Loss-of-function of SHARPIN causes an osteopenic phenotype in mice.

abstract：:The treatment of acromegaly is based on surgery, drugs, and radiotherapy as a third-line option. Fractionated stereotactic radiotherapy (FSRT) is a new technique with a need for long-term evaluation. The purpose of the study was to evaluate long-term results of FSRT in acromegaly. Overall, 34 patients [sex ratio 1.12,...

journal_title：Endocrine

authors： Diallo AM,Colin P,Litre CF,Diallo MM,Decoudier B,Bertoin F,Higel B,Patey M,Rousseaux P,Delemer B

更新日期：2015-12-01 00:00:00

abstract：:Many aspects of tuberoinfundibular dopaminergic neuronal function are increased by elevated prolactin (PRL) levels, including the activity of tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of dopamine. This study evaluated the roles of calmodulin, cyclic nucleotide-dependent protein kinase, and cal...

journal_title：Endocrine

authors： Arbogast LA

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...

journal_title：Endocrine

authors： Xie T,Ding H,Xia M,Zhang X,Sun W,Liu T,Gu Y,Sun C,Hu F

更新日期：2018-12-01 00:00:00

abstract：:The effect of stress on serum corticosteroid-binding globulin (CBG) was studied in adult male Sprague-Dawley rats. CBG was measured either by a homologous radioimmunoassay (RIA) or by a binding assay (BA) using 3H-corticosterone. Exposure of adult male rats to a severe stressor such as immobilization (IMO) for 1 h did...

journal_title：Endocrine

authors： Martí O,Martín M,Gavaldà A,Giralt M,Hidalgo J,Hsu BR,Kuhn RW,Armario A

更新日期：1997-04-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease, characterized by cutaneous and multi-organ fibrosis, and vascular abnormalities. Skin thickening is a characteristic feature of SSc and resembles myxedematous skin. Our aim was to correlate the degree of skin involvement in SSc patients with serum TSH levels, si...

journal_title：Endocrine

authors： Bagnato GL,Roberts WN,Fiorenza A,Arcuri C,Certo R,Trimarchi F,Ruggeri RM,Bagnato GF

更新日期：2016-02-01 00:00:00

abstract：:Chronic ethanol exposure causes alterations in biologic membranes of different cell types. (Na + K) adenosine triphosphatase (ATPase), a membrane-bound enzyme inhibited by the acute presence of ethanol, increases its activity in rat kidney after chronic ethanol consumption. The aim of this investigation was to evaluat...

journal_title：Endocrine

authors： Rodrigo R,Rivera G,Lucero Y,Larraguibel C

更新日期：2002-12-01 00:00:00

abstract：:The bovine corpus luteum contains a myristoylated alanine-rich C kinase substrate (MARCKS) protein known to crosslink actin filaments in the cytoskeletal cortex associated with the plasma membrane. We conducted experiments to determine whether concentrations of MARCKS mRNA and protein in the bovine corpus luteum varie...

journal_title：Endocrine

authors： Filley S,Supancic S,Salli U,Orwig K,Stormshak F

更新日期：2000-06-01 00:00:00

abstract：:The original neuroprotective hypothesis of estrogen was based on the gender difference in brain response to the ischemia-reperfusion injury. Additional clinical reports also suggest that estrogen may improve cognition in patients with Alzheimer disease. 17beta-Estradiol is the most potent endogenous ligand of estrogen...

journal_title：Endocrine

authors： Chiueh C,Lee S,Andoh T,Murphy D

更新日期：2003-06-01 00:00:00

abstract：:Adrenocorticotropin-secreting pituitary tumor represents about 10 % of pituitary adenomas and at the time of diagnosis most of them are microadenomas. Transsphenoidal surgery is the first-line treatment of Cushing's disease and accurate localization of the tumor within the gland is essential for selectively removing t...

journal_title：Endocrine

authors： Vitale G,Tortora F,Baldelli R,Cocchiara F,Paragliola RM,Sbardella E,Simeoli C,Caranci F,Pivonello R,Colao A,A.B.C. Group.

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To systematically evaluate the quality, consistency and the evidence support of guidelines for perioperative diabetes management. METHODS:We retrieved guidelines through systematic search, critically evaluated their quality and compared the recommendations of included guidelines. Five aspects were compared: ta...

journal_title：Endocrine

authors： Song X,Wang J,Gao Y,Yu Y,Zhang J,Wang Q,Ma X,Estille J,Jin X,Chen Y,Mu Y

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To assess the predictive value of some clinical and biochemical parameters, and of the +49 A/G polymorphism of the CTLA-4 gene, for long-term remission following the withdrawal of antithyroid drugs before starting antithyroid drug therapy. STUDY DESIGN:Observational, prospective and longitudinal study. METH...

journal_title：Endocrine

authors： García-Mayor RV,Álvarez-Vázquez P,Fluiters E,Valverde D,Andrade A

更新日期：2019-02-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinica...

journal_title：Endocrine

authors： Kurtulmus N,Mert M,Tanakol R,Yarman S

更新日期：2015-04-01 00:00:00

abstract：:Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...

journal_title：Endocrine

authors： Ryan DH

更新日期：2000-10-01 00:00:00

abstract：:Regulation of energy homeostasis is tightly controlled by the central nervous system (CNS). Several key areas such as the hypothalamus and brainstem receive and integrate signals conveying energy status from the periphery, such as leptin, thyroid hormones, and insulin, ultimately leading to modulation of food intake, ...

journal_title：Endocrine

authors： Seoane-Collazo P,Fernø J,Gonzalez F,Diéguez C,Leis R,Nogueiras R,López M

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years. METHODS:A total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in ...

journal_title：Endocrine

authors： Hui Y,Wang J,An Y,Gong Q,Li H,Zhang B,Shuai Y,Chen Y,Hu Y,Li G

更新日期：2019-07-01 00:00:00

abstract：:Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...

journal_title：Endocrine

authors： Yang P,Medan MS,Arai KY,Jin W,Watanabe G,Taya K

更新日期：2005-11-01 00:00:00

abstract：:Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comp...

journal_title：Endocrine

authors： Lee KA,Lee NY,Park TS,Jin HY

更新日期：2018-07-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...

journal_title：Endocrine

authors： Friedmann S,Dantes A,Amsterdam A

更新日期：2005-04-01 00:00:00

abstract：:There have been few reports on the development of metabolic disorders, especially when they are considered as a cluster. The purpose of this study was to describe risk profiles for metabolic syndrome (MetS) in elderly dwellers in Beijing, and to find their transition patterns over time. Data were derived from Beijing ...

journal_title：Endocrine

authors： Tao LX,Wang W,Zhu HP,Huo D,Zhou T,Pan L,Gao Q,Luo YX,Wu LJ,Li X,Tang Z,Guo XH

更新日期：2014-09-01 00:00:00

abstract：:In the human and non-human primate the major secretory product of the uterine glandular epithelial cells is glycodelin. The expression of glycodelin is associated with elevated progesterone levels as its production peaks during the late luteal phase of the menstrual cycle and in early pregnancy. Consistent with our pr...

journal_title：Endocrine

authors： Jaffe RC,Ferguson-Gottschall SD,Fazleabas AT

更新日期：2006-02-01 00:00:00

abstract：:The effects of endomorphin-1 (EM1) on behavioral responses and on the hypothalamic-pituitary-adrenal system were investigated in mice. Locomotor activity was measured in an "open-field" apparatus, with parallel recording of the numbers of rearings and groomings. Different doses of the peptide (250 ng to 5 microg) were...

journal_title：Endocrine

authors： Bujdosó E,Jászberényi M,Tömböly C,Tóth G,Telegdy G

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:11β-hydroxylase deficiency accounts for 5% of congenital adrenal hyperplasia cases. Diagnosis suspiction is classically based on the association between abnormal virilization, precocious puberty, and hypertension in 46XX or 46XY subjects. We investigated two families with siblings presenting with opposed clinic...

journal_title：Endocrine

authors： Valadares LP,Pfeilsticker ACV,de Brito Sousa SM,Cardoso SC,de Moraes OL,Gonçalves de Castro LC,de Oliveira RS,Lofrano-Porto A

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The evaluation of skeletal fragility in Cushing's syndrome (CS) is a clinical challenge, since dual-energy X-ray absorptiometry (DXA) does not capture abnormalities in bone microstructure induced by glucocorticoid excess. Hypercortisolism was shown to increase bone marrow adiposity, but it is still unknown whet...

journal_title：Endocrine

authors： Ferraù F,Giovinazzo S,Messina E,Tessitore A,Vinci S,Mazziotti G,Lania A,Granata F,Cannavò S

更新日期：2020-01-01 00:00:00

abstract：:Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775)...

journal_title：Endocrine

authors： Pawlak-Adamska E,Frydecka I,Bolanowski M,Tomkiewicz A,Jonkisz A,Karabon L,Partyka A,Nowak O,Szalinski M,Daroszewski J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIM:A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in overweight subjects is still a matter of concern. We studied free cortisol (urinary free cortiso...

journal_title：Endocrine

authors： Ceccato F,Lizzul L,Barbot M,Scaroni C

更新日期：2020-08-01 00:00:00

abstract：:Glucocorticoid hormones potentiate the toxic effects of neuronal stressors. Alteration of gene expression by glucocorticoids could contribute to neuronal susceptibility by downregulating the synthesis of proteins necessary to adapt to challenge. Using heat shock of hippocampal slices as a model for cellular insult, pr...

journal_title：Endocrine

authors： Barr CS,Dokas LA

更新日期：1998-04-01 00:00:00

abstract：:Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of...

journal_title：Endocrine

authors： Raff H,Bruder ED

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To evaluate whether losartan is able to induce beige adipocytes formation, focusing on the thermogenic gene expression and adipocyte remodeling in the subcutaneous white adipose tissue of diet-induced obese mice. METHODS:Male C57BL/6 mice received a control diet (10% energy as lipids) or a high-fat diet (50% e...

journal_title：Endocrine

authors： Graus-Nunes F,Rachid TL,de Oliveira Santos F,Barbosa-da-Silva S,Souza-Mello V

更新日期：2017-03-01 00:00:00

abstract：:Graves' disease (GD) and Hashimoto's thyroiditis (HT) are both common autoimmune diseases of the thyroid gland (AITD). The IL-4 is involved in both humoral and cellular immunity. The aim of this study was to test whether the IL-4 gene could be used as a genetic marker to predict the development of AITD amongst the Chi...

journal_title：Endocrine

authors： Chen RH,Chang CT,Wang TY,Chen CC,Tsai CH,Tsai FJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Patients with cortisol secreting adrenal adenomas present with Cushing's syndrome (CS), while 5-15% of subjects with adrenal incidentalomas have subclinical hypercortisolism (SH) as they have biochemical abnormalities suggesting autonomous cortisol secretion without associated clinical features of CS. GOALS...

journal_title：Endocrine

authors： Khawandanah D,ElAsmar N,Arafah BM

更新日期：2019-01-01 00:00:00