Abstract:
:The aim is to study the association of estrogen receptor α (ERα) and estrogen receptor β (ERβ) gene polymorphisms and diplotypes with ovarian response to follicle-stimulating hormone (FSH) stimulation and the hormone levels [FSH, luteinizing hormone (LH), E2] at the third day of the menstrual cycle. Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. ERα PvuII and XbaI polymorphisms as well as ERβ AluI polymorphism were genotyped. The FSH, LH, and E2 levels were determined at the third day of the menstrual cycle, while the follicular size, the follicle, and oocyte numbers were recorded during oocyte retrieval. PvuII CC, XbaI GG, and AluI GG women were characterized by increased amounts of large follicles compared to PvuII TT, XbaI AA, and AluI AA women (p = 0.045, 0.01, and 0.033, respectively). The PvuII CC/XbaI GG diplotype was also significantly associated with higher large follicle numbers compared to the PvuII TT/XbaI AA diplotype (p = 0.024). However, no associations were observed between ER gene polymorphisms and the hormonal profile, the follicle/oocyte numbers, and the pregnancy rates. ERα and ERβ genetic variants were associated with ovarian response to standard gonadotropin stimulation of women undergoing in-vitro fertilization affecting mainly the follicular growth.
journal_name
Endocrinejournal_title
Endocrineauthors
Lazaros L,Pamporaki C,Vlahos N,Takenaka A,Kitsou C,Kosmas I,Sofikitis N,Stefos T,Zikopoulos K,Hatzi E,Georgiou Idoi
10.1007/s12020-014-0249-3subject
Has Abstractpub_date
2014-12-01 00:00:00pages
930-5issue
3eissn
1355-008Xissn
1559-0100journal_volume
47pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract:PURPOSE:Analyze the role of somatostatin analogues (SSAs) in the treatment of sporadic and MEN1-related gastrinomas, trying to define whether recent trials have changed the landscape of gastrinoma therapy. METHODS:We evaluate the rationale of SSA use in the treatment of gastrinomas, summarize the current literature co...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-017-1420-4
更新日期:2018-04-01 00:00:00
abstract::In this study we analyzed whether corticosterone synthesis is involved in the regulation of adrenal gland type II deiodinase (AG-D2) activity during acute cold exposure. Two well-known inhibitors of steroidogenesis, aminoglutethimide (AGT) and metyrapone (MTP), were administered to male Wistar rats maintained either a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:15:1:087
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Low mineral mass and reduced bone strength with increased fracture risk are the main causes of morbidity in Thalassemia Major (TM). The pathogenesis is multifactorial and includes ineffective erythropoiesis with medullary expansion, multiple endocrine dysfunctions, direct iron bone deposition, deferoxamine-i...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-019-02003-x
更新日期:2019-09-01 00:00:00
abstract::The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9733-9
更新日期:2013-04-01 00:00:00
abstract::Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-016-1038-y
更新日期:2017-03-01 00:00:00
abstract::For analyzing the changes in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence of fever associated with the it. The study included 11 subj...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9664-5
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years. METHODS:A total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01928-7
更新日期:2019-07-01 00:00:00
abstract::External ATP is believed to initiate and propagate Ca(2+) signals co-ordinating the insulin release pulses within and among the different islets in the pancreas. The possibility that islet endothelial cells participate in this process was evaluated by comparing the effects on [Ca(2+)](i) of purinoceptor activation in ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-9004-3
更新日期:2007-08-01 00:00:00
abstract::In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:1:21
更新日期:2002-06-01 00:00:00
abstract:UNLABELLED:Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. OBJECTIVE:To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. SUBJECTS:Seventeen healthy overweight and obese subjects...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9090-x
更新日期:2008-06-01 00:00:00
abstract::Circadian rhythmicity is affected in obese subjects. This article analyzes the effect of a high-fat diet (35% fat) on 24-h changes circulating prolactin, luteinizing hormone (LH), testosterone, corticosterone, thyroid-stimulating hormone (TSH) and glucose, and pineal melatonin content, in rats. When body weight of rat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9066-x
更新日期:2008-04-01 00:00:00
abstract::Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism. As an animal model, 18 Zucker-rats were divided into three groups as follows: no medication (Control), metformin (600 mg/kg) with meal (Met), and...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-015-0786-4
更新日期:2016-05-01 00:00:00
abstract::Diabetes mellitus is a major risk factor for cardiovascular disease. However, the excess risk of death may vary substantially in subgroups of patients with type 2 diabetes, being highest in those younger than 55 years of age. A HbA1c value of 7.0 % or less is recommended for most patients with type 2 diabetes to reduc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0981-y
更新日期:2016-10-01 00:00:00
abstract::The secreted hepatokine fetuin-A emerges as an independent predictor of type 2 diabetes in adulthood. The overall aims of this study were: (1) to investigate the associations of fetuin-A with adiposity and insulin resistance, as well as its relationship with adipokines, in prepubertal children, and, (2) to evaluate wh...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1009-3
更新日期:2017-05-01 00:00:00
abstract::Mineralocorticoid and glucocorticoid hormones activate the expression of the Na/K ATPase beta1 through direct binding of the mineralocorticoid receptor (MR) and glucocorticoid receptors (GR) to a mineralocorticoid- and glucocorticoid-responsive element in the beta1 promoter region, but activation of the beta1 promoter...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:3:287
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Thiazolidinediones (TZDs) improve peripheral insulin sensitivity, but the effect on arterial stiffness is less clear. The aim of the present study was to assess the differential effect of pioglitazone or rosiglitazone on arterial stiffness and plasma levels of adiponectin and leptin in patients with type 2 d...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-008-9058-x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Dopamine agonist (DA)-resistant prolactinomas are rare but they constitute a real challenge, since there are few therapeutic alternatives left for these patients. DESIGN AND SETTING:Proof-of-concept study at a tertiary care, referral center. PATIENTS AND METHODS:The studied population consis...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-018-1638-9
更新日期:2018-08-01 00:00:00
abstract::Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-termina...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9141-3
更新日期:2009-06-01 00:00:00
abstract::Increasing evidence suggests that inflammatory response may be a critical component of different brain pathologies. However, the role played by this reaction is not fully understood. The present findings suggest that neuroinflammtory mediators such as cytokines may be involved in a number of key steps in the pathologi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:29:2:243
更新日期:2006-04-01 00:00:00
abstract::Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:21:2:159
更新日期:2003-07-01 00:00:00
abstract::FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1083-6
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1297-2
更新日期:2017-06-01 00:00:00
abstract::To further understand the role of ovarian hormones in the function of the serotonin neural system, we investigated the effects of estradiol (E), progesterone (P), and raloxifene on 5HT 1A and 2C receptor protein expression in the dorsal raphe region using Western blot analysis. Adult rhesus macaques (Macaca mulatta) w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9087-5
更新日期:2008-06-01 00:00:00
abstract::The aim of the study was to assess the impact of sex hormone-binding globulin (SHBG) on bone mineral density (BMD) and bone turnover among Chinese middle-aged and elderly men. This cross-sectional study was carried out among 404 Chinese men aged over 45 years. BMD was measured with dual-energy X-ray absorptiometry, an...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-0155-0
更新日期:2014-11-01 00:00:00
abstract::Core needle biopsy (CNB) has been recently described as an accurate second-line test in thyroid inconclusive cytology (FNA). Here we retrospectively investigated the potential improvement given by Galectin-3, Cytokeratin-19, and HBME-1 on the accuracy of CNB in thyroid nodules with prior indeterminate FNA report. The ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0678-7
更新日期:2016-04-01 00:00:00
abstract::Interactions between testosterone, estradiol, and inhibin in the control of gonadotrophin secretion in males are poorly understood. Castrated rams were treated with steroid-free bovine follicular fluid (bFF), testosterone, or estradiol and for 7 d (2 x 2 x 2 factorial design). Given independently, none of the exogenou...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02778146
更新日期:1997-10-01 00:00:00
abstract:PURPOSE:Angiogenesis has been studied in pituitary neuroendocrine tumours (PitNETs), but the role of the tumour microenvironment (TME) in regulating PitNET angiogenesis remains unknown. We aimed to characterise the role of TME components in determining the angiogenetic PitNET profile, focusing on immune cells and tumou...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02478-z
更新日期:2020-12-01 00:00:00
abstract::Regular endurance exercise promotes metabolic and oxidative changes in skeletal muscle. Overexpression of interleukin-15 (IL-15) in mice exerts similar metabolic changes in muscle as seen with endurance exercise. Muscular IL-15 production has been shown to increase in mice after weeks of regular endurance running. Wit...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-013-9969-z
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negative patients with MEN1-associated tumors represent phenocopies. By comparing mutation-positive and mut...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01932-x
更新日期:2019-08-01 00:00:00
abstract::Despite the availability of many new treatment options for type 2 diabetes, the proportion of patients achieving the HbA1c target < 7.0% remains around 50%. We put forward the hypothesis that the unchanged HbA1c results, observed in the last decade in type 2 diabetes patients, are also a consequence of medication nona...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-017-1517-9
更新日期:2018-07-01 00:00:00