oncogene has a main role in the pathogenesis of medullary thyroid cancer (MTC). Several lines of evidence suggest that RET function could be influenced by cyclic AMP (cAMP)-dependent protein kinase A (PKA) activity. We evaluated the in vitro an...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0597-7
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compar...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1468-1
更新日期:2018-01-01 00:00:00
abstract::This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. The information available suggests that these amino acids exert a stimulatory action on hypophysial prolactin. Administration of a glutamate receptor ago...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:28:3:303
更新日期:2005-12-01 00:00:00
abstract::Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:3:229
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of mi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1551-2
更新日期:2018-05-01 00:00:00
abstract::The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738959
更新日期:1997-04-01 00:00:00
abstract::Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the eff...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-009-9157-3
更新日期:2009-06-01 00:00:00
abstract::Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administratio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1020-8
更新日期:2016-10-01 00:00:00
abstract::Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated in Parkinson's disease patients treated with dopamine agonists. Retrospective studies in prolactinoma patients tre...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1120-5
更新日期:2017-01-01 00:00:00
abstract::We performed this study to investigate the prevalences of insulin resistance and metabolic syndrome (MetS) in a Chinese population with normal weight. We also examined whether fat mass is associated with insulin resistance and MetS in normal-weight individuals. Data were drawn from a cross-sectional study in China. Su...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0079-8
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1265-x
更新日期:2017-04-01 00:00:00