Pulmonary hypertension in thyroid diseases.

abstract：:Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...

journal_title：Endocrine

authors： Alkhateeb A,Marzouka NA,Tashtoush R

更新日期：2013-12-01 00:00:00

abstract：:Steroidogenic factor-1 (SF-1) is a transcription factor involved in regulation of steroidogenic enzymes. Recent evidence indicates that SF-1 is also important in the anterior pituitary gland, where it may influence gene expression in gonadotropes. We isolated a cDNA encoding ovine SF-1 and demonstrated that the SF-1 g...

journal_title：Endocrine

authors： Turzillo AM,Quirk CC,Juengel JL,Nett TM,Clay CM

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdomin...

journal_title：Endocrine

authors： Xie T,Ding H,Xia M,Zhang X,Sun W,Liu T,Gu Y,Sun C,Hu F

更新日期：2018-12-01 00:00:00

abstract：:Acromegaly is a debilitating disease usually caused by a growth-hormone secreting pituitary adenoma. Therapeutic goals include improvement of symptoms, reduction in tumor mass, biochemical normalization, and preservation of pituitary function. Treatment options include transsphenoidal surgery, radiation, and pharmacot...

journal_title：Endocrine

authors： Danoff A,Kleinberg D

更新日期：2003-04-01 00:00:00

abstract：:RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...

journal_title：Endocrine

authors： Zhang X,Healy C,Nothnick WB

更新日期：2012-08-01 00:00:00

abstract：:Steroid biosynthesis begins with the enzymatic conversion of cholesterol to pregnenolone. This reaction is catalyzed by the cytochrome P450 side-chain cleavage enzyme (P450scc), which is located on the matrix side of the inner mitochondrial membrane. Although the rate-limiting enzymatic step in steroidogenesis is the ...

journal_title：Endocrine

authors： Sandhoff TW,McLean MP

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:To perform an online survey about the use of Thyroid Imaging Reporting and Data System (TIRADS) classification in Italy. METHODS:An online questionnaire was administered to all members of the Italian Society of Medical and Interventional Radiology (Società Italiana di Radiologia Medica ed Interventistica, SIRM...

journal_title：Endocrine

authors： Mauri G,Gitto S,Cantisani V,Vallone G,Schiavone C,Papini E,Sconfienza LM

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited diso...

journal_title：Endocrine

authors： Razavi SA,Modarressi MH,Yaghmaei P,Tavangar SM,Hedayati M

更新日期：2017-09-01 00:00:00

abstract：:We have investigated the effects of different patterns of administration of recombinant human growth hormone (rhGH) on weight gain, organ growth, serum GH binding protein (GHBP) and insulin-like growth factor-l (IGF-1) levels in a series of studies using hypophysectomized (Hx) or GH-deficient dwarf (dw/dw) rats. Anima...

journal_title：Endocrine

authors： Clark RG,Mortensen D,Carlsson LM,Carmignac D,Robinson I

更新日期：1995-10-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...

journal_title：Endocrine

authors： Friedmann S,Dantes A,Amsterdam A

更新日期：2005-04-01 00:00:00

abstract：:To evaluate the role of central subfield thickness (CST), cube average thickness (CAT), and cube volume (CV) as imaging biomarkers for severity of diabetic retinopathy within the ETDRS-based grades of retinopathy using spectral domain optical coherence tomography (SD-OCT). This study aims to evaluate the role of macul...

journal_title：Endocrine

authors： Saxena S,Caprnda M,Ruia S,Prasad S,Ankita,Fedotova J,Kruzliak P,Krasnik V

更新日期：2019-12-01 00:00:00

abstract：:Succinic acid esters are currently under investigation as possible insulinotropic tools in the treatment of noninsulin-dependent diabetes mellitus. The present article introduces three novel nutrient esters and aims mainly to explore, in both normal and GK rats, the secretory response to such esters when tested alone ...

journal_title：Endocrine

authors： Sener A,Kadiata MM,Ladrière L,Malaisse WJ

更新日期：1997-10-01 00:00:00

abstract：:Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tom...

journal_title：Endocrine

authors： Ulivieri FM,Silva BC,Sardanelli F,Hans D,Bilezikian JP,Caudarella R

更新日期：2014-11-01 00:00:00

abstract：:Effects of hypothyroidism on the glucose and insulin levels are controversial, and its impact on the Langerhans islet morphology of adult subjects has been poorly addressed. In spite of hypothyroidism and diabetes mellitus are more frequent in females than in males, most studies using animal models have been done in m...

journal_title：Endocrine

authors： Rodríguez-Castelán J,Nicolás L,Morimoto S,Cuevas E

更新日期：2015-04-01 00:00:00

abstract：:Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...

journal_title：Endocrine

authors： Guaraldi F,Prencipe N,di Giacomo V,Scanarini M,Gasco V,Gardiman MP,Berton AM,Ghigo E,Grottoli S

更新日期：2013-08-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease, characterized by cutaneous and multi-organ fibrosis, and vascular abnormalities. Skin thickening is a characteristic feature of SSc and resembles myxedematous skin. Our aim was to correlate the degree of skin involvement in SSc patients with serum TSH levels, si...

journal_title：Endocrine

authors： Bagnato GL,Roberts WN,Fiorenza A,Arcuri C,Certo R,Trimarchi F,Ruggeri RM,Bagnato GF

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...

journal_title：Endocrine

authors： Yu X,Liu C,Yan M,Gong W,Wang Y

更新日期：2020-08-10 00:00:00

abstract：:Stimulation of dopamine D2 receptors inhibits melanotrope pro-opiomelanocortin (POMC) biosynthesis and alpha-melanocyte-stimulating hormone (MSH) secretion. These effects are mediated by G-protein alpha i- and alpha o-subunits and are reversed by stimulating receptors linked to activation of G alpha s protein. Melanot...

journal_title：Endocrine

authors： Sands SA,Dickerson DS,Morris SJ,Chronwall BM

更新日期：1997-06-01 00:00:00

abstract：:Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis and atherosclerosis. The testicular feminised mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet...

journal_title：Endocrine

authors： Kelly DM,Akhtar S,Sellers DJ,Muraleedharan V,Channer KS,Jones TH

更新日期：2016-11-01 00:00:00

abstract：:Recent animal studies support close associations of Periostin with hepatosteatosis and steatohepatitis. This study is to evaluate the role of serum periostin in non-alcoholic fatty liver disease (NAFLD). A hospital-based age-/sex-matched case-control study was conducted. Binary logistic regression and receiver operati...

journal_title：Endocrine

authors： Zhu JZ,Zhu HT,Dai YN,Li CX,Fang ZY,Zhao DJ,Wan XY,Wang YM,Wang F,Yu CH,Li YM

更新日期：2016-01-01 00:00:00

abstract：:Insulin pumps operate almost universally in the work environment. Tubeless insulin pumps are a relatively recent development for management of insulin-dependent diabetes. This is the first report of location-dependent failure of insulin pump function, possibly due to external interference, occurring only in the settin...

journal_title：Endocrine

authors： Reiher AE,Gallagher TA,Emanuele MA

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Low mineral mass and reduced bone strength with increased fracture risk are the main causes of morbidity in Thalassemia Major (TM). The pathogenesis is multifactorial and includes ineffective erythropoiesis with medullary expansion, multiple endocrine dysfunctions, direct iron bone deposition, deferoxamine-i...

journal_title：Endocrine

authors： Pellegrino F,Zatelli MC,Bondanelli M,Carnevale A,Cittanti C,Fortini M,Gamberini MR,Giganti M,Ambrosio MR

更新日期：2019-09-01 00:00:00

abstract：:The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical ...

journal_title：Endocrine

authors： Ilter A,Kırış A,Kaplan Ş,Kutlu M,Şahin M,Erem C,Civan N,Kangül F

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controll...

journal_title：Endocrine

authors： Pivonello R,Muscogiuri G,Holder G,Paul M,Sarp S,Lesogor A,Jordaan P,Eisinger J,Colao A

更新日期：2018-04-01 00:00:00

abstract：:Tumor suppressor p53 is a transcriptional factor that determines cell fate in response to multiple stressors, such as oxidative stress and endoplasmic reticulum stress, in the majority of cells. However, its role in pancreatic beta cells is not well documented. Our previous research has revealed that glycation-serum (...

journal_title：Endocrine

authors： Li Y,Zhang T,Huang Q,Sun Y,Chang X,Zhang H,Zhu Y,Han X

更新日期：2016-11-01 00:00:00

abstract：:To determine whether murine mammary growth is modulated by local insulin-like growth factor-1 (IGF-1) production, expression of recombinant IGF-1 was directed to the mammary glands of transgenic mice using an ovine prepro IGF-1 cDNA under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promote...

journal_title：Endocrine

authors： Weber MS,Boyle PL,Corl BA,Wong EA,Gwazdauskas FC,Akers RM

更新日期：1998-06-01 00:00:00

abstract：:The secreted hepatokine fetuin-A emerges as an independent predictor of type 2 diabetes in adulthood. The overall aims of this study were: (1) to investigate the associations of fetuin-A with adiposity and insulin resistance, as well as its relationship with adipokines, in prepubertal children, and, (2) to evaluate wh...

journal_title：Endocrine

authors： Murdolo G,Tortoioli C,Celi F,Bini V,Papi F,Brozzetti A,Falorni A

更新日期：2017-05-01 00:00:00

abstract：:Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...

journal_title：Endocrine

authors： Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2005-02-01 00:00:00

abstract：:Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor n...

journal_title：Endocrine

authors： Cetin C,Baş F,Uçar A,Poyrazoğlu S,Saka N,Bundak R,Darendeliler F

更新日期：2014-12-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common health problem, and associated with obesity, metabolic syndrome (MetS), and diabetes. Growing evidence shows that 25-hydroxyvitamin-D3 (25-OH-D) insufficiency and high parathyroid hormone (PTH) levels may be correlated to glucose intolerance, MetS, obesity, and cardi...

journal_title：Endocrine

authors： Erden ES,Genc S,Motor S,Ustun I,Ulutas KT,Bilgic HK,Oktar S,Sungur S,Erem C,Gokce C

更新日期：2014-03-01 00:00:00