(99m)Tc-HYNIC-TOC scintigraphy in evaluation of active Graves' ophthalmopathy (GO).

abstract：:RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...

journal_title：Endocrine

authors： Zhang X,Healy C,Nothnick WB

更新日期：2012-08-01 00:00:00

abstract：:Studies designed to evaluate the short-term effects of incretin-related drugs in subjects with cardiac disease are still preliminary. In patients with heart failure, two of five studies showed that glucagon-like peptide-1 (GLP-1) infusion was associated with an absolute increase in left ventricular ejection fraction (...

journal_title：Endocrine

authors： Mikhail N

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyro...

journal_title：Endocrine

authors： Adamska A,Krentowska A,Łebkowska A,Hryniewicka J,Leśniewska M,Adamski M,Kowalska I

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. MATERIAL AND METHODS:Serum anti-pituitary and anti-hypothalamus antibodies ...

journal_title：Endocrine

authors： Chiloiro S,Giampietro A,Angelini F,Arena V,Stigliano E,Tartaglione T,Mattogno PP,D'Alessandris QG,Lauretti L,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-01-23 00:00:00

abstract：:The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T...

journal_title：Endocrine

authors： Ozdemir S,Yücel R,Dariyerli N,Toplan S,Akyolcu MC,Yigit G,Hatemi H

更新日期：2006-10-01 00:00:00

abstract：:Oestradiol (E(2)) alters lymphocyte functionin vitro including T cell DNA synthesis and B cell immunoglobulin production in human tonsillar, splenic and peripheral blood cells. We have investigated whether one mechanism for this effect is that E(2) modifies the expression of IL-2, IL-6 and IFN-γ mRNA in human tonsilla...

journal_title：Endocrine

authors： Evagelatou M,Farrant J

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:to assess bone damage and metabolic abnormalities in patients with Addison's disease given replacement doses of glucocorticoids and mineralocorticoids. METHODS:A total of 87 patients and 81 age-matched and sex-matched healthy controls were studied. The following parameters were measured: urinary cortisol, seru...

journal_title：Endocrine

authors： Camozzi V,Betterle C,Frigo AC,Zaccariotto V,Zaninotto M,De Caneva E,Lucato P,Gomiero W,Garelli S,Sabbadin C,Salvà M,Costa MD,Boscaro M,Luisetto G

更新日期：2018-02-01 00:00:00

abstract：:The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...

journal_title：Endocrine

authors： Waldmann J,Langer P,Habbe N,Fendrich V,Ramaswamy A,Rothmund M,Bartsch DK,Slater EP

更新日期：2009-06-01 00:00:00

abstract：:Fibromyalgia (FM) is a disease entity consisting of a heterogeneous cluster of symptoms that has thus far eluded identification of a causative etiology. The disease onset appears to follow physiological and/or psychological stressors and involves a subset of symptoms that are consistent with varied disorders found in ...

journal_title：Endocrine

authors： Shuer ML

更新日期：2003-10-01 00:00:00

abstract：:Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...

journal_title：Endocrine

authors： Cetin C,Baş F,Uçar A,Poyrazoğlu S,Saka N,Bundak R,Darendeliler F

更新日期：2014-12-01 00:00:00

abstract：:Estrogens increase prolactin (PRL) synthesis and release in rats and humans, whereas pituitary-derived calcitonin-like immunoreactive peptide (pit-CT) inhibits PRL gene expression and release. To test the hypothesis that estrogens stimulate lactotrophs by diminishing pit-CT expression, the present studies examined eff...

journal_title：Endocrine

authors： Li Z,Shah GV

更新日期：1995-06-01 00:00:00

abstract：:Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they co...

journal_title：Endocrine

authors： Bruyère O,Reginster JY

更新日期：2015-02-01 00:00:00

abstract：:Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...

journal_title：Endocrine

authors： Yang H,Chang J,Chen W,Zhao L,Qu B,Tang C,Qi Y,Zhang J

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dopamine agonist (DA)-resistant prolactinomas are rare but they constitute a real challenge, since there are few therapeutic alternatives left for these patients. DESIGN AND SETTING:Proof-of-concept study at a tertiary care, referral center. PATIENTS AND METHODS:The studied population consis...

journal_title：Endocrine

authors： Sosa-Eroza E,Espinosa E,Ramírez-Rentería C,Mendoza V,Arreola R,Mercado M

更新日期：2018-08-01 00:00:00

abstract：:Thymic carcinoid is an important component of the tumor spectrum causing Ectopic ACTH Syndrome (EAS) and usually carries a poor prognosis. Efforts have been focused on exploring the mechanism of the excessive ACTH production in non-pituitary tumors, whereas few studies have reported the molecular events underlying the...

journal_title：Endocrine

authors： Liu RX,Wang WQ,Ye L,Bi YF,Fang H,Cui B,Zhou WW,Dai M,Zhang J,Li XY,Ning G

更新日期：2010-08-01 00:00:00

abstract：:Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-termina...

journal_title：Endocrine

authors： Gruber KA,Fan W,Akerberg H,Larhammar D,Chee MJ,Colmers WF,Cone RD

更新日期：2009-06-01 00:00:00

abstract：:Immediate postnatal overfeeding in rats, obtained by reducing the litter size, results in early-onset obesity. Such experimental paradigm programs overweight, insulin resistance, dyslipidemia, increased adipose glucocorticoid metabolism [up-regulation of glucocorticoid receptor (GR) and 11β-hydroxysteroid dehydrogenas...

journal_title：Endocrine

authors： Boullu-Ciocca S,Tassistro V,Dutour A,Grino M

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:The study aimed to disclose mortality pattern and quantitatively evaluate risks for cause-specific mortality among thyroid cancer survivors. METHODS:We included 173,710 patients from the Surveillance, Epidemiology, and End Results (SEER) database with thyroid cancer diagnosed between 1975 and 2015. Standardize...

journal_title：Endocrine

authors： Du B,Wang F,Wu L,Wang Z,Zhang D,Huang Z,Gao L,Li Y,Liang C,Li P,Yao R

更新日期：2020-08-08 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease, characterized by cutaneous and multi-organ fibrosis, and vascular abnormalities. Skin thickening is a characteristic feature of SSc and resembles myxedematous skin. Our aim was to correlate the degree of skin involvement in SSc patients with serum TSH levels, si...

journal_title：Endocrine

authors： Bagnato GL,Roberts WN,Fiorenza A,Arcuri C,Certo R,Trimarchi F,Ruggeri RM,Bagnato GF

更新日期：2016-02-01 00:00:00

abstract：:Estrogens regulate gene expression and cell proliferation in target tissues. In studies of estrogen-regulated gene expression, identification of appropriate housekeeping genes (HKGs), reference genes whose expression is not altered by treatment, is difficult. The goal of this study was to define HKGs unaltered by estr...

journal_title：Endocrine

authors： Schroder AL,Pelch KE,Nagel SC

更新日期：2009-04-01 00:00:00

abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...

journal_title：Endocrine

authors： Hunt N,Willey KP,Abend N,Balvers M,Jähner D,Northemann W,Ivell R

更新日期：1995-03-01 00:00:00

abstract：:Administration of RU486 to late pregnant rats results in preterm delivery 24 h after treatment and the induction of a luteolytic process after labor. We investigated whether functional changes occurring within the corpora lutea after RU486 treatment were associated with morphologic features of apoptotic cell death. Ra...

journal_title：Endocrine

authors： Telleria CM,Goyeneche AA,Cavicchia JC,Stati AO,Deis RP

更新日期：2001-07-01 00:00:00

abstract：:The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GP...

journal_title：Endocrine

authors： Kumar U

更新日期：2011-10-01 00:00:00

abstract：:In glucocorticoid-induced osteoporosis (GIO), both bone formation and resorption are altered, however, with a relative prevalence of resorption, consistent with the positive results that have been reported with bisphosphonate treatment. Many studies have investigated the effect of bisphosphonates (BPs), a widely used ...

journal_title：Endocrine

authors： Rossini M,Orsolini G,Viapiana O,Adami S,Gatti D

更新日期：2015-08-01 00:00:00

abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...

journal_title：Endocrine

authors： Sandhoff TW,McLean MP

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein sub...

journal_title：Endocrine

authors： Szalat A,Shpitzen S,Tsur A,Zalmon Koren I,Shilo S,Tripto-Shkolnik L,Durst R,Leitersdorf E,Meiner V

更新日期：2017-03-01 00:00:00

abstract：PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...

journal_title：Endocrine

authors： Liu R,Xia Y,Chen C,Ye T,Huang X,Ma L,Hu Y,Jiang Y

更新日期：2019-12-01 00:00:00

abstract：:In order to identify GH target cells in human tissues, we investigated the celiuiar distribution of human GH receptor (GHR) messenger RNA. This was performed byin situ hybridization and Northern blot hybridization using complementary radioactive DNA probe encoding part of the extracellular domain of the GHR. Several t...

journal_title：Endocrine

authors： Mertani HC,Delehaye-Zervas MC,Martini JF,Postel-Vinay MC,Morel G

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:In the general population, sleep disorders are associated with an increased risk of cognitive impairment. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have additional risk of cognitive impairment due to acromegaly treatmen...

journal_title：Endocrine

authors： Wennberg A,Lorusso R,Dassie F,Benavides-Varela S,Parolin M,De Carlo E,Fallo F,Mioni R,Vettor R,Semenza C,Maffei P

更新日期：2019-12-01 00:00:00

abstract：:We investigated the expression and activity of cytosolic phospholipase A2 (cPLA2) in the corpus luteum during spontaneous and induced luteolysis in pseudopregnant rats. In both models, luteal PLA2 activity rose in association with functional regression and persisted during the following structural regression. Tissue c...

journal_title：Endocrine

authors： Kurusu S,Sakaguchi S,Kawaminami M,Hashimoto I

更新日期：2001-04-01 00:00:00