In vitro and in vivo inhibition of mTOR by 1,25-dihydroxyvitamin D3 to improve early diabetic nephropathy via the DDIT4/TSC2/mTOR pathway.

abstract：:A great number of prospective studies have investigated the relationship between leisure time physical activity (LTPA) and metabolic syndrome (MetS) risk. However, the results have been inconsistent. The aim of this study was to clarify the relationship between LTPA and MetS risk. Literature databases were searched in...

journal_title：Endocrine

authors： He D,Xi B,Xue J,Huai P,Zhang M,Li J

更新日期：2014-06-01 00:00:00

abstract：:The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T...

journal_title：Endocrine

authors： Ozdemir S,Yücel R,Dariyerli N,Toplan S,Akyolcu MC,Yigit G,Hatemi H

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To compare long-term outcomes in patients with adrenal incidentalomas (AIs) with the response to a 1 mg overnight dexamethasone suppression test (DST). METHODS:Consecutive patients with "non-functional" AIs (n = 365) were examined. Patients with overt hormone excess, adrenocortical cancer and known malignancy ...

journal_title：Endocrine

authors： Patrova J,Kjellman M,Wahrenberg H,Falhammar H

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION AND AIM:Hyperprolactinaemia in pregnancy leads to mild and reversible changes in the maternal skeletal system, and medicamentous hyperprolactinemia causes more detrimental effects. We conducted an experimental study to evaluate differences between Prlr gene expression in the duodenum, vertebrae and kidneys...

journal_title：Endocrine

authors： Radojkovic D,Pesic M,Radojkovic M,Dimic D,Vukelic Nikolic M,Jevtovic Stoimenov T,Radenkovic S,Velojic Golubovic M,Radjenovic Petkovic T,Antic S

更新日期：2018-12-01 00:00:00

abstract：:Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations. Given that the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity and type 2 diabetes, we hypothesize that the common rs9939609 varia...

journal_title：Endocrine

authors： Yan Q,Hong J,Gu W,Zhang Y,Liu Q,Su Y,Zhang Y,Li X,Cui B,Ning G

更新日期：2009-12-01 00:00:00

abstract：:Succinic acid esters are currently under investigation as possible insulinotropic tools in the treatment of noninsulin-dependent diabetes mellitus. The present article introduces three novel nutrient esters and aims mainly to explore, in both normal and GK rats, the secretory response to such esters when tested alone ...

journal_title：Endocrine

authors： Sener A,Kadiata MM,Ladrière L,Malaisse WJ

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Patients with cortisol secreting adrenal adenomas present with Cushing's syndrome (CS), while 5-15% of subjects with adrenal incidentalomas have subclinical hypercortisolism (SH) as they have biochemical abnormalities suggesting autonomous cortisol secretion without associated clinical features of CS. GOALS...

journal_title：Endocrine

authors： Khawandanah D,ElAsmar N,Arafah BM

更新日期：2019-01-01 00:00:00

abstract：:Hypothyroidism is one of the most common endocrine disorders, affecting as much as 10% of the global population. There is a rich cultural milieu of treatment history and interventions dating as far back as 2 millennia. Chinese cretins were treated with sheep thyroid in the 6th century. In 1890, transplanted animal thy...

journal_title：Endocrine

authors： Mateo RCI,Hennessey JV

更新日期：2019-10-01 00:00:00

abstract：:We validated the effect of prolactin-releasing peptide (PrRP) on prolactin (PRL) secretion from rat anterior pituitary cells in in vitro culture. We found that culture conditions considerably influenced the response of the anterior pituitary cells to PrRP. Longer culture term (4 d) was required to obtain better respon...

journal_title：Endocrine

authors： Kawamata Y,Fujii R,Fukusumi S,Habata Y,Hosoya M,Hinuma S,Kitada C,Onda H,Nishimura O,Fujino M

更新日期：2000-06-01 00:00:00

abstract：:For analyzing the changes in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence of fever associated with the it. The study included 11 subj...

journal_title：Endocrine

authors： Aydin S,Guven T,Sahin İ,Aksoy A,Kendir Y,İlhan MN,Citil C,Catak Z,Ustun C

更新日期：2012-10-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...

journal_title：Endocrine

authors： Mertani HC,Testart C,Ouhtit A,Brisson C,Morel G

更新日期：1996-04-01 00:00:00

abstract：:Variants of growth hormone (GH) are present in most vertebrates. Chicken GH (cGH) undergoes posttranslational modifications that contribute to its structural diversity. Although the 22-kDa form of GH is the most abundant, some other variants have discrete bioactivities that may not be shared by others. The proportion ...

journal_title：Endocrine

authors： Martínez-Coria H,López-Rosales LJ,Carranza M,Berumen L,Luna M,Arámburo C

更新日期：2002-03-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinica...

journal_title：Endocrine

authors： Kurtulmus N,Mert M,Tanakol R,Yarman S

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. SUBJECT AND RESULTS:A patient with CDC73-associated metastatic parathyroid carcinoma was...

journal_title：Endocrine

authors： Sarquis M,Marx SJ,Beckers A,Bradwell AR,Simonds WF,Bicalho MAC,Daly AF,Betea D,Friedman E,De Marco L

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:In the general population, sleep disorders are associated with an increased risk of cognitive impairment. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have additional risk of cognitive impairment due to acromegaly treatmen...

journal_title：Endocrine

authors： Wennberg A,Lorusso R,Dassie F,Benavides-Varela S,Parolin M,De Carlo E,Fallo F,Mioni R,Vettor R,Semenza C,Maffei P

更新日期：2019-12-01 00:00:00

abstract：:Environmental toxicants are thought to play a role in several estrogen-dependent diseases including breast cancer and endometriosis. Toxicant-induced increased aromatase activity, an enzyme complex that catalyzes the final rate-limiting step in the conversion of androgens to estrogens, has been reported in assays usin...

journal_title：Endocrine

authors： Holloway AC,Stys KA,Foster WG

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dopamine agonist (DA)-resistant prolactinomas are rare but they constitute a real challenge, since there are few therapeutic alternatives left for these patients. DESIGN AND SETTING:Proof-of-concept study at a tertiary care, referral center. PATIENTS AND METHODS:The studied population consis...

journal_title：Endocrine

authors： Sosa-Eroza E,Espinosa E,Ramírez-Rentería C,Mendoza V,Arreola R,Mercado M

更新日期：2018-08-01 00:00:00

abstract：:Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...

journal_title：Endocrine

authors： Ryan DH

更新日期：2000-10-01 00:00:00

abstract：:In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...

journal_title：Endocrine

authors： Kojima C,Kondo M,Jin W,Shimizu K,Itoh M,Watanabe G,Groome NP,Taya K

更新日期：2002-06-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease, characterized by cutaneous and multi-organ fibrosis, and vascular abnormalities. Skin thickening is a characteristic feature of SSc and resembles myxedematous skin. Our aim was to correlate the degree of skin involvement in SSc patients with serum TSH levels, si...

journal_title：Endocrine

authors： Bagnato GL,Roberts WN,Fiorenza A,Arcuri C,Certo R,Trimarchi F,Ruggeri RM,Bagnato GF

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:to assess bone damage and metabolic abnormalities in patients with Addison's disease given replacement doses of glucocorticoids and mineralocorticoids. METHODS:A total of 87 patients and 81 age-matched and sex-matched healthy controls were studied. The following parameters were measured: urinary cortisol, seru...

journal_title：Endocrine

authors： Camozzi V,Betterle C,Frigo AC,Zaccariotto V,Zaninotto M,De Caneva E,Lucato P,Gomiero W,Garelli S,Sabbadin C,Salvà M,Costa MD,Boscaro M,Luisetto G

更新日期：2018-02-01 00:00:00

abstract：:To investigate a possible neurotropic role for thyrotropin-releasing hormone (TRH) in the central nervous system, we used recombinant antisense TRH adenovirus (TRHav) to "knock out" TRH in cultured 17-d fetal rat diencephalon. The morphology along with beta-galactosidase (beta-gal) enzyme histochemistry (X-gal stainin...

journal_title：Endocrine

authors： Luo LG,Lee SL,Lechan RM,Jackson IM

更新日期：2001-06-01 00:00:00

abstract：:The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...

journal_title：Endocrine

authors： Qiu H,Tang W,Yin P,Cheng F,Wang L

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:This study aimed to evaluate the effectiveness of ultrasound (US)-guided radiofrequency ablation (RFA) treatment of benign thyroid nodules in consecutive large number series. To find out whether there is any difference according to the nature of the nodules, nodules were subdivided into two groups of predominan...

journal_title：Endocrine

authors： Lee GM,You JY,Kim HY,Chai YJ,Kim HK,Dionigi G,Tufano RP

更新日期：2019-05-01 00:00:00

abstract：:Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...

journal_title：Endocrine

authors： Ding Y,Zou R,Judd RL,Zhong J

更新日期：2006-08-01 00:00:00

abstract：:FKBP5 encodes a co-chaperone of HSP90 protein that regulates intracellular glucocorticoid receptor sensitivity. When it is bound to the glucocorticoid receptor complex, cortisol binds with lower affinity to glucocorticoid receptor. Cushing's syndrome is associated with memory deficits, smaller hippocampal volumes, and...

journal_title：Endocrine

authors： Resmini E,Santos A,Aulinas A,Webb SM,Vives-Gilabert Y,Cox O,Wand G,Lee RS

更新日期：2016-12-01 00:00:00

abstract：:The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

journal_title：Endocrine

authors： Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

更新日期：2013-04-01 00:00:00

abstract：:The objective was to determine molecular genetic analysis of the TPO gene in Turkish children with iodide organification defect (IOD). Patients with a diagnosis of primary hypothyroidism were evaluated. Subjects having a definite diagnosis of autoimmune thyroiditis, thyroid gland dysplasia and, or iodine deficiency we...

journal_title：Endocrine

authors： Turkkahraman D,Alper OM,Pehlivanoglu S,Aydin F,Yildiz A,Luleci G,Akcurin S,Bircan I

更新日期：2010-02-01 00:00:00

abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...

journal_title：Endocrine

authors： Sandhoff TW,McLean MP

更新日期：1996-10-01 00:00:00

abstract：:It is well known that TSH plays a major role in the secretion of thyroid hormones, maintenance of thyroid specific gene expression, and gland growth. In this study, we aimed to evaluate association between tests of thyroid functions (fT3, fT4, TSH) and differentiated thyroid carcinoma. 441 patients operated for nodula...

journal_title：Endocrine

authors： Gul K,Ozdemir D,Dirikoc A,Oguz A,Tuzun D,Baser H,Ersoy R,Cakir B

更新日期：2010-04-01 00:00:00