Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells.

abstract：:Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administratio...

journal_title：Endocrine

authors： Engels K,Rakov H,Zwanziger D,Hönes GS,Rehders M,Brix K,Köhrle J,Möller LC,Führer D

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...

journal_title：Endocrine

authors： Wang S,Sun H,Chen HY,Zhao ZF,Yang Y,Zhao YJ,Cui B,Ning G

更新日期：2007-04-01 00:00:00

abstract：:The influence of thyroid hormones on cardiovascular system is well established. Thyroid diseases can effectively enhance the alteration on cardiovascular system by influencing chronotropic and inotropic actions of the heart; altering the strength and the speed of contraction, the speed of relaxation, the duration of t...

journal_title：Endocrine

authors： Scicchitano P,Dentamaro I,Tunzi F,Ricci G,Carbonara S,Devito F,Zito A,Ciampolillo A,Ciccone MM

更新日期：2016-12-01 00:00:00

abstract：:In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract...

journal_title：Endocrine

authors： Yang YS,Li XY,Hong J,Gu WQ,Zhang YF,Yang J,Song HD,Chen JL,Ning G

更新日期：2007-12-01 00:00:00

abstract：:Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...

journal_title：Endocrine

authors： Cetin C,Baş F,Uçar A,Poyrazoğlu S,Saka N,Bundak R,Darendeliler F

更新日期：2014-12-01 00:00:00

abstract：:Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+ concentration ([Ca2+]i), which is determined by Ca2+ influx and release from intracellular Ca2+ storage sites. Ca2+ influx...

journal_title：Endocrine

authors： Han X,Zhu Y,Zhao Y,Chen C

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Bilateral inferior petrosal sinus sampling (BIPSS) is useful for differential diagnosis of adult Cushing's disease (CD) but may not be so reliable in pediatric cases. The purpose of this study was to evaluate the sensitivity of BIPSS before and after desmopressin stimulation in pediatric CD, and to explore rela...

journal_title：Endocrine

authors： Chen S,Chen K,Lu L,Zhang X,Tong A,Pan H,Zhu H,Lu Z

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Diabetes self-management education is an essential part of diabetes care, but its impact on all-cause mortality risk of type 2 diabetes patients is unclear. A systematic review and meta-analysis aiming to elucidate the impact of diabetes self-management education on all-cause mortality risk of type 2 diabete...

journal_title：Endocrine

authors： He X,Li J,Wang B,Yao Q,Li L,Song R,Shi X,Zhang JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:A large number of studies has investigated proopiomelanocortin processing in anterior pituitary corticotropes but little is known on proopiomelanocortin/ACTH degradation within these cells. The ubiquitin-proteasome system is an intracellular protein degradation pathway which has garnered considerable interest i...

journal_title：Endocrine

authors： Sesta A,Cassarino MF,Cavagnini F,Pecori Giraldi F

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...

journal_title：Endocrine

authors： Low S,Khoo KCJ,Wang J,Irwan B,Sum CF,Subramaniam T,Lim SC,Wong TKM

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-anal...

journal_title：Endocrine

authors： Xia MY,Lou XH,Lin SJ,Wu ZB

更新日期：2018-01-01 00:00:00

abstract：:Leptin is an important hormone that has potent effects on appetite and body weight. The regulation of leptin gene expression and secretion by corticosteroids and insulin was studied in the rat. Adrenalectomy resulted in a significant reduction in leptin gene expression and secretion. The reduction was corrected by hor...

journal_title：Endocrine

authors： Tan JT,Patel BK,Kaplan LM,Koenig JI,Hooi SC

更新日期：1998-02-01 00:00:00

abstract：:Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia. Nowadays, IMA is accepted as a marker of oxidative stress. In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 dia...

journal_title：Endocrine

authors： Ukinc K,Eminagaoglu S,Ersoz HO,Erem C,Karahan C,Hacihasanoglu AB,Kocak M

更新日期：2009-12-01 00:00:00

abstract：:To determine whether the administration of small amounts of glucose through an oral spray device (GSD) facilitates weight loss in overweight/obese subjects involved in a lifestyle modification programme. We randomly assigned 56 overweight/obese subjects to either the treatment group (n = 32) or the control group (n = ...

journal_title：Endocrine

authors： Khazrai YM,Maddaloni E,Altomare M,Cacciapaglia F,Pozzilli P

更新日期：2014-03-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour which frequently occurs in the context of the multiple endocrine neoplasia syndromes, where it coexists with other usually benign tumours. The clinical picture varies and distant metastases are frequently present at diagnosis. Calcitonin levels are elevated in the pre...

journal_title：Endocrine

authors： Alevizaki M,Kyratzoglou E,Bamias A,Tzanela M,Dimopoulos MA,Saltiki K

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...

journal_title：Endocrine

authors： Sun H,Jiang XF,Wang S,Chen HY,Sun J,Li PY,Ning G,Zhao YJ

更新日期：2007-06-01 00:00:00

abstract：:The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

journal_title：Endocrine

authors： Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years. METHODS:A total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in ...

journal_title：Endocrine

authors： Hui Y,Wang J,An Y,Gong Q,Li H,Zhang B,Shuai Y,Chen Y,Hu Y,Li G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Hyponatremia is the most common electrolyte disorder in hospitalized patients, and its etiopathogenesis is related to an underlying tumor in 14% of cases. Hyponatremia has been associated with a worse outcome in several pathologies, including cancer, in which the leading cause of this electrolyte alteration is ...

journal_title：Endocrine

authors： Marroncini G,Fibbi B,Errico A,Grappone C,Maggi M,Peri A

更新日期：2020-02-01 00:00:00

abstract：:Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic cell-line, a model for endochondral ossification, were analyzed. For this purpose, real-time PCR, Western blot...

journal_title：Endocrine

authors： Ben-Eliezer M,Phillip M,Gat-Yablonski G

更新日期：2007-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Endocrine

authors： Poli R,Scatolini M,Grosso E,Maletta F,Gallo M,Liscia D,Nelva A,Cesario F,Forte G,Metovic J,Volante M,Arvat E,Papotti M

更新日期：2020-12-01 00:00:00

abstract：:Computer analysis of the human placental lactogen-B (hPL-B) enhancer reveals two putative binding sites for the transcription factor NF-IL6, but the role of NF-IL6 in the regulation of the enhancer is unknown. Using gel mobility shift and supershift assays, we demonstrated that NF-IL6 binds to both enhancer sites. Tra...

journal_title：Endocrine

authors： Brar AK,Richards RG,Cheng YH,Richardson B,Kanda Y,Handwerger S

更新日期：2000-02-01 00:00:00

abstract：:RU486 has been reported to be a glucocorticoid receptor (GR) and a progesterone receptor (PR) antagonist. We have analysed RU486 activity on the GR in WCL-2 (CHO) cells and in COS-7 cells transiently transfected with the mouse GR and with the reporter MMTVCAT (MCAT). These cell lines do not contain any active progeste...

journal_title：Endocrine

authors： Zhang S,Danielsen M

更新日期：1995-01-01 00:00:00

abstract：:Our aim was to evaluate the effectiveness of off-label use of sunitinib in patients with advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAI) therapy. We performed a retrospective analysis of patients treated in the setting of clinical practice in a University General Hospital. Eleven...

journal_title：Endocrine

authors： Díez JJ,Iglesias P,Alonso T,Grande E

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved. METHODS:The patient group comprised 200 children with CHI that were treated at the Beijing Children's Hospital from January 2006 to December 2018. Th...

journal_title：Endocrine

authors： Xu ZD,Hui PP,Zhang W,Zeng Q,Zhang L,Liu M,Yan J,Wu YJ,Sang YM

更新日期：2021-01-27 00:00:00

abstract：:Regulation of energy homeostasis is tightly controlled by the central nervous system (CNS). Several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, ...

journal_title：Endocrine

authors： Seoane-Collazo P,Fernø J,Gonzalez F,Diéguez C,Leis R,Nogueiras R,López M

更新日期：2015-11-01 00:00:00

abstract：:Steroid hormones regulate levels of gonadotropin mRNA in the pituitary, and gonadotropic hormones in plasma. To determine whether estrogen receptor alpha (ERalpha) mediates steroid negative feedback, wild type (WT) and estrogen receptor alpha knockout (ERalphaKO) mice of both sexes were gonadectomized and implanted wi...

journal_title：Endocrine

authors： Wersinger SR,Haisenleder DJ,Lubahn DB,Rissman EF

更新日期：1999-10-01 00:00:00

abstract：:Thyroid hormones are now recognized to change in different disease states with important consequences on severity and prognosis of disease. However, little is known about thyroid hormones' alterations in acute liver failure (ALF). To study the changes in thyroid hormones and cardiac thyroid receptors during ALF, we su...

journal_title：Endocrine

authors： Kostopanagiotou G,Kalimeris K,Mourouzis I,Kostopanagiotou K,Arkadopoulos N,Panagopoulos D,Papoutsidakis N,Chranioti A,Pafiti A,Spanou D,Smyrniotis V,Pantos C

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Primary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs. MATERIAL AND METHODS:Serum anti-pituitary and anti-hypothalamus antibodies ...

journal_title：Endocrine

authors： Chiloiro S,Giampietro A,Angelini F,Arena V,Stigliano E,Tartaglione T,Mattogno PP,D'Alessandris QG,Lauretti L,Pontecorvi A,De Marinis L,Bianchi A

更新日期：2021-01-23 00:00:00

abstract：PURPOSE:11β-hydroxylase deficiency accounts for 5% of congenital adrenal hyperplasia cases. Diagnosis suspiction is classically based on the association between abnormal virilization, precocious puberty, and hypertension in 46XX or 46XY subjects. We investigated two families with siblings presenting with opposed clinic...

journal_title：Endocrine

authors： Valadares LP,Pfeilsticker ACV,de Brito Sousa SM,Cardoso SC,de Moraes OL,Gonçalves de Castro LC,de Oliveira RS,Lofrano-Porto A

更新日期：2018-11-01 00:00:00