Abstract:
UNLABELLED:Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. Aim of our study is to meta-analyse published data about the diagnostic performance of SMSR PET or PET/CT in patients with thoracic and/or gastroenteropancreatic (GEP) NETs. A comprehensive computer literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through October 2011 and regarding SMSR PET or PET/CT in patients with NETs was carried out. Only studies in which SMSR PET or PET/CT were performed in patients with thoracic and/or GEP NETs were selected (medullary thyroid tumours and neural crest derived tumours were excluded from the analysis). Pooled sensitivity, pooled specificity and area under the ROC curve were calculated to measure the diagnostic accuracy of SMSR PET and PET/CT in NETs. RESULTS:Sixteen studies comprising 567 patients were included in this meta-analysis. The pooled sensitivity and specificity of SMSR PET or PET/CT in detecting NETs were 93% (95% confidence interval [95% CI]: 91-95%) and 91% (95% CI: 82-97%), respectively, on a per patient-based analysis. The area under the ROC curve was 0.96. In patients with suspicious thoracic and/or GEP NETs, SMSR PET and PET/CT demonstrated high sensitivity and specificity. These accurate techniques should be considered as first-line diagnostic imaging methods in patients with suspicious thoracic and/or GEP NETs.
journal_name
Endocrinejournal_title
Endocrineauthors
Treglia G,Castaldi P,Rindi G,Giordano A,Rufini Vdoi
10.1007/s12020-012-9631-1subject
Has Abstractpub_date
2012-08-01 00:00:00pages
80-7issue
1eissn
1355-008Xissn
1559-0100journal_volume
42pub_type
杂志文章,meta分析,评审相关文献
ENDOCRINE文献大全abstract::Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this st...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02471-6
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01995-w
更新日期:2019-09-01 00:00:00
abstract::Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9809-6
更新日期:2013-06-01 00:00:00
abstract::Cardiovascular morbidity and mortality are increased in patients with primary hyperparathyroidism (PHPT). We aimed to evaluate left ventricle systolic and diastolic functions with tissue Doppler imaging (TDI) and strain and strain rate echocardiography in patients with PHPT. Thirty-one patients with PHPT and 29 health...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0245-7
更新日期:2014-11-01 00:00:00
abstract::The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:3:267
更新日期:2003-12-01 00:00:00
abstract::Adrenal transplantation may restore adrenal function after bilateral adrenalectomy or when adrenal function is lost. Thus, animal experiments could provide useful information before clinical application of adrenal transplantation. Using an experimental model of autotransplantion of a complete adrenal gland in the sple...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:16:3:173
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-007-0039-2
更新日期:2007-06-01 00:00:00
abstract::Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-016-1038-y
更新日期:2017-03-01 00:00:00
abstract::Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0196-z
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To assess the effectiveness and safety of myoinositol for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primar...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-017-1442-y
更新日期:2018-01-01 00:00:00
abstract::There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0489-2
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controll...
journal_title:Endocrine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12020-017-1448-5
更新日期:2018-04-01 00:00:00
abstract::First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0619-5
更新日期:2016-03-01 00:00:00
abstract::To assess how early can estrogens induce female mating behaviors, rat pups 8-29 days old (D8-D29, respectively) were injected twice daily with estradiol benzoate (E) or oil (O) followed by progesterone (P) or oil, and then observed for the estrogen-dependent ear wiggling (EW) and lordosis in response to natural stimul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9046-1
更新日期:2007-12-01 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, the anterior pituitary, and the endocrine pancreas. Our patient was a 58-year-old man who manifested typical features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and lipom...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9183-1
更新日期:2009-08-01 00:00:00
abstract::To determine whether murine mammary growth is modulated by local insulin-like growth factor-1 (IGF-1) production, expression of recombinant IGF-1 was directed to the mammary glands of transgenic mice using an ovine prepro IGF-1 cDNA under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promote...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:3:251
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01846-8
更新日期:2019-05-01 00:00:00
abstract::The A1 adenosine receptor (A1AR) exerts important biological effects in the mammalian biology. To provide insights into the role A1AR action in human physiology, we characterized the pharmacologic properties of the human A1AR, examined somatic sites of A1AR gene expression, and identified the chromosomal location of t...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02746338
更新日期:1995-09-01 00:00:00
abstract::The relationship among plasma levels of immunoreactive (ir)-inhibin, inhibin A, inhibin pro-alphaC, FSH, estradiol-17beta and follicular growth were investigated during the normal estrous cycle in mares. Seven mares were used for two successive normal estrous cycles. Follicular diameters and ovulation were obtained by...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:1:07
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1786-y
更新日期:2019-02-01 00:00:00
abstract::The aim of this article is to investigate the effects of Aminoguanidine and vitamin C (VitC) on type IV collagen in diabetic nephropathy rats. Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were randomly divided into five groups: normal control group (n = 10), diabetes group (n = 10),...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-010-9419-0
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The study aimed to disclose mortality pattern and quantitatively evaluate risks for cause-specific mortality among thyroid cancer survivors. METHODS:We included 173,710 patients from the Surveillance, Epidemiology, and End Results (SEER) database with thyroid cancer diagnosed between 1975 and 2015. Standardize...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02445-8
更新日期:2020-08-08 00:00:00
abstract::To evaluate the role of central subfield thickness (CST), cube average thickness (CAT), and cube volume (CV) as imaging biomarkers for severity of diabetic retinopathy within the ETDRS-based grades of retinopathy using spectral domain optical coherence tomography (SD-OCT). This study aims to evaluate the role of macul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02093-7
更新日期:2019-12-01 00:00:00
abstract::FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1083-6
更新日期:2016-12-01 00:00:00
abstract::The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738959
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Diabetes self-management education is an essential part of diabetes care, but its impact on all-cause mortality risk of type 2 diabetes patients is unclear. A systematic review and meta-analysis aiming to elucidate the impact of diabetes self-management education on all-cause mortality risk of type 2 diabete...
journal_title:Endocrine
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12020-016-1168-2
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of mi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-018-1551-2
更新日期:2018-05-01 00:00:00
abstract::Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tom...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0280-4
更新日期:2014-11-01 00:00:00
abstract::RF amide peptide family with distinctive terminal -Arg-Phe-NH(2) signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebrates including influencing pituitary hormone secretion. More recently, two members of this fa...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9672-5
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:The aims of this study were to assess the role of an in-house competitive thyroglobulin assay (Tg-c) in the follow-up of metastatic differentiated thyroid carcinoma (DTC) patients who presented underestimated Tg measurements by immunometric assays (Tg-IMA) and to compare the results with IMA and LC-MS/MS Tg met...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02526-8
更新日期:2020-11-22 00:00:00