Reduced DNA methylation of FKBP5 in Cushing's syndrome.

abstract：:Stimulation of dopamine D2 receptors inhibits melanotrope pro-opiomelanocortin (POMC) biosynthesis and alpha-melanocyte-stimulating hormone (MSH) secretion. These effects are mediated by G-protein alpha i- and alpha o-subunits and are reversed by stimulating receptors linked to activation of G alpha s protein. Melanot...

journal_title：Endocrine

authors： Sands SA,Dickerson DS,Morris SJ,Chronwall BM

更新日期：1997-06-01 00:00:00

abstract：:Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from indi...

journal_title：Endocrine

authors： Frisard M,Ravussin E

更新日期：2006-02-01 00:00:00

abstract：:The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

journal_title：Endocrine

authors： Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

更新日期：2013-04-01 00:00:00

abstract：:The role of membrane-associated tubulin in TRH receptor-G protein coupling was investigated with the use of compounds that influence tubulin function. TRH-stimulated G protein GTPase activity in GH(3) cell membranes was used to determine receptor-G protein coupling. TRH-stimulated GTPase activity was abolished by G(qα...

journal_title：Endocrine

authors： Ravindra R,Forman LJ,Patel SA

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:Risk of cardiovascular disease (CVD) is increased in Graves' disease (GD). CVD is predicted by increased pulse wave velocity (PWV) and blood pressure (BP). GD and these risk factors are all associated with lower levels of vitamin D. We aimed to assess the effect of supplemental vitamin D on PWV and BP in GD. M...

journal_title：Endocrine

authors： Grove-Laugesen D,Malmstroem S,Ebbehoj E,Riis AL,Watt T,Hansen KW,Rejnmark L

更新日期：2019-11-01 00:00:00

abstract：:Silent information regulator T1 (SIRT1) plays several key roles in the regulation of lipid and glucose homoeostasis. In this study, we investigated the potential role of SIRT1 in hyperuricemia and explored possible mechanisms. Significant hyperuricemia was detected in C57BL/6 mice treated with oxonate and yeast polysa...

journal_title：Endocrine

authors： Wang J,Zhu XX,Liu L,Xue Y,Yang X,Zou HJ

更新日期：2016-08-01 00:00:00

abstract：:The optimal method for BRAF mutation detection remains to be determined despite advances in molecular detection techniques. The aim of this study was to compare, against classical Sanger sequencing, the diagnostic performance of two of the most recently developed, highly sensitive methods: BRAF V600E immunohistochemis...

journal_title：Endocrine

authors： Martinuzzi C,Pastorino L,Andreotti V,Garuti A,Minuto M,Fiocca R,Bianchi-Scarrà G,Ghiorzo P,Grillo F,Mastracci L

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and ...

journal_title：Endocrine

authors： Das L,Rai A,Mavuduru R,Vaiphei K,Sharma A,Gupta V,Bhadada SK,Lodha S,Panda N,Bhansali A,Singh P,Dutta P

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To perform an online survey about the use of Thyroid Imaging Reporting and Data System (TIRADS) classification in Italy. METHODS:An online questionnaire was administered to all members of the Italian Society of Medical and Interventional Radiology (Società Italiana di Radiologia Medica ed Interventistica, SIRM...

journal_title：Endocrine

authors： Mauri G,Gitto S,Cantisani V,Vallone G,Schiavone C,Papini E,Sconfienza LM

更新日期：2020-05-01 00:00:00

abstract：:Thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane G protein-coupled receptor. The proliferative pathways induced by thyrotropin (TSH) in thyrocytes in vivo are not completely understood yet. The aim of this work is to evaluate if Ras can be induced by TSH in rat thyr...

journal_title：Endocrine

authors： Leal AL,Pantaleão TU,Moreira DG,Marassi MP,Pereira VS,Rosenthal D,Corrêa da Costa VM

更新日期：2007-04-01 00:00:00

abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...

journal_title：Endocrine

authors： Sandhoff TW,McLean MP

更新日期：1996-10-01 00:00:00

abstract：:Subacute thyroiditis is a transient inflammatory thyroid disease of unknown etiology. The primary goal for treatment is to mitigate inflammation. The aim of this retrospective study was to compare the therapeutic effects of prednisolone and nonsteroidal anti-inflammation drugs in patients with subacute thyroiditis. In...

journal_title：Endocrine

authors： Sato J,Uchida T,Komiya K,Goto H,Takeno K,Suzuki R,Honda A,Himuro M,Watada H

更新日期：2017-01-01 00:00:00

abstract：:Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the as...

journal_title：Endocrine

authors： Li Y,Tian XX,Liu T,Wang RT

更新日期：2015-05-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...

journal_title：Endocrine

authors： Alkhateeb A,Marzouka NA,Tashtoush R

更新日期：2013-12-01 00:00:00

abstract：:Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the eff...

journal_title：Endocrine

authors： Ukinc K,Ersoz HO,Erem C,Hacihasanoglu AB,Karti SS

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:The aim of this study is to investigate in a population of adolescents living in Regione Campania, undergoing sun exposure at least 9 months per year the prevalence of severe deficiency (<20 ng/ml) or insufficiency (21-29 ng/ml) of 25-Hydroxyvitamin D (25(OH)D) levels and its relationship with individual body w...

journal_title：Endocrine

authors： Colao A,Muscogiuri G,Rubino M,Vuolo L,Pivonello C,Sabatino P,Pizzo M,Campanile G,Fittipaldi R,Lombardi G,Di Somma C

更新日期：2015-06-01 00:00:00

abstract：:RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...

journal_title：Endocrine

authors： Zhang X,Healy C,Nothnick WB

更新日期：2012-08-01 00:00:00

abstract：:Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...

journal_title：Endocrine

authors： Ding Y,Zou R,Judd RL,Zhong J

更新日期：2006-08-01 00:00:00

abstract：:To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...

journal_title：Endocrine

authors： Luo LG,Lee SL,Lechan RM,Jackson IM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Recently, it has been confirmed that circulating miRNAs play an important role in disease pathogenesis and can be biomarkers of many autoimmune diseases. However, the knowledge about circulating miRNAs in Graves' disease (GD) is very limited. In this study, we aimed to identify circulating miRNAs as potential b...

journal_title：Endocrine

authors： Yao Q,Wang X,He W,Song Z,Wang B,Zhang J,Qin Q

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). DESIGN AND METHODS:Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assesse...

journal_title：Endocrine

authors： Buchs AE,Zehavi S,Sher O,Yeheskely E,Muggia-Sulam M,Sherman Y,Rapoport MJ

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:The evaluation of skeletal fragility in Cushing's syndrome (CS) is a clinical challenge, since dual-energy X-ray absorptiometry (DXA) does not capture abnormalities in bone microstructure induced by glucocorticoid excess. Hypercortisolism was shown to increase bone marrow adiposity, but it is still unknown whet...

journal_title：Endocrine

authors： Ferraù F,Giovinazzo S,Messina E,Tessitore A,Vinci S,Mazziotti G,Lania A,Granata F,Cannavò S

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS:Members of...

journal_title：Endocrine

authors： Cianferotti L,Bertoldo F,Bischoff-Ferrari HA,Bruyere O,Cooper C,Cutolo M,Kanis JA,Kaufman JM,Reginster JY,Rizzoli R,Brandi ML

更新日期：2017-05-01 00:00:00

abstract：:The Metastatic progression of solid tumors, such as thyroid cancer is a complex process which involves various factors. Current understanding on the role of epithelial-mesenchymal transition (EMT) in thyroid carcinomas suggests that EMT is implicated in the progression from follicular thyroid cancer (FTC) and papillar...

journal_title：Endocrine

authors： Shakib H,Rajabi S,Dehghan MH,Mashayekhi FJ,Safari-Alighiarloo N,Hedayati M

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The primary aim of this study is to isolate cytokines specific for active Graves' orbitopathy (GO) in the tears of affected patients. The secondary aim is to identify other cytokines of interest and to look at the profile of their levels over time. METHODS:This is a prospective pilot study conducted at the Sin...

journal_title：Endocrine

authors： Yang M,Chung Y,Lang S,Yawata N,Seah LL,Looi A

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...

journal_title：Endocrine

authors： Xie T,Ding H,Xia M,Zhang X,Sun W,Liu T,Gu Y,Sun C,Hu F

更新日期：2018-12-01 00:00:00

abstract：:The aim is to study the association of estrogen receptor α (ERα) and estrogen receptor β (ERβ) gene polymorphisms and diplotypes with ovarian response to follicle-stimulating hormone (FSH) stimulation and the hormone levels [FSH, luteinizing hormone (LH), E2] at the third day of the menstrual cycle. Three hundred wome...

journal_title：Endocrine

authors： Lazaros L,Pamporaki C,Vlahos N,Takenaka A,Kitsou C,Kosmas I,Sofikitis N,Stefos T,Zikopoulos K,Hatzi E,Georgiou I

更新日期：2014-12-01 00:00:00

abstract：:Initiation and maintenance of labor in humans is associated with an increase in prostaglandin synthesis by intrauterine tissues. The objective of the present study was to characterize the distribution of membrane-bound PGES (mPGES) protein and mPGES mRNA in human placenta, fetal membranes, and decidua at term and to d...

journal_title：Endocrine

authors： Alfaidy N,Sun M,Challis JR,Gibb W

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:Long-standing hypoglycemia can cause cognitive impairment, and whether recurrent severe hypoglycemia impacts cognitive function in patients with insulinoma has not been studied. This study focused on exploring the cognitive function in patients with insulinoma. METHODS:A prospective study was conducted to asse...

journal_title：Endocrine

authors： Dai H,Chen H,Hong X,Han X,Xu Q,Pang H,Yuan J,Wang X,Xu P,Jiang J,Jiang R,Zhuang Z,Zhao Y,Wu W

更新日期：2019-09-01 00:00:00

abstract：:An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanc...

journal_title：Endocrine

authors： Üçler R,Turan M,Garça F,Acar İ,Atmaca M,Çankaya H

更新日期：2016-04-01 00:00:00