Analyses for susceptibility of rat anterior pituitary cells to prolactin-releasing peptide.


:We validated the effect of prolactin-releasing peptide (PrRP) on prolactin (PRL) secretion from rat anterior pituitary cells in in vitro culture. We found that culture conditions considerably influenced the response of the anterior pituitary cells to PrRP. Longer culture term (4 d) was required to obtain better responses of the anterior pituitary cells to PrRP in comparison to thyrotropin-releasing hormone (TRH). Under the culture conditions employed here, PrRP was comparable to TRH in the potency promoting PRL secretion, and the action of PrRP was very specific for PRL secretion. The susceptibility of the anterior pituitary cells to PrRP varied in female rats depending on the process of reproduction: the cells prepared from lactating rats were the most sensitive to PrRP compared with those from random-cycle and pregnant rats. Because the expression levels of PrRP receptor mRNA in the pituitary varied during the reproductive process, we speculated that the susceptibility of the anterior pituitary cells would reflect cellular changes including the expression level of PrRP receptors. In addition, treatment with estrogen in vivo enhanced the susceptibility of the cultured anterior pituitary cells in male rats. Our results indicate that the susceptibility of the rat anterior pituitary cells to PrRP is regulated by physiological mechanisms.






Kawamata Y,Fujii R,Fukusumi S,Habata Y,Hosoya M,Hinuma S,Kitada C,Onda H,Nishimura O,Fujino M




Has Abstract


2000-06-01 00:00:00














  • Optimal cutoffs for low skeletal muscle mass related to cardiovascular risk in adults: The Korea National Health and Nutrition Examination Survey 2009-2010.

    abstract::The possible association between low skeletal muscle mass and cardiovascular disease (CVD) risk factors necessitates estimation of muscle mass even in subjects with normal body mass index (BMI). This study was aimed to investigate optimal cutoffs for skeletal muscle mass reflecting CVD risk factors and to evaluate the...


    pub_type: 杂志文章


    authors: Kim Y,Han BD,Han K,Shin KE,Lee H,Kim TR,Cho KH,Kim DH,Kim YH,Kim H,Nam GE

    更新日期:2015-11-01 00:00:00

  • Low investigation rate for adrenal incidentalomas.

    abstract::The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should...


    pub_type: 信件


    authors: Bujawansa S,Bowen-Jones D

    更新日期:2011-08-01 00:00:00

  • Patients' knowledge about the outcomes of thyroid biopsy: a patient survey.

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    pub_type: 杂志文章


    authors: Singh Ospina N,Castaneda-Guarderas A,Ward R,Brito JP,Maraka S,Zeballos Palacios C,Yost KJ,Dean DS,Montori VM

    更新日期:2018-09-01 00:00:00

  • Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats.

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    pub_type: 杂志文章


    authors: You L,Sar M

    更新日期:1998-12-01 00:00:00

  • Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity.

    abstract::Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylp...


    pub_type: 杂志文章,评审


    authors: Ryan DH

    更新日期:2000-10-01 00:00:00

  • Spectral domain optical coherence tomography based imaging biomarkers for diabetic retinopathy.

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    pub_type: 杂志文章


    authors: Saxena S,Caprnda M,Ruia S,Prasad S,Ankita,Fedotova J,Kruzliak P,Krasnik V

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  • Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor.

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    pub_type: 杂志文章


    authors: Alfaidy N,Sun M,Challis JR,Gibb W

    更新日期:2003-04-01 00:00:00

  • Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans.

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    pub_type: 杂志文章,评审


    authors: Veldhuis JD,Iranmanesh A,Weltman A

    更新日期:1997-08-01 00:00:00

  • Bone turnover and mineral density in adult thalassemic patients: relationships with growth hormone secretory status and circulating somatomedins.

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    pub_type: 杂志文章


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    更新日期:2016-08-01 00:00:00

  • Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients.

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    pub_type: 杂志文章


    authors: Wang S,Sun H,Chen HY,Zhao ZF,Yang Y,Zhao YJ,Cui B,Ning G

    更新日期:2007-04-01 00:00:00

  • Kelp use in patients with thyroid cancer.

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    pub_type: 杂志文章


    authors: Rosen JE,Gardiner P,Saper RB,Pearce EN,Hammer K,Gupta-Lawrence RL,Lee SL

    更新日期:2014-05-01 00:00:00

  • Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women.

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    pub_type: 杂志文章


    authors: Lim JE,Jee SH

    更新日期:2015-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Ritchie PK,Knight HH,Ashby M,Judd AM

    更新日期:1996-12-01 00:00:00

  • Utility of the trabecular bone score (TBS) in secondary osteoporosis.

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    pub_type: 杂志文章,评审


    authors: Ulivieri FM,Silva BC,Sardanelli F,Hans D,Bilezikian JP,Caudarella R

    更新日期:2014-11-01 00:00:00

  • A synthetic peptide derived from mouse pituitary calcitonin cDNA sequence exhibits potent inhibition of prolactin secretion and prolactin mRNA abundance in primary mouse pituitary cells.

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    pub_type: 杂志文章


    authors: Kulkarni-Paranjape T,Shah GV

    更新日期:2007-06-01 00:00:00

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    pub_type: 杂志文章


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  • Growth hormone and aging.

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    pub_type: 杂志文章,评审


    authors: Rosen CJ

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    pub_type: 杂志文章,评审


    authors: Mikhail N

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  • Metabolic syndrome and the risk of cardiovascular complications in young patients with different phenotypes of polycystic ovary syndrome.

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    authors: Arbogast LA

    更新日期:2001-11-01 00:00:00

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    authors: Lazaros L,Pamporaki C,Vlahos N,Takenaka A,Kitsou C,Kosmas I,Sofikitis N,Stefos T,Zikopoulos K,Hatzi E,Georgiou I

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  • Medullary thyroid carcinoma treated with percutaneous ultrasound-guided radiofrequency ablation.

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    pub_type: 杂志文章,评审


    authors: Esposito K,Capuano A,Giugliano D

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  • Natural course of hypogonadism diagnosed during hospitalization in aged male patients.

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    authors: Iglesias P,Prado F,Muñoz A,Guerrero MT,Macías MC,Ridruejo E,Tajada P,García-Arévalo C,Díez JJ

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    pub_type: 杂志文章


    authors: Pérez-Armendariz EM,Nadal A,Fuentes E,Spray DC

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    authors: Sager S,Vatankulu B,Erdogan E,Mut S,Teksoz S,Ozturk T,Sonmezoglu K,Kanmaz B

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    pub_type: 杂志文章


    authors: Marques P,Barry S,Carlsen E,Collier D,Ronaldson A,Dorward N,Grieve J,Mendoza N,Nair R,Muquit S,Grossman AB,Korbonits M

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    pub_type: 杂志文章


    authors: Brown S,Georgatos M,Reifel C,Song JH,Shin SH,Hong M

    更新日期:2002-06-01 00:00:00