Plasma concentrations of ir-inhibin, inhibin A, inhibin pro-alphaC, FSH, and estradiol-17beta during estrous cycle in mares and their relationship with follicular growth.

Abstract:

:The relationship among plasma levels of immunoreactive (ir)-inhibin, inhibin A, inhibin pro-alphaC, FSH, estradiol-17beta and follicular growth were investigated during the normal estrous cycle in mares. Seven mares were used for two successive normal estrous cycles. Follicular diameters and ovulation were obtained by transrectal ultrasonography, and blood samples were collected daily by jugular venipuncture for hormonal assay. The results showed that inhibin A was inversely correlated (r = -0.59, p < 0.0001) with FSH indicating its contribution to negative feedback control of FSH secretions from the pituitary gland. Estradiol-17beta increased during the follicular phase reaching a peak (37.9 +/- 3.8 pg/mL) 2 d before ovulation. Estradiol-17beta was positively correlated (r = 0.78, p < 0.0001) with inhibin A. The high levels of inhibin A and estradiol-17beta were associated with the growth of the preovulatory dominant follicle and inversely correlated with FSH suggesting that both hormones are products of the large dominant follicles and were responsible for the decline in FSH secretion during the follicular phase of estrous cycle. In conclusion, an inverse relationship between inhibin A and FSH was clearly demonstrated indicating that inhibin A has a key role in the negative feedback control of FSH from the pituitary gland. In addition, inhibin A and estra-diol-17beta secretions were associated with the growth of the preovulatory dominant follicle and were positively correlated.

journal_name

Endocrine

journal_title

Endocrine

authors

Medan MS,Nambo Y,Nagamine N,Shinbo H,Watanabe G,Groome N,Taya K

doi

10.1385/ENDO:25:1:07

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

7-14

issue

1

eissn

1355-008X

issn

1559-0100

pii

ENDO:25:1:07

journal_volume

25

pub_type

杂志文章
  • Effect of preproTRH antisense on thyrotropin-releasing hormone synthesis and viability of cultured rat diencephalic neurons.

    abstract::To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:15:1:079

    authors: Luo LG,Lee SL,Lechan RM,Jackson IM

    更新日期:2001-06-01 00:00:00

  • Verification of candidate microRNA markers for parathyroid carcinoma.

    abstract:PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of mi...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-018-1551-2

    authors: Hu Y,Zhang X,Cui M,Su Z,Wang M,Liao Q,Zhao Y

    更新日期:2018-05-01 00:00:00

  • The effect of aromatase inhibition on the sexual differentiation of the sheep brain.

    abstract::This study tested the hypothesis that aromatization of testosterone to estradiol is necessary for sexual differentiation of the sheep brain. Pregnant ewes (n = 10) were treated with the aromatase inhibitor 1,4,6- androstatriene-3,17-dione (ATD) during the period of gestation when the sheep brain is maximally sensitive...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:29:3:501

    authors: Roselli CE,Schrunk JM,Stadelman HL,Resko JA,Stormshak F

    更新日期:2006-06-01 00:00:00

  • Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes.

    abstract::In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-008-9048-z

    authors: Yang YS,Li XY,Hong J,Gu WQ,Zhang YF,Yang J,Song HD,Chen JL,Ning G

    更新日期:2007-12-01 00:00:00

  • Mitogen-activated protein kinase activates human placental lactogen-B enhancer by an NF-IL6-dependent pathway.

    abstract::Computer analysis of the human placental lactogen-B (hPL-B) enhancer reveals two putative binding sites for the transcription factor NF-IL6, but the role of NF-IL6 in the regulation of the enhancer is unknown. Using gel mobility shift and supershift assays, we demonstrated that NF-IL6 binds to both enhancer sites. Tra...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:12:1:47

    authors: Brar AK,Richards RG,Cheng YH,Richardson B,Kanda Y,Handwerger S

    更新日期:2000-02-01 00:00:00

  • Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta).

    abstract::RF amide peptide family with distinctive terminal -Arg-Phe-NH(2) signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebrates including influencing pituitary hormone secretion. More recently, two members of this fa...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-012-9672-5

    authors: Qaiser F,Wahab F,Wiqar MA,Hashim R,Leprince J,Vaudry H,Tena-Sempere M,Shahab M

    更新日期:2012-12-01 00:00:00

  • Prognostic importance of baseline neutrophil to lymphocyte ratio in patients with advanced papillary thyroid carcinomas.

    abstract::Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-013-0089-6

    authors: Kim JY,Park T,Jeong SH,Jeong CY,Ju YT,Lee YJ,Hong SC,Ha WS,Choi SK,Jung EJ

    更新日期:2014-08-01 00:00:00

  • Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-tetrahydrocortisone ratios in nonectopic Cushing's syndrome.

    abstract::We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:18:3:279

    authors: Stiefel P,García-Morillo JS,Jimenez L,Pamies E,Miranda ML,Carneado J,Villar J,Leal-Cerro A

    更新日期:2002-08-01 00:00:00

  • p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration.

    abstract::Thymic carcinoid is an important component of the tumor spectrum causing Ectopic ACTH Syndrome (EAS) and usually carries a poor prognosis. Efforts have been focused on exploring the mechanism of the excessive ACTH production in non-pituitary tumors, whereas few studies have reported the molecular events underlying the...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-010-9324-6

    authors: Liu RX,Wang WQ,Ye L,Bi YF,Fang H,Cui B,Zhou WW,Dai M,Zhang J,Li XY,Ning G

    更新日期:2010-08-01 00:00:00

  • Estrogen modulates expression of putative housekeeping genes in the mouse uterus.

    abstract::Estrogens regulate gene expression and cell proliferation in target tissues. In studies of estrogen-regulated gene expression, identification of appropriate housekeeping genes (HKGs), reference genes whose expression is not altered by treatment, is difficult. The goal of this study was to define HKGs unaltered by estr...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-009-9154-6

    authors: Schroder AL,Pelch KE,Nagel SC

    更新日期:2009-04-01 00:00:00

  • Evaluation of body composition changes, epicardial adipose tissue, and serum omentin-1 levels in overt hypothyroidism.

    abstract::Our aim was to investigate body composition changes, epicardial adipose tissue thickness (EATT), serum omentin-1 levels, and the relationship among them along with some atherosclerosis markers in overt hypothyroidism. Twenty-eight newly diagnosed overt hypothyroid patients were evaluated before and after 6 months of t...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-014-0460-2

    authors: Cerit ET,Akturk M,Altinova AE,Tavil Y,Ozkan C,Yayla C,Altay M,Demirtas C,Cakir N

    更新日期:2015-05-01 00:00:00

  • Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.

    abstract:OBJECTIVE:Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyro...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-019-01913-0

    authors: Adamska A,Krentowska A,Łebkowska A,Hryniewicka J,Leśniewska M,Adamski M,Kowalska I

    更新日期:2019-07-01 00:00:00

  • Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis

    abstract:INTRODUCTION:Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS:Members of...

    journal_title:Endocrine

    pub_type: 杂志文章,实务指引

    doi:10.1007/s12020-017-1290-9

    authors: Cianferotti L,Bertoldo F,Bischoff-Ferrari HA,Bruyere O,Cooper C,Cutolo M,Kanis JA,Kaufman JM,Reginster JY,Rizzoli R,Brandi ML

    更新日期:2017-05-01 00:00:00

  • Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors.

    abstract::The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/BF02738959

    authors: Martí O,Martín M,Gavaldà A,Giralt M,Hidalgo J,Hsu BR,Kuhn RW,Armario A

    更新日期:1997-04-01 00:00:00

  • Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line.

    abstract::Somatostatin exerts inhibitory effects on hormone secretion and cell proliferation via five receptor subtypes (SST1-SST5), whose internalization is regulated by β-arrestins. The receptor domains involved in these effects have been only partially elucidated. The aim of the study is to characterize the molecular mechani...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-016-1026-2

    authors: Cambiaghi V,Vitali E,Morone D,Peverelli E,Spada A,Mantovani G,Lania AG

    更新日期:2017-04-01 00:00:00

  • Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid.

    abstract:OBJECTIVE:Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). DESIGN AND METHODS:Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assesse...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:22:2:81

    authors: Buchs AE,Zehavi S,Sher O,Yeheskely E,Muggia-Sulam M,Sherman Y,Rapoport MJ

    更新日期:2003-11-01 00:00:00

  • Pituitary magnetic resonance imaging in Cushing's disease.

    abstract::Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...

    journal_title:Endocrine

    pub_type: 杂志文章,评审

    doi:10.1007/s12020-016-1038-y

    authors: Vitale G,Tortora F,Baldelli R,Cocchiara F,Paragliola RM,Sbardella E,Simeoli C,Caranci F,Pivonello R,Colao A,A.B.C. Group.

    更新日期:2017-03-01 00:00:00

  • Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus.

    abstract::Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were follo...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-016-1103-6

    authors: Liu C,Zhong C,Zhou X,Chen R,Wu J,Wang W,Li X,Ding H,Guo Y,Gao Q,Hu X,Xiong G,Yang X,Hao L,Xiao M,Yang N

    更新日期:2017-01-01 00:00:00

  • Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.

    abstract::To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study. Based on clinical, hormonal, and neuro-radiological data, relevant transcription factor genes were evaluated...

    journal_title:Endocrine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12020-014-0498-1

    authors: Baş F,Uyguner ZO,Darendeliler F,Aycan Z,Çetinkaya E,Berberoğlu M,Şiklar Z,Öcal G,Darcan Ş,Gökşen D,Topaloğlu AK,Yüksel B,Özbek MN,Ercan O,Evliyaoğlu O,Çetinkaya S,Şen Y,Atabek E,Toksoy G,Aydin BK,Bundak R

    更新日期:2015-06-01 00:00:00

  • Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas.

    abstract::The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-009-9178-y

    authors: Waldmann J,Langer P,Habbe N,Fendrich V,Ramaswamy A,Rothmund M,Bartsch DK,Slater EP

    更新日期:2009-06-01 00:00:00

  • Modulatory effects of neurohypophysary origin hormones on placental hormone secretion at term.

    abstract::Oxytocin (OT) and arginine-vasopressin (AVP) are two major neurohypophysary nonapeptides that have impor-tant roles during pregnancy and labor. Using the expiant model at term, we have examined the effect of physiologic concentrations of both nonapeptides on placental hormone secretion. We found that OT had a dose-dep...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/BF03021401

    authors: Barnea ER,Maruo T,Schurtz-Swirsky R

    更新日期:1995-04-01 00:00:00

  • Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus.

    abstract::Thyroid hormone (TH) abnormalities are common in patients with diabetes mellitus (DM). These thyroid hormone abnormalities have been associated with inflammatory activity in several conditions but this link remains unclear in DM. We assessed the influence of subclinical inflammation in TH metabolism in euthyroid diabe...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-015-0651-5

    authors: Moura Neto A,Parisi MC,Alegre SM,Pavin EJ,Tambascia MA,Zantut-Wittmann DE

    更新日期:2016-01-01 00:00:00

  • The association of obesity with hearing thresholds in women aged 18-40 years.

    abstract::An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanc...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-015-0755-y

    authors: Üçler R,Turan M,Garça F,Acar İ,Atmaca M,Çankaya H

    更新日期:2016-04-01 00:00:00

  • Calculation of therapeutic activity of radioiodine in Graves' disease by means of Marinelli's formula, using technetium (99mTc) scintigraphy.

    abstract::The therapeutic activity of 131I administered to patients with Graves' disease can be calculated by means of Marinelli's formula. The thyroidal iodine uptake (131IUmax) needed for the calculation is usually determined with the use of 131I. The purpose of the paper was to estimate 131IUmax on the basis of technetium up...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-016-1074-7

    authors: Szumowski P,Mojsak M,Abdelrazek S,Sykała M,Amelian-Fiłonowicz A,Jurgilewicz D,Myśliwiec J

    更新日期:2016-12-01 00:00:00

  • Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells.

    abstract:PURPOSE:The influence of the dipeptidyl peptidase-IV inhibitor, gemigliptin alone or in combination with metformin on survival, proliferation, and migration of thyroid carcinoma cells was investigated. METHODS:SW1736 and TPC-1 human thyroid carcinoma cells were used. RESULTS:Gemigliptin and metformin caused cell deat...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-017-1503-2

    authors: Kim SH,Kang JG,Kim CS,Ihm SH,Choi MG,Yoo HJ,Lee SJ

    更新日期:2018-02-01 00:00:00

  • Rat placental lactogens initiate and maintain lactation yet inhibit suckling-induced prolactin release.

    abstract::Mammalian reproduction is dependent on both a successful pregnancy and on the subsequent period of lactation. In the rat, ovulation occurs shortly after parturition making it possible for a dam to be simultaneously pregnant and lactating. The present studies investigate the effect of placental hormones on suckling-ind...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/BF02738662

    authors: Flietstra RJ,Voogt JL

    更新日期:1996-08-01 00:00:00

  • Evaluation of oxidative status in patients with hyperthyroidism.

    abstract::Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1007/s12020-011-9472-3

    authors: Aslan M,Cosar N,Celik H,Aksoy N,Dulger AC,Begenik H,Soyoral YU,Kucukoglu ME,Selek S

    更新日期:2011-10-01 00:00:00

  • Myristoylated alanine-rich C kinase substrate protein and mRNA in bovine corpus luteum during the estrous cycle.

    abstract::The bovine corpus luteum contains a myristoylated alanine-rich C kinase substrate (MARCKS) protein known to crosslink actin filaments in the cytoskeletal cortex associated with the plasma membrane. We conducted experiments to determine whether concentrations of MARCKS mRNA and protein in the bovine corpus luteum varie...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:12:3:289

    authors: Filley S,Supancic S,Salli U,Orwig K,Stormshak F

    更新日期:2000-06-01 00:00:00

  • Hypertriglyceridemic waist phenotype and abnormal glucose metabolism: a system review and meta-analysis.

    abstract:OBJECTIVE:This study was to perform a meta-analysis to assess the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal glucose metabolism. METHODS:The data sources were PubMed and EMBASE up to June 2018. Studies providing the relationship between HTW phenotype and abnormal glucose metabolism we...

    journal_title:Endocrine

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12020-019-01945-6

    authors: Ma CM,Liu XL,Lu N,Wang R,Lu Q,Yin FZ

    更新日期:2019-06-01 00:00:00

  • Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic rats.

    abstract::Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...

    journal_title:Endocrine

    pub_type: 杂志文章

    doi:10.1385/ENDO:30:1:121

    authors: Ding Y,Zou R,Judd RL,Zhong J

    更新日期:2006-08-01 00:00:00