当前位置： SCI文献检索 > ENDOCRINE期刊下所有文献 > p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration.

p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration.

Abstract：

:Thymic carcinoid is an important component of the tumor spectrum causing Ectopic ACTH Syndrome (EAS) and usually carries a poor prognosis. Efforts have been focused on exploring the mechanism of the excessive ACTH production in non-pituitary tumors, whereas few studies have reported the molecular events underlying the tumor progression. In this study, seven patients with ACTH producing thymic carcinoids were enrolled. Of note is that five of them showed either lymph node metastasis, local invasion or distant metastasis. By using cDNA profiling approach, we evaluated the expression of cell adhesion pathway genes and found a remarkable overexpression of p21-activated kinase 3 (PAK3) in all thymic carcinoids which was further confirmed at both transcriptional and translational level. RAC1, an upstream activator of PAK3, was also overexpressed in thymic carcinoids. Overexpression of PAK3 in NIH3T3 cell enhanced cell migration and invasion. Importantly, we observed c-Jun NH(2)-terminal kinase (JNK) was activated in PAK3 transfected cells, and inhibition of JNK activity by SP600125, a JNK pathway inhibitor, abolished PAK3 mediated cell migration. Activation of JNK pathway was also detected in thymic carcinoid with high level of PAK3 expression. Our findings suggested a potential role of PAK3 in the progression of ACTH-producing thymic carcinoid.

journal_name

Endocrine

journal_title

Endocrine

authors

Liu RX,Wang WQ,Ye L,Bi YF,Fang H,Cui B,Zhou WW,Dai M,Zhang J,Li XY,Ning G

doi

10.1007/s12020-010-9324-6

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

38-47

issue

1

eissn

1355-008X

issn

1559-0100

journal_volume

38

pub_type

杂志文章

相关文献

ENDOCRINE文献大全
  • Critical appraisal and systematic review of guidelines for perioperative diabetes management: 2011-2017.

    abstract：PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1786-y

    authors： Song X,Wang J,Gao Y,Yu Y,Zhang J,Wang Q,Ma X,Estille J,Jin X,Chen Y,Mu Y

    更新日期：2019-02-01 00:00:00

  • Thyroxine and treatment of hypothyroidism: seven decades of experience.

    abstract：:Hypothyroidism is one of the most common endocrine disorders, affecting as much as 10% of the global population. There is a rich cultural milieu of treatment history and interventions dating as far back as 2 millennia. Chinese cretins were treated with sheep thyroid in the 6th century. In 1890, transplanted animal thy...

    journal_title：Endocrine

    pub_type： 历史文章,杂志文章,评审

    doi：10.1007/s12020-019-02006-8

    authors： Mateo RCI,Hennessey JV

    更新日期：2019-10-01 00:00:00

  • Pituitary magnetic resonance imaging in Cushing's disease.

    abstract：:Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-016-1038-y

    authors： Vitale G,Tortora F,Baldelli R,Cocchiara F,Paragliola RM,Sbardella E,Simeoli C,Caranci F,Pivonello R,Colao A,A.B.C. Group.

    更新日期：2017-03-01 00:00:00

  • A case of Riedel's thyroiditis with pleural and pericardial effusions.

    abstract：:Riedel's thyroiditis (RT) is a rare type of chronic thyroiditis of unproven etiology and definite treatment. It can be associated with retroperitoneal, mediastinal, orbital, and hepatic fibrosis. Symptoms arise mainly due to compression of neighboring structures. Surgery is usually required for a definite diagnosis an...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-009-9168-0

    authors： Erdoğan MF,Anil C,Türkçapar N,Ozkaramanli D,Sak SD,Erdoğan G

    更新日期：2009-06-01 00:00:00

  • Gonadotropin-releasing hormone receptor gene expression in rat anterior pituitary.

    abstract：:Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02782760

    authors： Mertani HC,Testart C,Ouhtit A,Brisson C,Morel G

    更新日期：1996-04-01 00:00:00

  • Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway.

    abstract：:Insulin resistance in skeletal muscle is a key feature in the pathogenesis of type 2 diabetes (T2D) that often manifests early in its development. Pharmaceutical and dietary strategies have targeted insulin resistance to control T2D, and many natural products with excellent pharmacological properties are good candidat...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-015-0599-5

    authors： Shi L,Zhang T,Zhou Y,Zeng X,Ran L,Zhang Q,Zhu J,Mi M

    更新日期：2015-11-01 00:00:00

  • Epithelial-to-mesenchymal transition in thyroid cancer: a comprehensive review.

    abstract：:The Metastatic progression of solid tumors, such as thyroid cancer is a complex process which involves various factors. Current understanding on the role of epithelial-mesenchymal transition (EMT) in thyroid carcinomas suggests that EMT is implicated in the progression from follicular thyroid cancer (FTC) and papillar...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-019-02030-8

    authors： Shakib H,Rajabi S,Dehghan MH,Mashayekhi FJ,Safari-Alighiarloo N,Hedayati M

    更新日期：2019-12-01 00:00:00

  • Cross-talk and modulation of signaling between somatostatin and growth factor receptors.

    abstract：:The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GP...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-011-9524-8

    authors： Kumar U

    更新日期：2011-10-01 00:00:00

  • Glucocorticoids curtail stimuli-induced CREB phosphorylation in TRH neurons through interaction of the glucocorticoid receptor with the catalytic subunit of protein kinase A.

    abstract：PURPOSE:Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS:Immunohistochem...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1223-z

    authors： Sotelo-Rivera I,Cote-Vélez A,Uribe RM,Charli JL,Joseph-Bravo P

    更新日期：2017-03-01 00:00:00

  • Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines.

    abstract：:Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-009-9288-6

    authors： Hernández-Hernández OT,Rodríguez-Dorantes M,González-Arenas A,Camacho-Arroyo I

    更新日期：2010-02-01 00:00:00

  • Pharmacokinetics, safety, and efficacy of DPP-4 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes mellitus and renal or hepatic impairment. A systematic review of the literature.

    abstract：:Renal or hepatic impairment, often encountered in patients with type 2 diabetes, influences the pharmacokinetics and bioavailability of antihyperglycemic agents. An emerging concern is whether pharmacotherapy with incretin-based agents, the most recent drug classes to be introduced for type 2 diabetes, can be safely u...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-014-0179-0

    authors： Giorda CB,Nada E,Tartaglino B

    更新日期：2014-08-01 00:00:00

  • In vitro and in vivo inhibition of mTOR by 1,25-dihydroxyvitamin D3 to improve early diabetic nephropathy via the DDIT4/TSC2/mTOR pathway.

    abstract：:We investigated whether 1,25-dihydroxy-vitamin D3 (1,25(OH)2D3) could improve early diabetic nephropathy through the DNA-damage-inducible transcript 4/tuberous sclerosis 2/mammalian target of rapamycin pathway. Rat mesangial cells were cultured in media containing normal glucose or high glucose and were treated with o...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-0999-1

    authors： Wang H,Wang J,Qu H,Wei H,Ji B,Yang Z,Wu J,He Q,Luo Y,Liu D,Duan Y,Liu F,Deng H

    更新日期：2016-11-01 00:00:00

  • Treatment of adult growth hormone deficiency with human recombinant growth hormone: an update on current evidence and critical review of advantages and pitfalls.

    abstract：:Adult-onset growth-hormone (GH) deficiency (GHD) is a rare disorder, which most commonly results from pituitary or peripituitary tumors and their treatment, and is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral density, cardiovascular risk profile and quality of life,...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-017-1492-1

    authors： Ramos-Leví AM,Marazuela M

    更新日期：2018-05-01 00:00:00

  • Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature.

    abstract：:PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease ...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-014-0440-6

    authors： Kandathil A,Wong KK,Wale DJ,Zatelli MC,Maffione AM,Gross MD,Rubello D

    更新日期：2015-05-01 00:00:00

  • Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain.

    abstract：:The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02994449

    authors： Hunt N,Willey KP,Abend N,Balvers M,Jähner D,Northemann W,Ivell R

    更新日期：1995-03-01 00:00:00

  • (99m)Tc-HYNIC-TOC scintigraphy in evaluation of active Graves' ophthalmopathy (GO).

    abstract：OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...

    journal_title：Endocrine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12020-007-0039-2

    authors： Sun H,Jiang XF,Wang S,Chen HY,Sun J,Li PY,Ning G,Zhao YJ

    更新日期：2007-06-01 00:00:00

  • New technologies aiding dietary programmes for weight control: the oral glucose spray.

    abstract：:To determine whether the administration of small amounts of glucose through an oral spray device (GSD) facilitates weight loss in overweight/obese subjects involved in a lifestyle modification programme. We randomly assigned 56 overweight/obese subjects to either the treatment group (n = 32) or the control group (n = ...

    journal_title：Endocrine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12020-013-9987-x

    authors： Khazrai YM,Maddaloni E,Altomare M,Cacciapaglia F,Pozzilli P

    更新日期：2014-03-01 00:00:00

  • Polymorphisms in NR3C1 gene associated with risk of metabolic syndrome in a Chinese population.

    abstract：:Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be associated with altered glucocorticoids sensitivity and changes in body composition and metabolic parameters. This study explored the relationship between single nucleotide polymorphisms (SNPs) of the NR3C1 gene and metabolic syndrome (...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0324-9

    authors： Yan YX,Dong J,Zhang J,Liu F,Wang W,Zhang L,He Y

    更新日期：2014-12-01 00:00:00

  • Long-term safety of long-acting octreotide in patients with diabetic retinopathy: results of pooled data from 2 randomized, double-blind, placebo-controlled phase 3 studies.

    abstract：PURPOSE:Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controll...

    journal_title：Endocrine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12020-017-1448-5

    authors： Pivonello R,Muscogiuri G,Holder G,Paul M,Sarp S,Lesogor A,Jordaan P,Eisinger J,Colao A

    更新日期：2018-04-01 00:00:00

  • Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors.

    abstract：:The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF02738959

    authors： Martí O,Martín M,Gavaldà A,Giralt M,Hidalgo J,Hsu BR,Kuhn RW,Armario A

    更新日期：1997-04-01 00:00:00

  • The impact of peri-operative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures.

    abstract：BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1398-y

    authors： El-Sibai K,Rajpal A,Al-Aridi R,Selman WR,Arafah BM

    更新日期：2017-10-01 00:00:00

  • Surgical biopsies in patients with central diabetes insipidus and thickened pituitary stalks.

    abstract：:Thickened pituitary stalks (TPSs) on magnetic resonance imaging (MRI) result from diverse pathologies; therefore, it is essential to make specific diagnoses for clinical decision-making. The diagnoses and indications for surgical biopsies in patients with central diabetes insipidus (CDI) and TPSs are thoroughly discus...

    journal_title：Endocrine

    pub_type： 信件

    doi：10.1007/s12020-014-0184-3

    authors： Jian F,Bian L,Sun S,Yang J,Chen X,Chen Y,Ma Q,Miao F,Wang W,Ning G,Sun Q

    更新日期：2014-09-01 00:00:00

  • Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta).

    abstract：:RF amide peptide family with distinctive terminal -Arg-Phe-NH(2) signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebrates including influencing pituitary hormone secretion. More recently, two members of this fa...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-012-9672-5

    authors： Qaiser F,Wahab F,Wiqar MA,Hashim R,Leprince J,Vaudry H,Tena-Sempere M,Shahab M

    更新日期：2012-12-01 00:00:00

  • Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets.

    abstract：:The expression and activities of constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) in relation to insulin and glucagon secretory mechanisms were investigated in islets isolated from rats subjected to total parenteral nutrition (TPN) for 10 d. TPN is known to result in significantly i...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:16:2:097

    authors： Salehi A,Ekelund M,Henningsson R,Lundquist I

    更新日期：2001-11-01 00:00:00

  • MassARRAY-based simultaneous detection of hotspot somatic mutations and recurrent fusion genes in papillary thyroid carcinoma: the PTC-MA assay.

    abstract：PURPOSE:We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1483-2

    authors： Pesenti C,Muzza M,Colombo C,Proverbio MC,Farè C,Ferrero S,Miozzo M,Fugazzola L,Tabano S

    更新日期：2018-07-01 00:00:00

  • Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen.

    abstract：:The original neuroprotective hypothesis of estrogen was based on the gender difference in brain response to the ischemia-reperfusion injury. Additional clinical reports also suggest that estrogen may improve cognition in patients with Alzheimer disease. 17beta-Estradiol is the most potent endogenous ligand of estrogen...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1385/endo:21:1:27

    authors： Chiueh C,Lee S,Andoh T,Murphy D

    更新日期：2003-06-01 00:00:00

  • Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.

    abstract：:Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-termina...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-008-9141-3

    authors： Gruber KA,Fan W,Akerberg H,Larhammar D,Chee MJ,Colmers WF,Cone RD

    更新日期：2009-06-01 00:00:00

  • Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease.

    abstract：:The aim of this study is to investigate the correlation between serum microRNA-217 and the severity of diabetic kidney disease determined by albuminuria. Four hundred ninety five type 2 diabetes patients were divided into three groups: normoalbuminuric group, microalbuminuric group, and macroalbuminuric group. Serum m...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1069-4

    authors： Shao Y,Ren H,Lv C,Ma X,Wu C,Wang Q

    更新日期：2017-01-01 00:00:00

  • Novel mutation of PPOX gene in a patient with abdominal pain and syndrome of inappropriate antidiuresis.

    abstract：PURPOSE:Acute porphyrias are metabolic disorders of heme biosynthesis characterized by acute life-threatening attacks. The diagnosis is often missed since clinical presentation is aspecific mimicking other medical and surgical conditions. Variegate porphyria (VP) is an autosomal dominant inherited disease with incomple...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1569-5

    authors： Tabaro I,Reimondo G,Osella G,Aurizi C,Caraci P,Barbieri L,Giachino DF,Sirchia F,Terzolo M

    更新日期：2018-09-01 00:00:00

  • Ovarian transcriptomes as a tool for a global approach of genes modulated by gonadotropic hormones in human ovarian granulosa cells.

    abstract：:Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1385/endo:26:3:259

    authors： Friedmann S,Dantes A,Amsterdam A

    更新日期：2005-04-01 00:00:00