Abstract:
:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, and betaB-subunits by immunohistochemistry. Serum concentrations of inhibin A showed a significant rise at the second quarter and maintained its level until term. Serum concentrations of inhibin B gradually increased until the fourth quarter. The concentration of both inhibins abruptly declined after delivery to the nonpregnant level. Positive staining of inhibin alpha-, betaA-, and betaB-subunits was observed in syncytiotrophoblast in the placenta by immunohistochemistry. These results demonstrated that large amounts of both dimeric inhibins are secreted from the placenta of Japanese monkeys.
journal_name
Endocrinejournal_title
Endocrineauthors
Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya Kdoi
10.1385/ENDO:18:1:21subject
Has Abstractpub_date
2002-06-01 00:00:00pages
21-5issue
1eissn
1355-008Xissn
1559-0100pii
ENDO:18:1:21journal_volume
18pub_type
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