当前位置： SCI文献检索 > ENDOCRINE期刊下所有文献 > High-normal 2 h glucose is associated with defects of insulin secretion and predispose to diabetes in Chinese adults.

High-normal 2 h glucose is associated with defects of insulin secretion and predispose to diabetes in Chinese adults.

Abstract：

:The purpose of the study was to determine whether impaired beta-cell function exists in Chinese individuals within the normal range of glucose tolerance (NGT), and these individuals are predisposed to diabetes later in life. The cross-sectional study included 843 NGT subjects and 562 isolated impaired glucose tolerance (IGT) patients and the longitudinal study included 1,724 NGT subjects. Insulin secretion was assessed using indices derived from oral glucose tolerance test and adjusted by insulin resistance. NGT subjects were sub-divided into two groups: NGT-l (2hPG<125 mg/dl) and NGT-h (2hPG 125-140 mg/dl). Normal weight subjects were individuals with BMI<25 kg/m2, and overweight were with BMI≥25 kg/m2. In normal weight subjects, the first- and second-phase insulin secretion indices were significantly higher in NGT-h and NGT-l subjects compared with IGT subjects. However, in overweight subjects, first-phase insulin secretion index in NGT-h subjects was significantly lower than that in NGT-l subjects, but similar to that in IGT patients. The second-phase insulin secretion was comparable between NGT-h and NGT-l subjects. After an average follow-up of 43.80±11.25 months, totally 25 (1.5%) NGT subjects at baseline developed diabetes. The incidence rate of diabetes was higher in NGT-h overweight subjects (9.2%) than in NGT-l overweight subjects (1.5%) with a risk ratio (RR) reaching 6.655 [95% confidence interval (CI) 2.347-18.867]. This risk remained after adjustment for sex, age, BMI, systolic pressure, and diastolic pressure (RR 8.315, 95% CI 2.649-26.108). It is concluded that overweight NGT adults with high-normal 2hPG (≥125 mg/dl) had a defect in first-phase insulin secretion and were with the increasing risk for developing new diabetes.

journal_name

Endocrine

journal_title

Endocrine

authors

Lin Z,Zhou J,Li X,Song L,Hou X,Tang J,Wang C,Jia W

doi

10.1007/s12020-014-0244-8

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

179-86

issue

1

eissn

1355-008X

issn

1559-0100

journal_volume

48

pub_type

杂志文章

相关文献

ENDOCRINE文献大全
  • The effect of aromatase inhibition on the sexual differentiation of the sheep brain.

    abstract：:This study tested the hypothesis that aromatization of testosterone to estradiol is necessary for sexual differentiation of the sheep brain. Pregnant ewes (n = 10) were treated with the aromatase inhibitor 1,4,6- androstatriene-3,17-dione (ATD) during the period of gestation when the sheep brain is maximally sensitive...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:29:3:501

    authors： Roselli CE,Schrunk JM,Stadelman HL,Resko JA,Stormshak F

    更新日期：2006-06-01 00:00:00

  • Recombinant human thyrotropin versus thyroid hormone withdrawal in an Asian population.

    abstract：CONTEXT:To prepare for radioactive iodine therapy in post total thyroidectomy patients with well-differentiated thyroid cancer (WDTC), either thyroid hormone withdrawal (THW) or administration of recombinant human thyrotropin (rhTSH) can be performed. OBJECTIVE:Our objective is to compare quality of life (QoL) paramet...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02238-z

    authors： Tang CYL,Thang SP,Zaheer S,Kwan CK,Ng DC

    更新日期：2020-07-01 00:00:00

  • Polymorphisms in NR3C1 gene associated with risk of metabolic syndrome in a Chinese population.

    abstract：:Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be associated with altered glucocorticoids sensitivity and changes in body composition and metabolic parameters. This study explored the relationship between single nucleotide polymorphisms (SNPs) of the NR3C1 gene and metabolic syndrome (...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0324-9

    authors： Yan YX,Dong J,Zhang J,Liu F,Wang W,Zhang L,He Y

    更新日期：2014-12-01 00:00:00

  • A case of Riedel's thyroiditis with pleural and pericardial effusions.

    abstract：:Riedel's thyroiditis (RT) is a rare type of chronic thyroiditis of unproven etiology and definite treatment. It can be associated with retroperitoneal, mediastinal, orbital, and hepatic fibrosis. Symptoms arise mainly due to compression of neighboring structures. Surgery is usually required for a definite diagnosis an...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-009-9168-0

    authors： Erdoğan MF,Anil C,Türkçapar N,Ozkaramanli D,Sak SD,Erdoğan G

    更新日期：2009-06-01 00:00:00

  • Recycling processes of cellular ascorbate generate oxidative stress in pancreatic tissues in in vitro system.

    abstract：:Ascorbate is a reducing agent, which is also known to oxidize cellular components. Our proposed mechanism of the oxidative action is as follows: Ascorbate is concentrated in the pancreas and is leaked in adverse conditions, and oxidized to dehydroascorbate. The dehydroascorbate is carried into cells by a glucose trans...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:18:1:91

    authors： Brown S,Georgatos M,Reifel C,Song JH,Shin SH,Hong M

    更新日期：2002-06-01 00:00:00

  • Sex differences in COVID-19: the role of androgens in disease severity and progression.

    abstract：PURPOSE:Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influe...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-020-02536-6

    authors： Mohamed MS,Moulin TC,Schiöth HB

    更新日期：2021-01-01 00:00:00

  • Prolactin-regulated apoptosis of Nb2 lymphoma cells: pim-1, bcl-2, and bax expression.

    abstract：:Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:9:2:163

    authors： Krumenacker JS,Buckley DJ,Leff MA,McCormack JT,de Jong G,Gout PW,Reed JC,Miyashita T,Magnuson NS,Buckley AR

    更新日期：1998-10-01 00:00:00

  • Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis.

    abstract：:We performed a meta-analysis to analyze the associations of depression with pre-diabetes (PreDM), undiagnosed diabetes (UDM), and previously diagnosed diabetes (PDM), and whether the association was affected by important study characteristics. We searched relevant articles published in PubMed and EMBASE up to August, ...

    journal_title：Endocrine

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12020-016-0869-x

    authors： Chen S,Zhang Q,Dai G,Hu J,Zhu C,Su L,Wu X

    更新日期：2016-07-01 00:00:00

  • Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFbeta1, bFGF, and EGF.

    abstract：:Pituitary tumors are highly vascular neoplasms, which suggest an important role of angiogenesis in pituitary tumor growth. We used the human pituitary cell line (HP75) to examine the effects of the growth factors TGFbeta1, bFGF, and EGF on cell growth, and on the regulation of the pro-angiogenic growth factor VEGF-A a...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:24:2:141

    authors： Horiguchi H,Jin L,Ruebel KH,Scheithauer BW,Lloyd RV

    更新日期：2004-07-01 00:00:00

  • Complement action on secretory cells identified by the reverse hemolytic plaque assay: modified assay eliminates exposure of secretory cells to complement.

    abstract：:The application of a hemolytic plaque assay to antigen-secreting endocrine cells has brought about great advances in the study of regulation of hormone secretion. The reverse hemolytic plaque assay (RHPA) has enabled quantitation of secretion at the single cell level with simultaneous analysis of the population respon...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/BF03021421

    authors： Gregerson KA

    更新日期：1995-05-01 00:00:00

  • Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis.

    abstract：:Subacute thyroiditis is a transient inflammatory thyroid disease of unknown etiology. The primary goal for treatment is to mitigate inflammation. The aim of this retrospective study was to compare the therapeutic effects of prednisolone and nonsteroidal anti-inflammation drugs in patients with subacute thyroiditis. In...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1122-3

    authors： Sato J,Uchida T,Komiya K,Goto H,Takeno K,Suzuki R,Honda A,Himuro M,Watada H

    更新日期：2017-01-01 00:00:00

  • Is autoimmune thyroiditis a risk factor for early atherosclerosis in premenopausal women even if in euthyroid status?

    abstract：:Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-012-9842-5

    authors： Topaloglu O,Gokay F,Kucukler K,Burnik FS,Mete T,Yavuz HC,Berker D,Guler S

    更新日期：2013-08-01 00:00:00

  • Osteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome.

    abstract：:Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they co...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/s12020-014-0357-0

    authors： Bruyère O,Reginster JY

    更新日期：2015-02-01 00:00:00

  • The impact of peri-operative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures.

    abstract：BACKGROUND:Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alteratio...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1398-y

    authors： El-Sibai K,Rajpal A,Al-Aridi R,Selman WR,Arafah BM

    更新日期：2017-10-01 00:00:00

  • Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells.

    abstract：PURPOSE:The influence of the dipeptidyl peptidase-IV inhibitor, gemigliptin alone or in combination with metformin on survival, proliferation, and migration of thyroid carcinoma cells was investigated. METHODS:SW1736 and TPC-1 human thyroid carcinoma cells were used. RESULTS:Gemigliptin and metformin caused cell deat...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-017-1503-2

    authors： Kim SH,Kang JG,Kim CS,Ihm SH,Choi MG,Yoo HJ,Lee SJ

    更新日期：2018-02-01 00:00:00

  • Testosterone differentially regulates targets of lipid and glucose metabolism in liver, muscle and adipose tissues of the testicular feminised mouse.

    abstract：:Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis and atherosclerosis. The testicular feminised mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-016-1019-1

    authors： Kelly DM,Akhtar S,Sellers DJ,Muraleedharan V,Channer KS,Jones TH

    更新日期：2016-11-01 00:00:00

  • Comparison of F-18 FDG-PET/CT and Tc-99m MIBI in the preoperative evaluation of cold thyroid nodules in the same patient group.

    abstract：:Recent studies have reported that standardized uptake values of FDG-PET imaging might predict malignant thyroid nodules and can be used in the preoperative evaluation of thyroid lesions. The aim of our study was to evaluate FDG-PET imaging in patients with cold thyroid nodules and to compare the imaging findings with ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-015-0580-3

    authors： Sager S,Vatankulu B,Erdogan E,Mut S,Teksoz S,Ozturk T,Sonmezoglu K,Kanmaz B

    更新日期：2015-09-01 00:00:00

  • Metabolic syndrome and the risk of cardiovascular complications in young patients with different phenotypes of polycystic ovary syndrome.

    abstract：PURPOSE:Insulin resistance is an important factor in the pathogenesis of polycystic ovary syndrome (PCOS), which is associated with higher risk of metabolic syndrome (MetS) and cardiovascular complications. Early atherosclerotic lesions may be diagnosed by ultrasonographic parameters: brachial artery flow-mediated dila...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02596-8

    authors： Krentowska A,Łebkowska A,Jacewicz-Święcka M,Hryniewicka J,Leśniewska M,Adamska A,Kowalska I

    更新日期：2021-01-13 00:00:00

  • An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter.

    abstract：OBJECTIVES:Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the p...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1701-6

    authors： Aydoğan Y,Altay M,Ünsal O,Kaplanoğlu V,Çağır Y,Yıldız C,Beyan E,Ramadan SU

    更新日期：2018-11-01 00:00:00

  • Exosomal microRNA-29a mediates cardiac dysfunction and mitochondrial inactivity in obesity-related cardiomyopathy.

    abstract：PURPOSE:Present study aims to explore the pathophysiological role of microRNA (miR)-29a in the process of obesity-related cardiomyopathy in human subjects and mice. METHODS:The expression level of circulating exosomal miR-29a was measured in 37 lean and 30 obese human subjects, and correlated with cardiac parameters. ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-018-1753-7

    authors： Li F,Zhang K,Xu T,Du W,Yu B,Liu Y,Nie H

    更新日期：2019-03-01 00:00:00

  • 68Ga-DOTANOC and 18F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers.

    abstract：OBJECTIVE:Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT perfo...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-019-01846-8

    authors： Souteiro P,Gouveia P,Ferreira G,Belo S,Costa C,Carvalho D,Duarte H,Sampaio IL

    更新日期：2019-05-01 00:00:00

  • Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC).

    abstract：:The familial forms of non-medullary thyroid carcinoma (FNMTC) represent approximately 5 % of thyroid neoplasms. Nine FNMTC susceptibility loci have been mapped; however, only the DICER1 and SRGAP1 susceptibility genes have been identified. The transcription factors NKX2-1, FOXE1, PAX8, and HHEX are involved in the mor...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-014-0470-0

    authors： Pereira JS,da Silva JG,Tomaz RA,Pinto AE,Bugalho MJ,Leite V,Cavaco BM

    更新日期：2015-05-01 00:00:00

  • Hyperthermal liquid, spray, and smog may be potential risk factors for recurrent laryngeal nerve thermal injury during thyroid surgeries.

    abstract：PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-020-02451-w

    authors： Yu X,Liu C,Yan M,Gong W,Wang Y

    更新日期：2020-08-10 00:00:00

  • Vasopressin, oxytocin, corticotrophin-releasing factor, and sodium responses during fluoxetine administration in the rat.

    abstract：:Hyponatremia has been observed in elderly patients treated with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. The pathogenesis of this effect is not known, but enhanced release of vasopressin (VP) and its renal actions may be a possible mechanism. Excess secretion of VP in combination with large fluid ...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:8:1:13

    authors： Marar IE,Amico JA

    更新日期：1998-02-01 00:00:00

  • Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats.

    abstract：:Progesterone is a steroid which regulates neural function, thereby modulating neurotransmission, cell survival, and behavior. Previous studies by our group have shown that chronic administration of low doses of progesterone in diestrus II female rats has an antidepressant-like effect in the forced swimming test (FST)....

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-013-0126-5

    authors： Arbo BD,Andrade S,Osterkamp G,Gomez R,Ribeiro MF

    更新日期：2014-08-01 00:00:00

  • DDE-induced changes in aromatase activity in endometrial stromal cells in culture.

    abstract：:Environmental toxicants are thought to play a role in several estrogen-dependent diseases including breast cancer and endometriosis. Toxicant-induced increased aromatase activity, an enzyme complex that catalyzes the final rate-limiting step in the conversion of androgens to estrogens, has been reported in assays usin...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:27:1:045

    authors： Holloway AC,Stys KA,Foster WG

    更新日期：2005-06-01 00:00:00

  • Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans.

    abstract：:Remarkable decreases in growth hormone (GH) secretion accompany healthy aging. The pathophysiology of this hyposomatotropism is confounded by concurrent changes in body composition (with increased visceral fat), physiological declines in estrogen and androgen concentrations, differences in gender responses to aging, a...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1007/BF02778061

    authors： Veldhuis JD,Iranmanesh A,Weltman A

    更新日期：1997-08-01 00:00:00

  • Expression of interleukin-15 and inflammatory cytokines in skeletal muscles of STZ-induced diabetic rats: effect of resistance exercise training.

    abstract：:Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1007/s12020-013-0038-4

    authors： Molanouri Shamsi M,Hassan ZH,Gharakhanlou R,Quinn LS,Azadmanesh K,Baghersad L,Isanejad A,Mahdavi M

    更新日期：2014-05-01 00:00:00

  • Effects of endomorphin-1 on open-field behavior and on the hypothalamic-pituitary-adrenal system.

    abstract：:The effects of endomorphin-1 (EM1) on behavioral responses and on the hypothalamic-pituitary-adrenal system were investigated in mice. Locomotor activity was measured in an "open-field" apparatus, with parallel recording of the numbers of rearings and groomings. Different doses of the peptide (250 ng to 5 microg) were...

    journal_title：Endocrine

    pub_type： 杂志文章

    doi：10.1385/ENDO:14:2:221

    authors： Bujdosó E,Jászberényi M,Tömböly C,Tóth G,Telegdy G

    更新日期：2001-03-01 00:00:00

  • Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity.

    abstract：:Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...

    journal_title：Endocrine

    pub_type： 杂志文章,评审

    doi：10.1385/ENDO:13:2:193

    authors： Ryan DH

    更新日期：2000-10-01 00:00:00