Abstract:
:Retinol binding protein 4 (RBP4) is a novel adipocyte-secreted protein that contributes to systemic insulin resistance. Experiments in mice suggest that elevated RBP4 causes insulin resistance. In the present study, we determined serum RBP4 concentration and evaluated its association with insulin resistance in women with polycystic ovarian syndrome (PCOS); 39 PCOS women and 45 healthy control subjects were enrolled in this study. Serum RBP4, fasting plasma glucose (FPG) and fasting serum insulin (FINS) were measured in all subjects. Furthermore, oral glucose tolerance test (OGTT), Botnia clamp (an intravenous glucose tolerance test followed by an euglycemic hyperinsulinemic clamp), and measurements of sex hormones were performed in 13 control subjects and all the PCOS women. The levels of serum RBP4 were elevated in PCOS women compared with the control (11.69 +/- 6.72 versus 7.75 +/- 5.96 microg/mL, p = 0.006). RBP4 levels were positively correlated with WHR (r = 0.216, p = 0.048), and intravenous glucose tolerance test beta cell index (IVGTT-beta index) which reflected beta cell function (r = 0.309, p = 0.028), but were inversely correlated with M value during Botnia clamp, which represented insulin sensitivity (r = -0.362, p = 0.008). No correlation was found between RBP4 and age, BMI, blood pressure, FPG, FINS, 2-h postprandial glucose, 2-h postprandial insulin, free testosterone, total testosterone, follicle-stimulating hormone (FSH), or luteinizing hormone (LH). In a linear stepwise regression analysis with a model including age, BMI, WHR, free testosterone, IVGTT-beta index, and M value as independent variables, only M value showed significant correlation with serum RBP4 levels (r2 = 0.105, f = 6.640, p = 0.012). In conclusion, serum RBP4 levels are significantly increased in PCOS women and associated with insulin resistance, which indicates that RBP4 may be a contributing factor linking adipose tissue with insulin resistance in PCOS.
journal_name
Endocrinejournal_title
Endocrineauthors
Weiping L,Qingfeng C,Shikun M,Xiurong L,Hua Q,Xiaoshu B,Suhua Z,Qifu Ldoi
10.1007/s12020-006-0006-3subject
Has Abstractpub_date
2006-12-01 00:00:00pages
283-7issue
3eissn
1355-008Xissn
1559-0100pii
ENDO:30:3:283journal_volume
30pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::The anterior pituitary gland of the Siberian hamster contains high concentrations of tachykinins compared to other laboratory rodents. In this investigation we studied the relative quantities of neurokinin A (NKA), neuropeptide gamma (NPG), and neuropeptide K (NPK) present in extracts of anterior pituitaries from this...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02935690
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-007-0039-2
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:Serum intact parathyroid hormone (iPTH) level is an early marker of post-thyroidectomy hypocalcemia. However, lack of methodological standardization to define timing and cut-off points of iPTH measurement limit its clinical applicability. Here, we evaluated the relationship between two distinct postoperative ti...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-018-1601-9
更新日期:2018-08-01 00:00:00
abstract::Growth hormone (GH) and prolactin share similarities in structure and function. We have previously shown that women with congenital isolated GH deficiency (IGHD) caused by a homozygous mutation in the GHRH receptor gene (GHRHR) (MUT/MUT) have a short reproductive life, with anticipated climacteric. At climacteric, the...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9896-z
更新日期:2013-08-01 00:00:00
abstract::Remarkable decreases in growth hormone (GH) secretion accompany healthy aging. The pathophysiology of this hyposomatotropism is confounded by concurrent changes in body composition (with increased visceral fat), physiological declines in estrogen and androgen concentrations, differences in gender responses to aging, a...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/BF02778061
更新日期:1997-08-01 00:00:00
abstract::Total bilirubin, not direct or indirect bilirubin, has been reported to associate inversely with metabolic syndrome. Therefore, we aimed to evaluate the association between bilirubin subtypes and metabolic syndrome among the Korean population. This study included 5,231 Koreans (3,008 men, 2,223 women) aged 30-87 years...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9417-2
更新日期:2011-04-01 00:00:00
abstract::Thickened pituitary stalks (TPSs) on magnetic resonance imaging (MRI) result from diverse pathologies; therefore, it is essential to make specific diagnoses for clinical decision-making. The diagnoses and indications for surgical biopsies in patients with central diabetes insipidus (CDI) and TPSs are thoroughly discus...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-014-0184-3
更新日期:2014-09-01 00:00:00
abstract::There are few cases published in literature in which the use of intravenous dextrose as treatment for an insulinoma resulted in a metabolic acidosis. This is due perhaps to the usual method of administration, which is usually at low concentrations, for limited periods or low volumes. We present the case of a woman wit...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9400-y
更新日期:2010-12-01 00:00:00
abstract::In this study we analyzed whether corticosterone synthesis is involved in the regulation of adrenal gland type II deiodinase (AG-D2) activity during acute cold exposure. Two well-known inhibitors of steroidogenesis, aminoglutethimide (AGT) and metyrapone (MTP), were administered to male Wistar rats maintained either a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:15:1:087
更新日期:2001-06-01 00:00:00
abstract::Insulin resistance in skeletal muscle is a key feature in the pathogenesis of type 2 diabetes (T2D) that often manifests early in its development. Pharmaceutical and dietary strategies have targeted insulin resistance to control T2D, and many natural products with excellent pharmacological properties are good candidat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0599-5
更新日期:2015-11-01 00:00:00
abstract::Growth hormone-releasing hormone (GHRH) and somatostatin are the most important hypothalamic neurohormones controlling growth hormone (GH) secretion. Several neurotransmitters and neuropeptides also play an important role in the control of GH secretion, mainly acting via modulation of GHRH and somatostatin. In the pas...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/endo:14:1:035
更新日期:2001-02-01 00:00:00
abstract::Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9842-5
更新日期:2013-08-01 00:00:00
abstract::To assess how early can estrogens induce female mating behaviors, rat pups 8-29 days old (D8-D29, respectively) were injected twice daily with estradiol benzoate (E) or oil (O) followed by progesterone (P) or oil, and then observed for the estrogen-dependent ear wiggling (EW) and lordosis in response to natural stimul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9046-1
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:In previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02273-w
更新日期:2020-06-01 00:00:00
abstract::Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from indi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:29:1:27
更新日期:2006-02-01 00:00:00
abstract::The comparative efficacy and safety profiles of selected daily 1000 IU, weekly 7000 IU and monthly 30,000 IU vitamin D 3-not previously investigated-will be evaluated. Here, a prospective, randomized clinical trial, comparing efficacy and safety of a daily single dose of 1000 IU (group A) to a once-weekly 7000 IU dose...
journal_title:Endocrine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12020-016-1137-9
更新日期:2017-01-01 00:00:00
abstract::This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7-18 years in Bengbu, Anhui province was conducted. The investigation,...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9517-7
更新日期:2012-02-01 00:00:00
abstract::The goal of the present study was to investigate whether p53 antibodies (Abs) could be a relevant marker for papillary thyroid carcinoma (PTC). Three types of enzyme-linked immunosorbent assay (ELISA) methods were developed for the detection of p53 Abs, including p53-ELISA, phage-SS-ELISA, and phage-SP-ELISA. A total ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0243-9
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1297-2
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Fatty acid binding protein 4 (FABP4) has been demonstrated to be secreted from adipocytes in an unconventional pathway associated with lipolysis. Circulating FABP4 is elevated in metabolic disorders and has been shown to affect various peripheral cells such as pancreatic β-cells, hepatocytes and macrophages, bu...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02157-8
更新日期:2020-03-01 00:00:00
abstract::The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9178-y
更新日期:2009-06-01 00:00:00
abstract::Aging is associated with a significant decline in secretion of growth hormone. This in turn leads to reduced circulating IGF-I and changes in IGF-binding proteins. Growth hormone replacement to growth hormone-deficient individuals has been shown to improve quality of life, enhance bone and muscle mass, and reduce card...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:12:2:197
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:Efficacy of multi-disciplinary weight management (MDM) in youth has not been compared to their routine care. OBJECTIVES:To compare body mass index z-score (zBMI) and blood test (lab) changes (Δ) in youth before and after MDM and to correlate bio-impedance analysis (BIA) and lab measurements. METHODS:We compar...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01988-9
更新日期:2019-08-01 00:00:00
abstract::The Metastatic progression of solid tumors, such as thyroid cancer is a complex process which involves various factors. Current understanding on the role of epithelial-mesenchymal transition (EMT) in thyroid carcinomas suggests that EMT is implicated in the progression from follicular thyroid cancer (FTC) and papillar...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-019-02030-8
更新日期:2019-12-01 00:00:00
abstract::Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the as...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0451-3
更新日期:2015-05-01 00:00:00
abstract::Fibroadenomas are the most common benign breast tumors, occurring mainly in young women. Their responses to the hormonal environment are similar to those of normal breast tissue, which suggests that steroid receptors may play a role in tumor development. We evaluated the gene and protein expression of progesterone rec...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9176-0
更新日期:2009-06-01 00:00:00
abstract::The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:3:267
更新日期:2003-12-01 00:00:00
abstract::The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0348-1
更新日期:2015-03-01 00:00:00
abstract::Hypoxia is well known to decrease appetite and weight gain in growing rats, and to induce weight loss in humans. It has been hypothesized that this is mediated by a change in ghrelin, an orexigenic peptide synthesized and released primarily from the stomach. Rats were exposed to hypoxia for 7 d as neonates (birth-7 d ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:21:2:159
更新日期:2003-07-01 00:00:00
abstract::Thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane G protein-coupled receptor. The proliferative pathways induced by thyrotropin (TSH) in thyrocytes in vivo are not completely understood yet. The aim of this work is to evaluate if Ras can be induced by TSH in rat thyr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0029-4
更新日期:2007-04-01 00:00:00