Secretion of inhibin A and inhibin B during pregnancy and early postpartum period in Japanese monkeys.

Abstract:

:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, and betaB-subunits by immunohistochemistry. Serum concentrations of inhibin A showed a significant rise at the second quarter and maintained its level until term. Serum concentrations of inhibin B gradually increased until the fourth quarter. The concentration of both inhibins abruptly declined after delivery to the nonpregnant level. Positive staining of inhibin alpha-, betaA-, and betaB-subunits was observed in syncytiotrophoblast in the placenta by immunohistochemistry. These results demonstrated that large amounts of both dimeric inhibins are secreted from the placenta of Japanese monkeys.

journal_name

Endocrine

journal_title

Endocrine

authors

Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya K

doi

10.1385/ENDO:18:1:21

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

21-5

issue

1

eissn

1355-008X

issn

1559-0100

pii

ENDO:18:1:21

journal_volume

18

pub_type

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