Abstract：
:Mammalian reproduction is dependent on both a successful pregnancy and on the subsequent period of lactation. In the rat, ovulation occurs shortly after parturition making it possible for a dam to be simultaneously pregnant and lactating. The present studies investigate the effect of placental hormones on suckling-induced prolactin (PRL) release and the contribution of placental hormones to milk synthesis and secretion. A rat choriocarcinoma cell line, Rcho-1, which secretes placental lactogens (PLs) following transplantation in vivo, attenuated suckling-induced PRL release on both d 9 and d 14 of lactation by 43 and 58%, respectively. When PRL secretion was completely inhibited by bromocriptine, a dopamine agonist, Rcho-1-bearing dams still maintained a normal litters weight gain, demonstrating that placental lactogens can continue an established lactation. The Rcho-1 tumors also initiated milk synthesis and secretion in nulliparous rats continuously exposed to pups. Whereas none of the 11 control virgins began lactating and had an average pup weight loss of 2.07 g, the Rcho-1-bearing rats began lactating, as evidenced by a significant reduction in pup weight loss. Thirty percent of these rats became fully lactationally competent. Northern blot analysis showed that the Rcho-1 tumors expressed both PL-I and PL-II mRNA in all experimental groups. These tumors also secreted PL-I into the circulation, as shown by radioimmunoassay.
journal_name
Endocrinejournal_title
Endocrineauthors
Flietstra RJ,Voogt JLdoi
10.1007/BF02738662subject
Has Abstractpub_date
1996-08-01 00:00:00pages
103-10issue
1eissn
1355-008Xissn
1559-0100journal_volume
5pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract：:Ames dwarf mice have primary deficiency of prolactin (PRL), growth hormone (GH), and thyroid-stimulating hormone (TSH), and live considerably longer than normal animals from the same line. In view of the documented effects of GH, PRL, and thyroid hormones on lean and fat body mass and skeletal growth, and the suspecte...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:20:1-2:149
更新日期：2003-02-01 00:00:00
abstract：:Growth hormone (GH) and prolactin share similarities in structure and function. We have previously shown that women with congenital isolated GH deficiency (IGHD) caused by a homozygous mutation in the GHRH receptor gene (GHRHR) (MUT/MUT) have a short reproductive life, with anticipated climacteric. At climacteric, the...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-013-9896-z
更新日期：2013-08-01 00:00:00
abstract：:We wanted to evaluate the cutaneous synthesis of 25OHD and cholecalciferol after one whole-body exposure to ultraviolet radiation type B (UVB) in a randomized setup. Healthy volunteers were randomized to one whole-body exposure in a commercial tanning bed with UVB emission (UVB/UVA ratio 1.8-2.0%) or an identical plac...
journal_title：Endocrine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12020-012-9641-z
更新日期：2012-10-01 00:00:00
abstract：:The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should...
journal_title：Endocrine
pub_type： 信件
doi：10.1007/s12020-011-9487-9
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate the effectiveness of ultrasound (US)-guided radiofrequency ablation (RFA) treatment of benign thyroid nodules in consecutive large number series. To find out whether there is any difference according to the nature of the nodules, nodules were subdivided into two groups of predominan...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1829-4
更新日期：2019-05-01 00:00:00
abstract：:Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1385/ENDO:13:2:193
更新日期：2000-10-01 00:00:00
abstract：:The role of membrane-associated tubulin in TRH receptor-G protein coupling was investigated with the use of compounds that influence tubulin function. TRH-stimulated G protein GTPase activity in GH(3) cell membranes was used to determine receptor-G protein coupling. TRH-stimulated GTPase activity was abolished by G(qα...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02738873
更新日期：1996-02-01 00:00:00
abstract：:Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775)...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-016-1096-1
更新日期：2017-01-01 00:00:00
abstract：:Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:30:1:121
更新日期：2006-08-01 00:00:00
abstract：:There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0489-2
更新日期：2015-06-01 00:00:00
abstract：:Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroid disease (AITD). The aim of the study was to investigate the association of AITD with 25(OH) vitamin D levels in women with polycystic ovary syndrome (PCOS). Fifty women with PCOS were consecutively en...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-015-0745-0
更新日期：2016-08-01 00:00:00
abstract：:Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the str...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-010-9416-3
更新日期：2011-02-01 00:00:00
abstract：:We have investigated the effects of different patterns of administration of recombinant human growth hormone (rhGH) on weight gain, organ growth, serum GH binding protein (GHBP) and insulin-like growth factor-l (IGF-1) levels in a series of studies using hypophysectomized (Hx) or GH-deficient dwarf (dw/dw) rats. Anima...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF03000203
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:In morbid obesity nonalcoholic fatty liver disease (NAFLD) is endemic. Aim of this study is to evaluate the diagnostic accuracy of the most common noninvasive methods for identify NAFLD and fibrosis in a cohort of morbid obese population. METHODS:Ninety morbid obese patients undergoing bariatric surgery (BS) a...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-02155-w
更新日期：2020-03-01 00:00:00
abstract：:Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-012-9842-5
更新日期：2013-08-01 00:00:00
abstract：:In arthropods, development is controlled by cholesterol-derived steroid hormones: the ecdysteroids. In vertebrates and insects, steroidogenesis is positively regulated and this is mediated by cAMP. In crustaceans, ecdysteroid biosynthesis by steroidogenic organs (Y-organs) is negatively regulated by a neuropeptide, th...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02738652
更新日期：1996-08-01 00:00:00
abstract：:Persistent organic pollutants (POPs) are endocrine-disrupting chemicals associated with metabolic syndrome and type 2 diabetes. In humans, little is known about their potential role on obesity. Adiponectin augments the effects of insulin on glucose homeostasis. The expression of adiponectin is reduced in obesity, insu...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0231-0
更新日期：2015-02-01 00:00:00
abstract：:Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02782760
更新日期：1996-04-01 00:00:00
abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02994449
更新日期：1995-03-01 00:00:00
abstract：:Immediate postnatal overfeeding in rats, obtained by reducing the litter size, results in early-onset obesity. Such experimental paradigm programs overweight, insulin resistance, dyslipidemia, increased adipose glucocorticoid metabolism [up-regulation of glucocorticoid receptor (GR) and 11β-hydroxysteroid dehydrogenas...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-015-0657-z
更新日期：2015-12-01 00:00:00
abstract：:The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to the human thyroid-stimulating hormone (TSH) receptor (TSHR), a potent a...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:24:1:025
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Low mineral mass and reduced bone strength with increased fracture risk are the main causes of morbidity in Thalassemia Major (TM). The pathogenesis is multifactorial and includes ineffective erythropoiesis with medullary expansion, multiple endocrine dysfunctions, direct iron bone deposition, deferoxamine-i...
journal_title：Endocrine
pub_type： 杂志文章,评审
doi：10.1007/s12020-019-02003-x
更新日期：2019-09-01 00:00:00
abstract：:Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-020-02471-6
更新日期：2020-12-01 00:00:00
abstract：UNLABELLED:Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. A...
journal_title：Endocrine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12020-012-9631-1
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:Hyponatremia is the most common electrolyte disorder in hospitalized patients, and its etiopathogenesis is related to an underlying tumor in 14% of cases. Hyponatremia has been associated with a worse outcome in several pathologies, including cancer, in which the leading cause of this electrolyte alteration is ...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-019-02135-0
更新日期：2020-02-01 00:00:00
abstract：:The aim is to study the association of estrogen receptor α (ERα) and estrogen receptor β (ERβ) gene polymorphisms and diplotypes with ovarian response to follicle-stimulating hormone (FSH) stimulation and the hormone levels [FSH, luteinizing hormone (LH), E2] at the third day of the menstrual cycle. Three hundred wome...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-014-0249-3
更新日期：2014-12-01 00:00:00
abstract：:There are few cases published in literature in which the use of intravenous dextrose as treatment for an insulinoma resulted in a metabolic acidosis. This is due perhaps to the usual method of administration, which is usually at low concentrations, for limited periods or low volumes. We present the case of a woman wit...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-010-9400-y
更新日期：2010-12-01 00:00:00
abstract：:Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1385/ENDO:28:2:171
更新日期：2005-11-01 00:00:00
abstract：:In order to analyse whether the participation of the dopaminergic system of the preoptic-anterior hypothalamic area (POA-AHA) in the regulation of ovulation is asymmetric and varies during the estrous cycle of the rat, as it occurs with the cholinergic system, the effects of a unilateral implant of haloperidol were st...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/BF02935642
更新日期：1995-06-01 00:00:00
abstract：PURPOSE:Acute porphyrias are metabolic disorders of heme biosynthesis characterized by acute life-threatening attacks. The diagnosis is often missed since clinical presentation is aspecific mimicking other medical and surgical conditions. Variegate porphyria (VP) is an autosomal dominant inherited disease with incomple...
journal_title：Endocrine
pub_type： 杂志文章
doi：10.1007/s12020-018-1569-5
更新日期：2018-09-01 00:00:00
