Abstract:
:The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GPCR and RTK family constitute largest cell surface receptor proteins and regulate physiological functions of cells in response to external and internal stimuli. Notably, GPCRs and RTKs play major role in regulation of several key cellular functions which are associated with several pathological conditions including cancer biology, neurodegenerative and cardiovascular diseases. The focus of this review is to highlight the recent findings on the possible cross-talk between somatostatin receptors (members of GPCR family) and growth factor receptors like epidermal growth factor receptors (members of RTK family). Furthermore, functional consequences of such an interaction in modulation of signaling pathways linked to pathological conditions specifically in cancer are discussed.
journal_name
Endocrinejournal_title
Endocrineauthors
Kumar Udoi
10.1007/s12020-011-9524-8subject
Has Abstractpub_date
2011-10-01 00:00:00pages
168-80issue
2eissn
1355-008Xissn
1559-0100journal_volume
40pub_type
杂志文章,评审相关文献
ENDOCRINE文献大全abstract::The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1069-4
更新日期:2017-01-01 00:00:00
abstract::It is well established that hypothalamic dopamine (DA) is the major physiologic regulator of prolactin (PRL) secretion, exerting a tonic inhibition throughout most of the estrous cycle. A dramatic drop in the amount of DA perfusing the anterior pituitary occurs in the afternoon of proestrus and is critical for the pro...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:1-2:67
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To evaluate whether losartan is able to induce beige adipocytes formation, focusing on the thermogenic gene expression and adipocyte remodeling in the subcutaneous white adipose tissue of diet-induced obese mice. METHODS:Male C57BL/6 mice received a control diet (10% energy as lipids) or a high-fat diet (50% e...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1213-1
更新日期:2017-03-01 00:00:00
abstract::Initiation and maintenance of labor in humans is associated with an increase in prostaglandin synthesis by intrauterine tissues. The objective of the present study was to characterize the distribution of membrane-bound PGES (mPGES) protein and mPGES mRNA in human placenta, fetal membranes, and decidua at term and to d...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:3:219
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:To assess the effectiveness and safety of myoinositol for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primar...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-017-1442-y
更新日期:2018-01-01 00:00:00
abstract::Tumor suppressor p53 is a transcriptional factor that determines cell fate in response to multiple stressors, such as oxidative stress and endoplasmic reticulum stress, in the majority of cells. However, its role in pancreatic beta cells is not well documented. Our previous research has revealed that glycation-serum (...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0979-5
更新日期:2016-11-01 00:00:00
abstract::The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02994449
更新日期:1995-03-01 00:00:00
abstract::We performed a meta-analysis to analyze the associations of depression with pre-diabetes (PreDM), undiagnosed diabetes (UDM), and previously diagnosed diabetes (PDM), and whether the association was affected by important study characteristics. We searched relevant articles published in PubMed and EMBASE up to August, ...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-016-0869-x
更新日期:2016-07-01 00:00:00
abstract::Mammalian reproduction is dependent on both a successful pregnancy and on the subsequent period of lactation. In the rat, ovulation occurs shortly after parturition making it possible for a dam to be simultaneously pregnant and lactating. The present studies investigate the effect of placental hormones on suckling-ind...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738662
更新日期:1996-08-01 00:00:00
abstract::The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9733-9
更新日期:2013-04-01 00:00:00
abstract::Genetic mutations of steroidogenic factor 1 (also known as Ad4BP or Nr5a1) have increasingly been reported in patients with 46,XY disorders of sex development (46,XY disorders of sex development). However, because the phenotype of 46,XY disorders of sex development with a steroidogenic factor 1 mutation is wide-rangin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1043-1
更新日期:2016-11-01 00:00:00
abstract::Diabetes with hypertension is characterized by increased cerebrovascular pathology and poorer outcomes following stroke. In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine. Normal and dia...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:2:091
更新日期:2004-11-01 00:00:00
abstract::The influence of thyroid hormones on cardiovascular system is well established. Thyroid diseases can effectively enhance the alteration on cardiovascular system by influencing chronotropic and inotropic actions of the heart; altering the strength and the speed of contraction, the speed of relaxation, the duration of t...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-016-0923-8
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Patients with cortisol secreting adrenal adenomas present with Cushing's syndrome (CS), while 5-15% of subjects with adrenal incidentalomas have subclinical hypercortisolism (SH) as they have biochemical abnormalities suggesting autonomous cortisol secretion without associated clinical features of CS. GOALS...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1769-z
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Fatty acid binding protein 4 (FABP4) has been demonstrated to be secreted from adipocytes in an unconventional pathway associated with lipolysis. Circulating FABP4 is elevated in metabolic disorders and has been shown to affect various peripheral cells such as pancreatic β-cells, hepatocytes and macrophages, bu...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02157-8
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Negative-pressure wound therapy (NPWT) is an adjunct modality in diabetic foot ulcerations (DFUs). Randomized controlled trials (RCTs) have shown its advantage over standard approaches; however, data from observational studies remain scarce.We performed a systematic review of observational non-RCTs evaluating N...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02164-9
更新日期:2020-04-01 00:00:00
abstract::We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0044-5
更新日期:2007-06-01 00:00:00
abstract::The objectives of this study were to analyse the results of surgical treatment of multinodular goiter (MG) in a population with under 30 yr of age; (2) to determine the incidence and evolution of related thyroid carcinomas; and (3) to evaluate the rate of relapse. Eighty-one patients operated for MG and under 30 yr of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:27:3:245
更新日期:2005-08-01 00:00:00
abstract::Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0196-z
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02451-w
更新日期:2020-08-10 00:00:00
abstract::Molecular chaperones assist proteins to reach their mature and functional conformation. It has become apparent in recent years that chaperones function as part of a multiprotein heterocomplex that is potentially involved not only in protein folding, but also in intracellular trafficking and in targeting proteins for d...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:14:2:143
更新日期:2001-03-01 00:00:00
abstract::We have linked two human chorionic gonadotropin (hCG) beta-subunit cDNAs in tandem such that the expressed fusion protein consists of two mature beta-subunits joined through the carboxy terminal peptide of the first beta-subunit. A single glycine residue is inserted between the two subunits in the fusion protein. Chin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738625
更新日期:1999-06-01 00:00:00
abstract::Recently, an endogenous ligand has been described for the growth hormone secretagogue receptor (GHS-R), named ghrelin. It was originally isolated from the stomach, but it is also present in the hypothalamus, where the highest concentration of GHS-R has been detected. It is well established that synthetic GHSs exert th...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:14:1:101
更新日期:2001-02-01 00:00:00
abstract::Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:12:2:99
更新日期:2000-04-01 00:00:00
abstract::Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the as...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0451-3
更新日期:2015-05-01 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, the anterior pituitary, and the endocrine pancreas. Our patient was a 58-year-old man who manifested typical features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and lipom...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9183-1
更新日期:2009-08-01 00:00:00
abstract::Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9288-6
更新日期:2010-02-01 00:00:00
abstract::Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775)...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1096-1
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1307-4
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:The institutional database of the Thyroid Surgery Division in China-Japan Union Hospital of Jilin University was queried to audit time trend patterns in thyroid cancer (TC) management between 2008 and 2017. METHODS:Retrospective longitudinal analysis. Clinicopathological features and treatment strategies were ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02230-7
更新日期:2020-06-01 00:00:00