Reduced DNA methylation of FKBP5 in Cushing's syndrome.

abstract：:The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorph...

journal_title：Endocrine

authors： Gu SJ,Chen DH,Guo ZR,Zhou ZY,Hu XS,Wu M

更新日期：2015-02-01 00:00:00

abstract：:Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+ concentration ([Ca2+]i), which is determined by Ca2+ influx and release from intracellular Ca2+ storage sites. Ca2+ influx...

journal_title：Endocrine

authors： Han X,Zhu Y,Zhao Y,Chen C

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the effect of combining human parathyroid hormone (1-34) (PTH1-34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats. METHODS:Fourteen week olds were subject to craniotomy for the establishment of osteopenic animal models fed through a chroni...

journal_title：Endocrine

authors： Weng SJ,Xie ZJ,Wu ZY,Yan DY,Tang JH,Shen ZJ,Li H,Bai BL,Boodhun V,Eric Dong XD,Yang L

更新日期：2019-02-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour which frequently occurs in the context of the multiple endocrine neoplasia syndromes, where it coexists with other usually benign tumours. The clinical picture varies and distant metastases are frequently present at diagnosis. Calcitonin levels are elevated in the pre...

journal_title：Endocrine

authors： Alevizaki M,Kyratzoglou E,Bamias A,Tzanela M,Dimopoulos MA,Saltiki K

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved. METHODS:The patient group comprised 200 children with CHI that were treated at the Beijing Children's Hospital from January 2006 to December 2018. Th...

journal_title：Endocrine

authors： Xu ZD,Hui PP,Zhang W,Zeng Q,Zhang L,Liu M,Yan J,Wu YJ,Sang YM

更新日期：2021-01-27 00:00:00

abstract：:The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...

journal_title：Endocrine

authors： Shao Y,Ren H,Lv C,Ma X,Wu C,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...

journal_title：Endocrine

authors： Cetin C,Baş F,Uçar A,Poyrazoğlu S,Saka N,Bundak R,Darendeliler F

更新日期：2014-12-01 00:00:00

abstract：:Detection of connexin (Cx) proteins has been used as an indicator of the presence of structural and functional gap junctions in tissues. To examine the role of gap junctions during follicular growth and atresia, the presence of three major connexins, Cx43, Cx32, and Cx26, was evaluated in bovine ovaries by using immun...

journal_title：Endocrine

authors： Johnson ML,Redmer DA,Reynolds LP,Grazul-Bilska AT

更新日期：1999-02-01 00:00:00

abstract：:Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were follo...

journal_title：Endocrine

authors： Liu C,Zhong C,Zhou X,Chen R,Wu J,Wang W,Li X,Ding H,Guo Y,Gao Q,Hu X,Xiong G,Yang X,Hao L,Xiao M,Yang N

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Minimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carc...

journal_title：Endocrine

authors： Biamonte E,Solbiati L,Ierace T,Colombo P,Lavezzi E,Mazziotti G,Lania A

更新日期：2019-09-01 00:00:00

abstract：:Regulation of energy homeostasis is tightly controlled by the central nervous system (CNS). Several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, ...

journal_title：Endocrine

authors： Seoane-Collazo P,Fernø J,Gonzalez F,Diéguez C,Leis R,Nogueiras R,López M

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...

journal_title：Endocrine

authors： Souteiro P,Gouveia P,Ferreira G,Belo S,Costa C,Carvalho D,Duarte H,Sampaio IL

更新日期：2019-05-01 00:00:00

abstract：:Thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane G protein-coupled receptor. The proliferative pathways induced by thyrotropin (TSH) in thyrocytes in vivo are not completely understood yet. The aim of this work is to evaluate if Ras can be induced by TSH in rat thyr...

journal_title：Endocrine

authors： Leal AL,Pantaleão TU,Moreira DG,Marassi MP,Pereira VS,Rosenthal D,Corrêa da Costa VM

更新日期：2007-04-01 00:00:00

abstract：:Multiple lines of evidence have implicated the growth hormone (GH) axis in the regulation of erythropoiesis. To test the hypothesis that GH deficiency is associated with hematologic abnormalities, we analyzed pretreatment hemoglobin levels in 100 children with GH deficiency. Hemoglobin levels were decreased in childre...

journal_title：Endocrine

authors： Eugster EA,Fisch M,Walvoord EC,DiMeglio LA,Pescovitz OH

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. MATERIAL AND METHODS:Serum anti-pituitary and anti-hypothalamus antibodies ...

journal_title：Endocrine

authors： Chiloiro S,Giampietro A,Angelini F,Arena V,Stigliano E,Tartaglione T,Mattogno PP,D'Alessandris QG,Lauretti L,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-01-23 00:00:00

abstract：:Bone metabolism disorder has been identified to play a vital role in the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). The local renin-angiotensin system (RAS) in bone is newly defined to be closely related to the bone metabolism. However, it is unknown whether the local RAS is involved in GIOP. Adult ma...

journal_title：Endocrine

authors： Yongtao Z,Kunzheng W,Jingjing Z,Hu S,Jianqiang K,Ruiyu L,Chunsheng W

更新日期：2014-11-01 00:00:00

abstract：:Environmental factors have been implicated in the development of autoimmune thyroid disease (AITD). Anti-Saccaromyces Cerevisiae Antibodies (ASCA) were shown to be elevated in several autoimmune diseases. The aim of the study was to determine ASCA levels and their relationship with thyroid autoantibodies in patients w...

journal_title：Endocrine

authors： Yazıcı D,Aydın SZ,Yavuz D,Tarçın O,Deyneli O,Direskeneli H,Akalın S

更新日期：2010-10-01 00:00:00

abstract：:We have linked two human chorionic gonadotropin (hCG) beta-subunit cDNAs in tandem such that the expressed fusion protein consists of two mature beta-subunits joined through the carboxy terminal peptide of the first beta-subunit. A single glycine residue is inserted between the two subunits in the fusion protein. Chin...

journal_title：Endocrine

authors： Lobel L,Pollak S,Wang S,Chaney M,Lustbader JW

更新日期：1999-06-01 00:00:00

abstract：:Oxytocin (OT) and arginine-vasopressin (AVP) are two major neurohypophysary nonapeptides that have impor-tant roles during pregnancy and labor. Using the expiant model at term, we have examined the effect of physiologic concentrations of both nonapeptides on placental hormone secretion. We found that OT had a dose-dep...

journal_title：Endocrine

authors： Barnea ER,Maruo T,Schurtz-Swirsky R

更新日期：1995-04-01 00:00:00

abstract：:Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comp...

journal_title：Endocrine

authors： Lee KA,Lee NY,Park TS,Jin HY

更新日期：2018-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Endocrine

authors： Poli R,Scatolini M,Grosso E,Maletta F,Gallo M,Liscia D,Nelva A,Cesario F,Forte G,Metovic J,Volante M,Arvat E,Papotti M

更新日期：2020-12-01 00:00:00

abstract：:There are few cases published in literature in which the use of intravenous dextrose as treatment for an insulinoma resulted in a metabolic acidosis. This is due perhaps to the usual method of administration, which is usually at low concentrations, for limited periods or low volumes. We present the case of a woman wit...

journal_title：Endocrine

authors： Ramos-Prol A,del Olmo-García M,Pérez-Lázaro A,Caballero-Soto M,Argente-Pla M,León-de Zayas B,Merino-Torres JF

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. SUBJECT AND RESULTS:A patient with CDC73-associated metastatic parathyroid carcinoma was...

journal_title：Endocrine

authors： Sarquis M,Marx SJ,Beckers A,Bradwell AR,Simonds WF,Bicalho MAC,Daly AF,Betea D,Friedman E,De Marco L

更新日期：2020-01-01 00:00:00

abstract：:A substantial number of pregnancies are complicated by gestational diabetes mellitus (GDM) and up to 70 % of women with GDM go on to develop type 2 diabetes. Given the extensive body of research suggesting physical activity reduces the risk of type 2 diabetes, facilitating physical activity, and reducing sedentary tim...

journal_title：Endocrine

authors： Johnson ST,Lynch B,Vallance J,Davenport MH,Gardiner PA,Butalia S

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...

journal_title：Endocrine

authors： Song X,Wang J,Gao Y,Yu Y,Zhang J,Wang Q,Ma X,Estille J,Jin X,Chen Y,Mu Y

更新日期：2019-02-01 00:00:00

abstract：:Peptide hormones are generated by proteolytic processing of their respective protein precursors by several prohormone processing proteases. The peptide hormone PTHrP is widely expressed in normal and malignant tissues, where proPTHrP undergoes proteolytic processing to generate PTHrP peptides with distinct biological ...

journal_title：Endocrine

authors： Deftos LJ,Burton D,Hastings RH,Terkeltaub R,Hook VY

更新日期：2001-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is significantly affected by environmental regulators impacting on genetic predisposition. Lifestyle changes can significantly modulate the phenotype of this disease. Diet, exercise, smoking, stress, and other factors adversely affect reproductive outcomes in PCOS. These influences can...

journal_title：Endocrine

authors： Norman RJ,Homan G,Moran L,Noakes M

更新日期：2006-08-01 00:00:00

abstract：:Thyroid hormone (TH) abnormalities are common in patients with diabetes mellitus (DM). These thyroid hormone abnormalities have been associated with inflammatory activity in several conditions but this link remains unclear in DM. We assessed the influence of subclinical inflammation in TH metabolism in euthyroid diabe...

journal_title：Endocrine

authors： Moura Neto A,Parisi MC,Alegre SM,Pavin EJ,Tambascia MA,Zantut-Wittmann DE

更新日期：2016-01-01 00:00:00

abstract：:Ovulation and conversion of the follicle into the corpus luteum involve remarkable changes in vascular permeability and neovascularization of the luteinizing granulosa layer. To evaluate the importance of these vascular events in follicle rupture and luteal development, sequential experiments were designed in which ve...

journal_title：Endocrine

authors： Hazzard TM,Rohan RM,Molskness TA,Fanton JW,D'Amato RJ,Stouffer RL

更新日期：2002-04-01 00:00:00

abstract：:Studies designed to evaluate the short-term effects of incretin-related drugs in subjects with cardiac disease are still preliminary. In patients with heart failure, two of five studies showed that glucagon-like peptide-1 (GLP-1) infusion was associated with an absolute increase in left ventricular ejection fraction (...

journal_title：Endocrine

authors： Mikhail N

更新日期：2014-09-01 00:00:00