Abstract:
:Our aim was to investigate body composition changes, epicardial adipose tissue thickness (EATT), serum omentin-1 levels, and the relationship among them along with some atherosclerosis markers in overt hypothyroidism. Twenty-eight newly diagnosed overt hypothyroid patients were evaluated before and after 6 months of thyroid hormone replacement therapy (THRT) and compared to the healthy subjects in this prospective longitudinal study. Body compositions were measured with dual-energy X-ray absorptiometry, and EATT was measured by echocardiography. Carotid intima-media thickness (c-IMT), flow-mediated dilatation (FMD), thyroid hormone levels, lipid parameters, high sensitive c-reactive protein, homocysteine, and omentin-1 levels were measured in all subjects. Body weight and lean body mass were higher in patients with hypothyroidism compared to euthyroid state after THRT (p = 0.012, 0.034, respectively). EATT was higher in patients with hypothyroidism than the control group (p < 0.001) and decreased with THRT (p = 0.012) but still remained higher than the control group (p < 0.001). Free T4 levels were found to be an independent factor to predict EATT (p < 0.001). In hypothyroid state, omentin-1 levels were lower than controls (p = 0.037) but increased in 6 months with THRT (p = 0.001). The c-IMT was higher, and FMD was lower in hypothyroidism compared to euthyroid state and control group (p < 0.05). Increasing lean body mass, but not adipose tissue mass, was found to be responsible for weight gain in hypothyroidism. The increased amount of EATT and decreased omentin-1 levels can contribute to the development of atherosclerosis in addition to other factors in hypothyroidism.
journal_name
Endocrinejournal_title
Endocrineauthors
Cerit ET,Akturk M,Altinova AE,Tavil Y,Ozkan C,Yayla C,Altay M,Demirtas C,Cakir Ndoi
10.1007/s12020-014-0460-2subject
Has Abstractpub_date
2015-05-01 00:00:00pages
196-203issue
1eissn
1355-008Xissn
1559-0100journal_volume
49pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract:CONTEXT:To prepare for radioactive iodine therapy in post total thyroidectomy patients with well-differentiated thyroid cancer (WDTC), either thyroid hormone withdrawal (THW) or administration of recombinant human thyrotropin (rhTSH) can be performed. OBJECTIVE:Our objective is to compare quality of life (QoL) paramet...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02238-z
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To compare long-term outcomes in patients with adrenal incidentalomas (AIs) with the response to a 1 mg overnight dexamethasone suppression test (DST). METHODS:Consecutive patients with "non-functional" AIs (n = 365) were examined. Patients with overt hormone excess, adrenocortical cancer and known malignancy ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1400-8
更新日期:2017-11-01 00:00:00
abstract::Quality of life (QoL) is an important aspect that reflects the way people feel and function. The assessment of QoL quality of life is an essential tool for estimating the efficacy of any therapy in different pathophysiological conditions. In normal, healthy women, the perception of QoL can be significantly modified du...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:24:3:231
更新日期:2004-08-01 00:00:00
abstract::Insulin resistance in skeletal muscle is a key feature in the pathogenesis of type 2 diabetes (T2D) that often manifests early in its development. Pharmaceutical and dietary strategies have targeted insulin resistance to control T2D, and many natural products with excellent pharmacological properties are good candidat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0599-5
更新日期:2015-11-01 00:00:00
abstract::Numerous reports of rapid steroid hormone effects in diverse cell types cannot be explained by the generally prevailing theory that centers on the activity of hormone receptors located exclusively in the nucleus. Cell membrane forms of steroid hormone receptors coupled to intracellular signaling pathways may also play...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:14:3:417
更新日期:2001-04-01 00:00:00
abstract::Fibroadenomas are the most common benign breast tumors, occurring mainly in young women. Their responses to the hormonal environment are similar to those of normal breast tissue, which suggests that steroid receptors may play a role in tumor development. We evaluated the gene and protein expression of progesterone rec...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9176-0
更新日期:2009-06-01 00:00:00
abstract::Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9809-6
更新日期:2013-06-01 00:00:00
abstract::Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the eff...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-009-9157-3
更新日期:2009-06-01 00:00:00
abstract::Alendronate is a well-established treatment for osteoporosis and suppresses bone resorption by a direct effect on osteoclasts and their precursors. The effect of alendronate on osteoclasts is produced, at least in part, by the receptor activator of nuclear factor kappaB ligand (RANKL) and the osteoprotegerin (OPG) syn...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9306-8
更新日期:2010-04-01 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, the anterior pituitary, and the endocrine pancreas. Our patient was a 58-year-old man who manifested typical features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and lipom...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9183-1
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Long-standing hypoglycemia can cause cognitive impairment, and whether recurrent severe hypoglycemia impacts cognitive function in patients with insulinoma has not been studied. This study focused on exploring the cognitive function in patients with insulinoma. METHODS:A prospective study was conducted to asse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01994-x
更新日期:2019-09-01 00:00:00
abstract::The bovine corpus luteum contains a myristoylated alanine-rich C kinase substrate (MARCKS) protein known to crosslink actin filaments in the cytoskeletal cortex associated with the plasma membrane. We conducted experiments to determine whether concentrations of MARCKS mRNA and protein in the bovine corpus luteum varie...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:12:3:289
更新日期:2000-06-01 00:00:00
abstract:UNLABELLED:Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. A...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-012-9631-1
更新日期:2012-08-01 00:00:00
abstract::The anterior pituitary gland of the Siberian hamster contains high concentrations of tachykinins compared to other laboratory rodents. In this investigation we studied the relative quantities of neurokinin A (NKA), neuropeptide gamma (NPG), and neuropeptide K (NPK) present in extracts of anterior pituitaries from this...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02935690
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:Serum intact parathyroid hormone (iPTH) level is an early marker of post-thyroidectomy hypocalcemia. However, lack of methodological standardization to define timing and cut-off points of iPTH measurement limit its clinical applicability. Here, we evaluated the relationship between two distinct postoperative ti...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-018-1601-9
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:This study was to perform a meta-analysis to assess the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal glucose metabolism. METHODS:The data sources were PubMed and EMBASE up to June 2018. Studies providing the relationship between HTW phenotype and abnormal glucose metabolism we...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-019-01945-6
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1265-x
更新日期:2017-04-01 00:00:00
abstract::Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9122-6
更新日期:2009-02-01 00:00:00
abstract::The secreted hepatokine fetuin-A emerges as an independent predictor of type 2 diabetes in adulthood. The overall aims of this study were: (1) to investigate the associations of fetuin-A with adiposity and insulin resistance, as well as its relationship with adipokines, in prepubertal children, and, (2) to evaluate wh...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1009-3
更新日期:2017-05-01 00:00:00
abstract::The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should...
journal_title:Endocrine
pub_type: 信件
doi:10.1007/s12020-011-9487-9
更新日期:2011-08-01 00:00:00
abstract::Plasma levels for insulin-like growth factor-I (IGF-I) steadily increase in female rats between 20 and 40 d of life, and this increase is intimately related to the wellknown growth spurt occurring at this age. Since specific actions of IGF-I related to sexual function have been described at the ovarian and hypothalami...
journal_title:Endocrine
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:Present study aims to explore the pathophysiological role of microRNA (miR)-29a in the process of obesity-related cardiomyopathy in human subjects and mice. METHODS:The expression level of circulating exosomal miR-29a was measured in 37 lean and 30 obese human subjects, and correlated with cardiac parameters. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1753-7
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyro...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01913-0
更新日期:2019-07-01 00:00:00
abstract::To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration. This was a single-center, cross-sectional study with consecutive enrollment. In total, 149 patients diagnosed with ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0855-8
更新日期:2016-08-01 00:00:00
abstract::A substantial number of pregnancies are complicated by gestational diabetes mellitus (GDM) and up to 70 % of women with GDM go on to develop type 2 diabetes. Given the extensive body of research suggesting physical activity reduces the risk of type 2 diabetes, facilitating physical activity, and reducing sedentary tim...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-015-0828-y
更新日期:2016-04-01 00:00:00
abstract::Hypertensive heart disease, here defined by the presence of pathologic left ventricular hypertrophy in the absence of a cause other than arterial hypertension, is characterized by complex changes in myocardial structure including enhanced cardiomyocyte growth and non-cardiomyocyte alterations that induce the remodelin...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-012-9649-4
更新日期:2012-08-01 00:00:00
abstract::Chronic stress can have a deleterious effect on the re-productive axis that, for females, is manifested in an increased incidence of infertility. However, gonadal steroids may, in turn, affect a female's response to stress as measured by activity within the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. What is no...
journal_title:Endocrine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1385/ENDO:26:2:089
更新日期:2005-03-01 00:00:00
abstract::Our aim was to evaluate the effectiveness of off-label use of sunitinib in patients with advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAI) therapy. We performed a retrospective analysis of patients treated in the setting of clinical practice in a University General Hospital. Eleven...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0356-1
更新日期:2015-03-01 00:00:00
abstract::Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9472-3
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02320-6
更新日期:2020-08-01 00:00:00