Abstract:
PURPOSE:To evaluate whether losartan is able to induce beige adipocytes formation, focusing on the thermogenic gene expression and adipocyte remodeling in the subcutaneous white adipose tissue of diet-induced obese mice. METHODS:Male C57BL/6 mice received a control diet (10% energy as lipids) or a high-fat diet (50% energy as lipids) for 10 weeks, followed by a 5-week treatment with losartan: control group, control-losartan group (10 mg/Kg/day), high-fat group and high-fat-losartan group (10 mg/Kg/day). Biochemical, morphometrical, stereological and molecular approaches were used to evaluate the outcomes. RESULTS:The high-fat diet elicited overweight, insulin resistance and adipocyte hypertrophy in the high-fat group, all of which losartan rescued in the high-fat-losartan group. These effects comply with the induction of beige adipocytes within the inguinal fat pads in high-fat-losartan group as they exhibited the greatest energy expenditure among the groups along with the presence uncoupling protein 1 positive multilocular adipocytes with enhanced peroxisome proliferator-activated receptor gamma coactivator 1-alpha and PR domain containing 16 mRNA levels, indicating a significant potential for mitochondrial biogenesis and adaptive thermogenesis. CONCLUSIONS:Our results show compelling evidence that losartan countered diet-induced obesity in mice by enhancing energy expenditure through beige adipocytes induction. Reduced body mass, increased insulin sensitivity, decreased adipocyte size and marked expression of uncoupling protein 1 by ectopic multilocular adipocytes support these findings. The use of losartan as a coadjutant medicine to tackle obesity and its related disorders merits further investigation.
journal_name
Endocrinejournal_title
Endocrineauthors
Graus-Nunes F,Rachid TL,de Oliveira Santos F,Barbosa-da-Silva S,Souza-Mello Vdoi
10.1007/s12020-016-1213-1subject
Has Abstractpub_date
2017-03-01 00:00:00pages
786-798issue
3eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-016-1213-1journal_volume
55pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency predisposes affected individuals highly susceptible to oxidative stress, which is one of the risk factors for diabetes. To evaluate the relationship between blood level of G6PD activity and diabetes in Taiwan, blood G6PD activity was analyzed among 237 patients with ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:19:2:191
更新日期:2002-11-01 00:00:00
abstract::AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 ge...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9736-6
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Analyze the role of somatostatin analogues (SSAs) in the treatment of sporadic and MEN1-related gastrinomas, trying to define whether recent trials have changed the landscape of gastrinoma therapy. METHODS:We evaluate the rationale of SSA use in the treatment of gastrinomas, summarize the current literature co...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-017-1420-4
更新日期:2018-04-01 00:00:00
abstract::The role of membrane-associated tubulin in TRH receptor-G protein coupling was investigated with the use of compounds that influence tubulin function. TRH-stimulated G protein GTPase activity in GH(3) cell membranes was used to determine receptor-G protein coupling. TRH-stimulated GTPase activity was abolished by G(qα...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02738873
更新日期:1996-02-01 00:00:00
abstract:PURPOSE:Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1307-4
更新日期:2017-07-01 00:00:00
abstract::We validated the effect of prolactin-releasing peptide (PrRP) on prolactin (PRL) secretion from rat anterior pituitary cells in in vitro culture. We found that culture conditions considerably influenced the response of the anterior pituitary cells to PrRP. Longer culture term (4 d) was required to obtain better respon...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:12:3:215
更新日期:2000-06-01 00:00:00
abstract::Diabetes mellitus is a major risk factor for cardiovascular disease. However, the excess risk of death may vary substantially in subgroups of patients with type 2 diabetes, being highest in those younger than 55 years of age. A HbA1c value of 7.0 % or less is recommended for most patients with type 2 diabetes to reduc...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-0981-y
更新日期:2016-10-01 00:00:00
abstract:UNLABELLED:Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. OBJECTIVE:To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. SUBJECTS:Seventeen healthy overweight and obese subjects...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9090-x
更新日期:2008-06-01 00:00:00
abstract::Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9842-5
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To perform an online survey about the use of Thyroid Imaging Reporting and Data System (TIRADS) classification in Italy. METHODS:An online questionnaire was administered to all members of the Italian Society of Medical and Interventional Radiology (Società Italiana di Radiologia Medica ed Interventistica, SIRM...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02199-3
更新日期:2020-05-01 00:00:00
abstract:PURPOSES:Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm. METHODS:In this retrospective case-control study, we enrolled 30 patient...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-02069-7
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited diso...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1368-4
更新日期:2017-09-01 00:00:00
abstract::In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:18:1:21
更新日期:2002-06-01 00:00:00
abstract::There are no data about the optimal supplementation therapy in HIV-infected patients with vitamin D (25OHD) deficiency. The aim of this study was to assess the effect of an oral monthly dose of 16,000 IU calcidiol. We performed a longitudinal cohort study of 365 HIV-infected patients (24 % females) was with sequential...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0489-2
更新日期:2015-06-01 00:00:00
abstract::Previous evidence supports the view that insulin, as well as insulin like growth factor-1 (IGF-1) provides neurotropic support for neurons in the central nervous system (CNS) and peripheral nervous system (PNS). In the present study we evaluated the effects of the intravenous infusion of IGF-1 on both necrosis and apo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0012-0
更新日期:2007-02-01 00:00:00
abstract::The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02994449
更新日期:1995-03-01 00:00:00
abstract::Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-013-9892-3
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Serum intact parathyroid hormone (iPTH) level is an early marker of post-thyroidectomy hypocalcemia. However, lack of methodological standardization to define timing and cut-off points of iPTH measurement limit its clinical applicability. Here, we evaluated the relationship between two distinct postoperative ti...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-018-1601-9
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influe...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-020-02536-6
更新日期:2021-01-01 00:00:00
abstract::Glucocorticoid hormones potentiate the toxic effects of neuronal stressors. Alteration of gene expression by glucocorticoids could contribute to neuronal susceptibility by downregulating the synthesis of proteins necessary to adapt to challenge. Using heat shock of hippocampal slices as a model for cellular insult, pr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:2:135
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:The study aimed to disclose mortality pattern and quantitatively evaluate risks for cause-specific mortality among thyroid cancer survivors. METHODS:We included 173,710 patients from the Surveillance, Epidemiology, and End Results (SEER) database with thyroid cancer diagnosed between 1975 and 2015. Standardize...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02445-8
更新日期:2020-08-08 00:00:00
abstract:OBJECTIVE:This study was to perform a meta-analysis to assess the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal glucose metabolism. METHODS:The data sources were PubMed and EMBASE up to June 2018. Studies providing the relationship between HTW phenotype and abnormal glucose metabolism we...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-019-01945-6
更新日期:2019-06-01 00:00:00
abstract::This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. The information available suggests that these amino acids exert a stimulatory action on hypophysial prolactin. Administration of a glutamate receptor ago...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:28:3:303
更新日期:2005-12-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced β-cell mass, partially due to an increased β-cell apoptosis rate. Pancreatic stone protein/regenerating protein (PSP/reg) is a secretory protein produced in the pancreas and up-regulated dramatically during pancreatic disease. Recent studies reveal...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0427-3
更新日期:2015-04-01 00:00:00
abstract::Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in T-lineage lymphocytes. Utilizing PRL-dependent Nb2-11 cultures, apoptosis-regulatory genes were evaluated for participation in dexamethasone- (DEX) provoked cell ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:9:2:163
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-007-0039-2
更新日期:2007-06-01 00:00:00
abstract::Several studies have demonstrated an imbalance between free radicals and the antioxidative system in individuals with thyroid dysfunction. However, oxidative stress has not been evaluated in patients with thyroidectomy and thyroparathyroidectomy, who are under replacement therapy. The objective of this study was to ev...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0270-6
更新日期:2015-02-01 00:00:00
abstract::Recent studies have reported that standardized uptake values of FDG-PET imaging might predict malignant thyroid nodules and can be used in the preoperative evaluation of thyroid lesions. The aim of our study was to evaluate FDG-PET imaging in patients with cold thyroid nodules and to compare the imaging findings with ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0580-3
更新日期:2015-09-01 00:00:00
abstract::Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-termina...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9141-3
更新日期:2009-06-01 00:00:00
abstract::Follicle-stimulating hormone is synthesized and secreted as a mixture of heterogeneous isoforms that differ from each other in carbohydrate structure, biological potency, and plasma half-life. The relative abundance of the FSH isoforms will depend on the endocrine status of the donor at the time of sample collection. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:23:2-3:189
更新日期:2004-03-01 00:00:00