Regulation of leptin expression and secretion by corticosteroids and insulin. Implications for body weight.

abstract：PURPOSE:In the general population, sleep disorders are associated with an increased risk of cognitive impairment. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have additional risk of cognitive impairment due to acromegaly treatmen...

journal_title：Endocrine

authors： Wennberg A,Lorusso R,Dassie F,Benavides-Varela S,Parolin M,De Carlo E,Fallo F,Mioni R,Vettor R,Semenza C,Maffei P

更新日期：2019-12-01 00:00:00

abstract：:Factors affecting longevity are complex and poorly understood. We have recently found that Ames dwarf mice (df/df), which are deficient in growth hormone (GH), prolactin, and thyroid-stimulating hormone, live significantly longer than their normal siblings whereas transgenic mice that overexpress GH exhibit reduced li...

journal_title：Endocrine

authors： Brown-Borg HM,Bode AM,Bartke A

更新日期：1999-08-01 00:00:00

abstract：:Many new techniques are rapidly being developed and applied to the study of normal and neoplastic pituitary. DNA microarrays are a uniquely efficient method for simultaneously assessing the expression levels of thousands of genes, identifying disease subphenotypes, and predicting disease progression. This article revi...

journal_title：Endocrine

authors： Qian X,Scheithauer BW,Kovacs K,Lloyd RV

更新日期：2005-10-01 00:00:00

abstract：:Studies on the effect of exogenous subclinical thyrotoxicosis on bone mineral density (BMD) in male patients treated with suppressive doses of levothyroxine for differentiated thyroid carcinoma (DTC) are not conclusive. In order to evaluate BMD (in femoral neck, lumbar spine, and distal radius) and bone fractures in m...

journal_title：Endocrine

authors： Reverter JL,Colomé E,Holgado S,Aguilera E,Soldevila B,Mateo L,Sanmartí A

更新日期：2010-06-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...

journal_title：Endocrine

authors： Friedmann S,Dantes A,Amsterdam A

更新日期：2005-04-01 00:00:00

abstract：:The original neuroprotective hypothesis of estrogen was based on the gender difference in brain response to the ischemia-reperfusion injury. Additional clinical reports also suggest that estrogen may improve cognition in patients with Alzheimer disease. 17beta-Estradiol is the most potent endogenous ligand of estrogen...

journal_title：Endocrine

authors： Chiueh C,Lee S,Andoh T,Murphy D

更新日期：2003-06-01 00:00:00

abstract：:Giant prolactinomas are rare tumors characterized by their large size, compressive symptoms, and extremely high prolactin secretion. The aim of this study is to describe our experience with a series of 16 giant prolactinomas cases in terms of clinical presentation, therapeutic decisions, and final outcomes. Retrospect...

journal_title：Endocrine

authors： Andujar-Plata P,Villar-Taibo R,Ballesteros-Pomar MD,Vidal-Casariego A,Pérez-Corral B,Cabezas-Agrícola JM,Álvarez-Vázquez P,Serramito R,Bernabeu I

更新日期：2017-01-01 00:00:00

abstract：:Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from indi...

journal_title：Endocrine

authors： Frisard M,Ravussin E

更新日期：2006-02-01 00:00:00

abstract：:Recent animal studies support close associations of Periostin with hepatosteatosis and steatohepatitis. This study is to evaluate the role of serum periostin in non-alcoholic fatty liver disease (NAFLD). A hospital-based age-/sex-matched case-control study was conducted. Binary logistic regression and receiver operati...

journal_title：Endocrine

authors： Zhu JZ,Zhu HT,Dai YN,Li CX,Fang ZY,Zhao DJ,Wan XY,Wang YM,Wang F,Yu CH,Li YM

更新日期：2016-01-01 00:00:00

abstract：:The relationship among plasma levels of immunoreactive (ir)-inhibin, inhibin A, inhibin pro-alphaC, FSH, estradiol-17beta and follicular growth were investigated during the normal estrous cycle in mares. Seven mares were used for two successive normal estrous cycles. Follicular diameters and ovulation were obtained by...

journal_title：Endocrine

authors： Medan MS,Nambo Y,Nagamine N,Shinbo H,Watanabe G,Groome N,Taya K

更新日期：2004-10-01 00:00:00

abstract：:Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic cell-line, a model for endochondral ossification, were analyzed. For this purpose, real-time PCR, Western blot...

journal_title：Endocrine

authors： Ben-Eliezer M,Phillip M,Gat-Yablonski G

更新日期：2007-10-01 00:00:00

abstract：:Administration of RU486 to late pregnant rats results in preterm delivery 24 h after treatment and the induction of a luteolytic process after labor. We investigated whether functional changes occurring within the corpora lutea after RU486 treatment were associated with morphologic features of apoptotic cell death. Ra...

journal_title：Endocrine

authors： Telleria CM,Goyeneche AA,Cavicchia JC,Stati AO,Deis RP

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabo...

journal_title：Endocrine

authors： Lindsey RC,Mohan S

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years. METHODS:A total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in ...

journal_title：Endocrine

authors： Hui Y,Wang J,An Y,Gong Q,Li H,Zhang B,Shuai Y,Chen Y,Hu Y,Li G

更新日期：2019-07-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...

journal_title：Endocrine

authors： Alkhateeb A,Marzouka NA,Tashtoush R

更新日期：2013-12-01 00:00:00

abstract：:We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...

journal_title：Endocrine

authors： Kulkarni-Paranjape T,Shah GV

更新日期：2007-06-01 00:00:00

abstract：:We re-assess the fasting plasma glucose (FPG) and 2-h post-load glucose (2HPG) in the diagnosis of both prediabetes and type 2 diabetes mellitus by developing a gold standard based on beta-cell function. The gold standard was developed in a cohort of 2,152 adult subjects without severe renal or liver dysfunction that ...

journal_title：Endocrine

authors： Doi SA,Ward GM

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the genotype has been observed. Mutation-negative patients with MEN1-associated tumors represent phenocopies. By comparing mutation-positive and mut...

journal_title：Endocrine

authors： Kövesdi A,Tóth M,Butz H,Szücs N,Sármán B,Pusztai P,Tőke J,Reismann P,Fáklya M,Tóth G,Somogyi A,Borka K,Erdei A,Nagy EV,Deák V,Valkusz Z,Igaz P,Patócs A,Grolmusz VK

更新日期：2019-08-01 00:00:00

abstract：:Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be associated with altered glucocorticoids sensitivity and changes in body composition and metabolic parameters. This study explored the relationship between single nucleotide polymorphisms (SNPs) of the NR3C1 gene and metabolic syndrome (...

journal_title：Endocrine

authors： Yan YX,Dong J,Zhang J,Liu F,Wang W,Zhang L,He Y

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:This study investigated trends in chronic glucocorticoid (GC) use in South Korea, and determined the association between chronic GC use and 5-year all-cause mortality. METHODS:A sample cohort was extracted from the South Korean National Health Insurance database. Patients prescribed a continuous dose of GC for...

journal_title：Endocrine

authors： Oh TK,Song IA

更新日期：2020-09-01 00:00:00

abstract：:Progesterone (P(4)) and estradiol (E(2)) regulate many cell functions through their interaction with specific intracellular receptors, which require the participation of coactivators such as SRC-1 and SRC-3 for enhancing their transcriptional activity. Coactivator expression is altered in many cancers and in some of t...

journal_title：Endocrine

authors： Hernández-Hernández OT,Rodríguez-Dorantes M,González-Arenas A,Camacho-Arroyo I

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovar...

journal_title：Endocrine

authors： Tedesco S,Adorni MP,Ronda N,Cappellari R,Mioni R,Barbot M,Pinelli S,Plebani M,Bolego C,Scaroni C,Bernini F,Fadini GP,Cignarella A

更新日期：2019-11-01 00:00:00

abstract：:Total bilirubin, not direct or indirect bilirubin, has been reported to associate inversely with metabolic syndrome. Therefore, we aimed to evaluate the association between bilirubin subtypes and metabolic syndrome among the Korean population. This study included 5,231 Koreans (3,008 men, 2,223 women) aged 30-87 years...

journal_title：Endocrine

authors： Jo J,Yun JE,Lee H,Kimm H,Jee SH

更新日期：2011-04-01 00:00:00

abstract：:The oncogenic activation of the rearranged during transfection (RET) proto-oncogene has a main role in the pathogenesis of medullary thyroid cancer (MTC). Several lines of evidence suggest that RET function could be influenced by cyclic AMP (cAMP)-dependent protein kinase A (PKA) activity. We evaluated the in vitro an...

journal_title：Endocrine

authors： Dicitore A,Grassi ES,Caraglia M,Borghi MO,Gaudenzi G,Hofland LJ,Persani L,Vitale G

更新日期：2016-01-01 00:00:00

abstract：:Numerous reports of rapid steroid hormone effects in diverse cell types cannot be explained by the generally prevailing theory that centers on the activity of hormone receptors located exclusively in the nucleus. Cell membrane forms of steroid hormone receptors coupled to intracellular signaling pathways may also play...

journal_title：Endocrine

authors： Pietras RJ,Nemere I,Szego CM

更新日期：2001-04-01 00:00:00

abstract：:Aging is associated with a significant decline in secretion of growth hormone. This in turn leads to reduced circulating IGF-I and changes in IGF-binding proteins. Growth hormone replacement to growth hormone-deficient individuals has been shown to improve quality of life, enhance bone and muscle mass, and reduce card...

journal_title：Endocrine

authors： Rosen CJ

更新日期：2000-04-01 00:00:00

abstract：:SHARPIN is a novel protein thought to interact with SHANK family and is widely expressed in multiple tissues/cells, including osteoblasts and osteoclasts. Loss-of-function of Sharpin develops the chronic proliferative dermatitis mutation (CPDM) in mice as well as a severe inflammation in other organs. The actual funct...

journal_title：Endocrine

authors： Xia T,Liang Y,Ma J,Li M,Gong M,Yu X

更新日期：2011-04-01 00:00:00

abstract：:Growth hormone-releasing hormone (GHRH) and somatostatin are the most important hypothalamic neurohormones controlling growth hormone (GH) secretion. Several neurotransmitters and neuropeptides also play an important role in the control of GH secretion, mainly acting via modulation of GHRH and somatostatin. In the pas...

journal_title：Endocrine

authors： Arvat E,Gianotti L,Giordano R,Broglio F,Maccario M,Lanfranco F,Muccioli G,Papotti M,Graziani A,Ghigo E,Deghenghi R

更新日期：2001-02-01 00:00:00

abstract：:Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...

journal_title：Endocrine

authors： Aslan M,Cosar N,Celik H,Aksoy N,Dulger AC,Begenik H,Soyoral YU,Kucukoglu ME,Selek S

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which are under-recognized, adding to morbidity and ...

journal_title：Endocrine

authors： Das L,Rai A,Mavuduru R,Vaiphei K,Sharma A,Gupta V,Bhadada SK,Lodha S,Panda N,Bhansali A,Singh P,Dutta P

更新日期：2020-08-01 00:00:00