Abstract:
UNLABELLED:Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. OBJECTIVE:To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. SUBJECTS:Seventeen healthy overweight and obese subjects of both sexes (24 - 48 years, BMI 34.6 +/- 1.1 kg/m2). METHODS:Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed. RESULTS:There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 +/- 0.87 to 6.75 +/- 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = -0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04). CONCLUSIONS:Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.
journal_name
Endocrinejournal_title
Endocrineauthors
Araya AV,Orellana X,Espinoza Jdoi
10.1007/s12020-008-9090-xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
300-4issue
3eissn
1355-008Xissn
1559-0100journal_volume
33pub_type
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