当前位置： SCI文献检索 > ENDOCRINE期刊下所有文献 > The N-terminal domain of the mineralocorticoid receptor modulates both mineralocorticoid receptor- and glucocorticoid receptor-mediated transactivation from Na/K ATPase beta1 target gene promoter.

The N-terminal domain of the mineralocorticoid receptor modulates both mineralocorticoid receptor- and glucocorticoid receptor-mediated transactivation from Na/K ATPase beta1 target gene promoter.

Abstract：

:Mineralocorticoid and glucocorticoid hormones activate the expression of the Na/K ATPase beta1 through direct binding of the mineralocorticoid receptor (MR) and glucocorticoid receptors (GR) to a mineralocorticoid- and glucocorticoid-responsive element in the beta1 promoter region, but activation of the beta1 promoter is inhibited by coexpression of both receptors. Here, using a series of mutated and chimeric receptors, we show that the N-terminal region of MR mediates an inhibitory effect on MR and GR activation from the beta1 promoter, in CV-1 cells. Deletion of the N-terminal region of MR (1-603) enhanced MR activation four-fold. Activation by chimeric MR, in which the N-terminus of GR replaces the N-terminal region of MR, was threefold that of wild-type MR. In addition, whereas coexpression of wild-type MR and GR was inhibitory, coexpression of chimeric MR and wild-type GR was nearly equal to that of MR. By contrast, mutated GR lacking its N-terminal region (1-420) was less efficient than the wild type in activating this promoter. These results demonstrate that the N-terminal domains of MR and GR have opposite transactivation properties and that MR region 1-603 is indeed inhibitory for both MR- and GR-mediated regulation of the Na/K ATPase beta1 gene promoter.

journal_name

Endocrine

journal_title

Endocrine

authors

Derfoul A,Robertson NM,Hall DJ,Litwack G

doi

10.1385/ENDO:13:3:287

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

287-95

issue

3

eissn

1355-008X

issn

1559-0100

pii

ENDO:13:3:287

journal_volume

13

pub_type

杂志文章

相关文献

ENDOCRINE文献大全
  • Mitogen-activated protein kinase activates human placental lactogen-B enhancer by an NF-IL6-dependent pathway.

    abstract：:Computer analysis of the human placental lactogen-B (hPL-B) enhancer reveals two putative binding sites for the transcription factor NF-IL6, but the role of NF-IL6 in the regulation of the enhancer is unknown. Using gel mobility shift and supershift assays, we demonstrated that NF-IL6 binds to both enhancer sites. Tra...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:12:1:47

    authors： Brar AK,Richards RG,Cheng YH,Richardson B,Kanda Y,Handwerger S

    更新日期：2000-02-01 00:00:00

  • Effects of aminoguanidine and vitamin C on collagen type IV in diabetic nephropathy rats.

    abstract：:The aim of this article is to investigate the effects of Aminoguanidine and vitamin C (VitC) on type IV collagen in diabetic nephropathy rats. Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were randomly divided into five groups: normal control group (n = 10), diabetes group (n = 10),...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-010-9419-0

    authors： Li Q,Ao X,Du Y,Li Y,Ou Y,Gong R,Sun X,Yang YX,Wen G

    更新日期：2011-06-01 00:00:00

  • Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis.

    abstract：:Subacute thyroiditis is a transient inflammatory thyroid disease of unknown etiology. The primary goal for treatment is to mitigate inflammation. The aim of this retrospective study was to compare the therapeutic effects of prednisolone and nonsteroidal anti-inflammation drugs in patients with subacute thyroiditis. In...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1122-3

    authors： Sato J,Uchida T,Komiya K,Goto H,Takeno K,Suzuki R,Honda A,Himuro M,Watada H

    更新日期：2017-01-01 00:00:00

  • The timing of parathyroid hormone measurement defines the cut-off values to accurately predict postoperative hypocalcemia: a prospective study.

    abstract：PURPOSE:Serum intact parathyroid hormone (iPTH) level is an early marker of post-thyroidectomy hypocalcemia. However, lack of methodological standardization to define timing and cut-off points of iPTH measurement limit its clinical applicability. Here, we evaluated the relationship between two distinct postoperative ti...

    journal_title：Endocrine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12020-018-1601-9

    authors： Filho EBY,Machry RV,Mesquita R,Scheffel RS,Maia AL

    更新日期：2018-08-01 00:00:00

  • Liquid L-thyroxine versus tablet L-thyroxine in patients on L- thyroxine replacement or suppressive therapy: a meta-analysis.

    abstract：PURPOSE:To compare the effectiveness of liquid L-T4 (L-thyroxine) and tablet L-T4 in patients on L-T4 replacement or suppressive therapy. METHODS:The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All prospective or randomized controlled studies (RCTs) compa...

    journal_title：Endocrine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s12020-018-1574-8

    authors： Laurent I,Tang S,Astère M,Wang KR,Deng S,Xiao L,Li QF

    更新日期：2018-07-01 00:00:00

  • 68Ga-DOTANOC and 18F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers.

    abstract：OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-019-01846-8

    authors： Souteiro P,Gouveia P,Ferreira G,Belo S,Costa C,Carvalho D,Duarte H,Sampaio IL

    更新日期：2019-05-01 00:00:00

  • Interleukin-6 production and deregulation of the hypothalamic-pituitary-adrenal axis in patients with major depressive disorders.

    abstract：:The present study was designed to determine whether an association exists between HPA activity and cytokine production in major depression (MD). In 9 patients with MD and 11 control subjects of both sexes, all drug-free, activity of the HPA axis was evaluated by circadian rhythm of plasma cortisol, 24-h free urinary c...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-006-0016-1

    authors： Humphreys D,Schlesinger L,Lopez M,Araya AV

    更新日期：2006-12-01 00:00:00

  • Functional expression of the dopamine-activated K(+) current in lactotrophs during the estrous cycle in female rats: correlation with prolactin secretory responses.

    abstract：:It is well established that hypothalamic dopamine (DA) is the major physiologic regulator of prolactin (PRL) secretion, exerting a tonic inhibition throughout most of the estrous cycle. A dramatic drop in the amount of DA perfusing the anterior pituitary occurs in the afternoon of proestrus and is critical for the pro...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:20:1-2:67

    authors： Gregerson KA

    更新日期：2003-02-01 00:00:00

  • A case of Riedel's thyroiditis with pleural and pericardial effusions.

    abstract：:Riedel's thyroiditis (RT) is a rare type of chronic thyroiditis of unproven etiology and definite treatment. It can be associated with retroperitoneal, mediastinal, orbital, and hepatic fibrosis. Symptoms arise mainly due to compression of neighboring structures. Surgery is usually required for a definite diagnosis an...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-009-9168-0

    authors： Erdoğan MF,Anil C,Türkçapar N,Ozkaramanli D,Sak SD,Erdoğan G

    更新日期：2009-06-01 00:00:00

  • Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice.

    abstract：:Ames dwarf mice have primary deficiency of prolactin (PRL), growth hormone (GH), and thyroid-stimulating hormone (TSH), and live considerably longer than normal animals from the same line. In view of the documented effects of GH, PRL, and thyroid hormones on lean and fat body mass and skeletal growth, and the suspecte...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:20:1-2:149

    authors： Heiman ML,Tinsley FC,Mattison JA,Hauck S,Bartke A

    更新日期：2003-02-01 00:00:00

  • Low investigation rate for adrenal incidentalomas.

    abstract：:The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should...

    journal_title：Endocrine

    pub_type： 信件

    doi：10.1007/s12020-011-9487-9

    authors： Bujawansa S,Bowen-Jones D

    更新日期：2011-08-01 00:00:00

  • Biochemical evidence of the functional recovery and regeneration of adrenal autotransplants in the rat spleen.

    abstract：:Adrenal transplantation may restore adrenal function after bilateral adrenalectomy or when adrenal function is lost. Thus, animal experiments could provide useful information before clinical application of adrenal transplantation. Using an experimental model of autotransplantion of a complete adrenal gland in the sple...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/endo:16:3:173

    authors： Allende G,Chavira R,Quintana-Stephan A

    更新日期：2001-12-01 00:00:00

  • Mitogen-activated protein kinase is involved in the progesterone-mediated induction of baboon glycodelin.

    abstract：:In the human and non-human primate the major secretory product of the uterine glandular epithelial cells is glycodelin. The expression of glycodelin is associated with elevated progesterone levels as its production peaks during the late luteal phase of the menstrual cycle and in early pregnancy. Consistent with our pr...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/endo:29:1:121

    authors： Jaffe RC,Ferguson-Gottschall SD,Fazleabas AT

    更新日期：2006-02-01 00:00:00

  • Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat.

    abstract：:Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comp...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1613-5

    authors： Lee KA,Lee NY,Park TS,Jin HY

    更新日期：2018-07-01 00:00:00

  • Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients.

    abstract：OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-007-0032-9

    authors： Wang S,Sun H,Chen HY,Zhao ZF,Yang Y,Zhao YJ,Cui B,Ning G

    更新日期：2007-04-01 00:00:00

  • Pituitary-adrenal axis and peripheral cortisol metabolism in obese patients.

    abstract：BACKGROUND AND AIM:A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in overweight subjects is still a matter of concern. We studied free cortisol (urinary free cortiso...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02392-4

    authors： Ceccato F,Lizzul L,Barbot M,Scaroni C

    更新日期：2020-08-01 00:00:00

  • Glucocorticoids curtail stimuli-induced CREB phosphorylation in TRH neurons through interaction of the glucocorticoid receptor with the catalytic subunit of protein kinase A.

    abstract：PURPOSE:Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS:Immunohistochem...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1223-z

    authors： Sotelo-Rivera I,Cote-Vélez A,Uribe RM,Charli JL,Joseph-Bravo P

    更新日期：2017-03-01 00:00:00

  • Recycling processes of cellular ascorbate generate oxidative stress in pancreatic tissues in in vitro system.

    abstract：:Ascorbate is a reducing agent, which is also known to oxidize cellular components. Our proposed mechanism of the oxidative action is as follows: Ascorbate is concentrated in the pancreas and is leaked in adverse conditions, and oxidized to dehydroascorbate. The dehydroascorbate is carried into cells by a glucose trans...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:18:1:91

    authors： Brown S,Georgatos M,Reifel C,Song JH,Shin SH,Hong M

    更新日期：2002-06-01 00:00:00

  • Prevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study.

    abstract：:The U.S. Institute of Medicine considers that a serum 25-hydroxyvitamin D (25OHD) concentration >20 ng/mL corresponds to optimal vitamin D status in the general population. Old studies of vitamin D status in the French general population have demonstrated high prevalence of insufficiency. We measured serum 25OHD, 1,25...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-0960-3

    authors： Souberbielle JC,Massart C,Brailly-Tabard S,Cavalier E,Chanson P

    更新日期：2016-08-01 00:00:00

  • Glucocorticoids activate the local renin-angiotensin system in bone: possible mechanism for glucocorticoid-induced osteoporosis.

    abstract：:Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0196-z

    authors： Yongtao Z,Kunzheng W,Jingjing Z,Hu S,Jianqiang K,Ruiyu L,Chunsheng W

    更新日期：2014-11-01 00:00:00

  • Effects of combined menaquinone-4 and PTH1-34 treatment on osetogenesis and angiogenesis in calvarial defect in osteopenic rats.

    abstract：PURPOSE:The aim of this study was to evaluate the effect of combining human parathyroid hormone (1-34) (PTH1-34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats. METHODS:Fourteen week olds were subject to craniotomy for the establishment of osteopenic animal models fed through a chroni...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1761-7

    authors： Weng SJ,Xie ZJ,Wu ZY,Yan DY,Tang JH,Shen ZJ,Li H,Bai BL,Boodhun V,Eric Dong XD,Yang L

    更新日期：2019-02-01 00:00:00

  • Presence of ghrelin in normal and adenomatous human pituitary.

    abstract：:Recently, an endogenous ligand has been described for the growth hormone secretagogue receptor (GHS-R), named ghrelin. It was originally isolated from the stomach, but it is also present in the hypothalamus, where the highest concentration of GHS-R has been detected. It is well established that synthetic GHSs exert th...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:14:1:101

    authors： Korbonits M,Kojima M,Kangawa K,Grossman AB

    更新日期：2001-02-01 00:00:00

  • Hyperthermal liquid, spray, and smog may be potential risk factors for recurrent laryngeal nerve thermal injury during thyroid surgeries.

    abstract：PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02451-w

    authors： Yu X,Liu C,Yan M,Gong W,Wang Y

    更新日期：2020-08-10 00:00:00

  • Selective effects of 8-Br-cAMP on agonists and antagonists of the glucocorticoid receptor.

    abstract：:RU486 has been reported to be a glucocorticoid receptor (GR) and a progesterone receptor (PR) antagonist. We have analysed RU486 activity on the GR in WCL-2 (CHO) cells and in COS-7 cells transiently transfected with the mouse GR and with the reporter MMTVCAT (MCAT). These cell lines do not contain any active progeste...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02917442

    authors： Zhang S,Danielsen M

    更新日期：1995-01-01 00:00:00

  • Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain.

    abstract：:Cholecystokinin (CCK) amide concentrations were reduced over 85% in all the major brain regions of carboxypeptidase E (Cpe)(fat)/Cpe(fat) mice in comparison to control mice. Using an radioimmunoassay (RIA) specific for glycine-extended CCK (CCK Gly), low levels of CCK Gly were detected in control (0.65 ng/g tissue) an...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:9:3:329

    authors： Wang W,Cain BM,Beinfeld MC

    更新日期：1998-12-01 00:00:00

  • Interrelationship between NO and androgenic activity in mice, Mus musculus, following temporal phase relation of serotonergic and dopaminergic neural oscillations.

    abstract：:The present study was designed to monitor the correlation of gonadal steroidogenic activity and nitric oxide (NO) of plasma and testis of male laboratory mouse, Mus musculus, under (1) control/basal and (2) experimental conditions. In the first study, male mice (n = 6) of three age groups (3-week-old sexually immature...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-013-0148-z

    authors： Singh VP,Chaturvedi CM

    更新日期：2014-08-01 00:00:00

  • Genetic regulation of the embryology of the pituitary gland and somatotrophs.

    abstract：:Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early diff...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1385/ENDO:12:2:99

    authors： Cohen LE

    更新日期：2000-04-01 00:00:00

  • Gonadotropin-releasing hormone receptor gene expression in rat anterior pituitary.

    abstract：:Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02782760

    authors： Mertani HC,Testart C,Ouhtit A,Brisson C,Morel G

    更新日期：1996-04-01 00:00:00

  • Suspected ontogeny of a recently described hypo-androgenic PCOS-like phenotype with advancing age.

    abstract：BACKGROUND:A recent report described a new PCOS-like phenotype in lean older infertile women, and was characterized by high age-specific anti-Müllerian hormone (AMH) but hypo- rather than the expected hyper-androgenism. The hypo-androgenism was, furthermore, characterized of, likely, adrenal origin and autoimmune etiol...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1498-8

    authors： Gleicher N,Kushnir VA,Darmon SK,Wang Q,Zhang L,Albertini DF,Barad DH

    更新日期：2018-03-01 00:00:00

  • Changes in oxidized low-density lipoprotein cholesterol are associated with changes in handgrip strength in Japanese community-dwelling persons.

    abstract：:Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress m...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0360-5

    authors： Kawamoto R,Kohara K,Katoh T,Kusunoki T,Ohtsuka N,Abe M,Kumagi T,Miki T

    更新日期：2015-04-01 00:00:00